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TLR3 and diabetes mellitus are reported together in 1 article.
Gene
TLR3
- HGNC
- HGNC:11849
43articles
43mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
COVID-19 3hepatitis B 3hepatitis C 3hepatocellular carcinoma 3HIV infection 2autism spectrum disorder 2neurodevelopmental disorder 2tuberculosis 2
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity.
PMID 36552771 | PMCID PMC9776802 | DOI 10.3390/cells11244007 · Cells · 2022 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR3 | “Furthermore, TLR3/TLR7/IRAK1 and TLR3/TLR9 were identified as independent predictors of AT SRA1 expression in individuals with obesity and T2D, respectively.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Steroid receptor RNA activator gene (SRA1) emerges as a player in pathophysiological responses of adipose tissue (AT) in metabolic disorders such as obesity and type 2 diabetes (T2D).” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | SRA1 | “Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity.” | 0.98 | hgnc_dict_v1 |
| gene | IRAK1 | “The gene expression of SRA1, TLRs-2,3,4,7,8,9,10 and their downstream signaling mediators including IRFs-3,4,5, myeloid differentiation factor 88 (MyD88), interleukin-1 receptor-associated kinase 1 (IRAK1), and nuclear factor-κB (NF-κB) were determined using qRT-PCR and SRA1 protein expression was determined by immunohistochemistry.” | 0.98 | hgnc_dict_v1 |