Type	Entity	Source evidence	Confidence	Extractor
gene	TLR4	“The collected samples were then analyzed for gene expression and protein levels of mTOR, STAT3, TGF-β, β-catenin, NFκB, TNF-α, TLR4, and NLRP3.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“Ligustilide Attenuates Neuroinflammation and Fibrosis in an Aluminum Chloride-induced Rat Model of Alzheimer's Disease via mTOR/STAT3 Signaling Inhibition.”	0.93	phenotype_alias_lexicon_v2
gene	STAT3	“Ligustilide Attenuates Neuroinflammation and Fibrosis in an Aluminum Chloride-induced Rat Model of Alzheimer's Disease via mTOR/STAT3 Signaling Inhibition.”	0.98	hgnc_dict_v1
gene	AKAP1	“Ligustilide has been reported to ameliorate AD by inhibiting PKA/AKAP1 or inducing α-secretase, but no prior research has examined its ability to activate the inflammasome in AD.”	0.98	hgnc_dict_v1

PMID 38218505 | DOI 10.1016/j.jep.2024.117731 · Journal of ethnopharmacology · 2024 · 6 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TLR4	“Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“One of the most prevalent neurodegenerative disorders is Alzheimer's disease (AD) in which neuroinflammation and oxidative stress are its main pathogenic processes.”	0.93	phenotype_alias_lexicon_v2
gene	LRP1	“Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues.”	0.98	hgnc_dict_v1
gene	NLRP3	“Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues.”	0.98	hgnc_dict_v1

PMID 39136502 | DOI 10.2174/0115672050333388240801043509 · Current Alzheimer research · 2024 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TLR4	“OBJECTIVES: We aimed to explore the potential therapeutic effects of Arctiin on rats with AD by evaluating the expression of TLR4, NLRP3, STAT3, TGF-β, cyclin D1, and CDK2.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“BACKGROUND: Alzheimer's disease (AD) affects approximately 50 million people globally and is expected to triple by 2050.”	0.93	phenotype_alias_lexicon_v2
gene	NLRP3	“OBJECTIVES: We aimed to explore the potential therapeutic effects of Arctiin on rats with AD by evaluating the expression of TLR4, NLRP3, STAT3, TGF-β, cyclin D1, and CDK2.”	0.98	hgnc_dict_v1
gene	STAT3	“OBJECTIVES: We aimed to explore the potential therapeutic effects of Arctiin on rats with AD by evaluating the expression of TLR4, NLRP3, STAT3, TGF-β, cyclin D1, and CDK2.”	0.98	hgnc_dict_v1

PMID 36656815 | PMCID PMC9851541 | DOI 10.1371/journal.pone.0279616 · PloS one · 2023 · 6 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TLR4	“When Aß binds to either CD36 or TLR4, it sets off a chain reaction of inflammatory chemokines and cytokines that ultimately results in neurodegeneration.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“Wheat ergot fungus-derived and modified drug for inhibition of intracranial aneurysm rupture due to dysfunction of TLR-4 receptor in Alzheimer's disease.”	0.93	phenotype_alias_lexicon_v2
gene	CD14	“There is a possibility that Aß oligomers and fibrils can be recognised by TLRs, in addition to the microglial receptors CD14, CD36, and CD47.”	0.98	hgnc_dict_v1
gene	CD36	“There is a possibility that Aß oligomers and fibrils can be recognised by TLRs, in addition to the microglial receptors CD14, CD36, and CD47.”	0.98	hgnc_dict_v1

PMID 35052591 | PMCID PMC8772758 | DOI 10.3390/antiox11010087 · Antioxidants (Basel, Switzerland) · 2021 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TLR4	“Allicin inhibits neuroinflammation by suppressing the ROS production, inhibition of TLR4/MyD88/NF-κB, P38 and JNK pathways.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“As an inhibitor of cholinesterase and (AChE) and butyrylcholinesterase (BuChE) it can be applied to manage the Alzheimer's disease, helps to maintain the balance of neurotransmitters in case of autism spectrum disorder (ASD) and attention deficit hyperactive syndrome (ADHD).”	0.93	phenotype_alias_lexicon_v2
phenotype	autism spectrum disorder	“As an inhibitor of cholinesterase and (AChE) and butyrylcholinesterase (BuChE) it can be applied to manage the Alzheimer's disease, helps to maintain the balance of neurotransmitters in case of autism spectrum disorder (ASD) and attention deficit hyperactive syndrome (ADHD).”	0.98	phenotype_alias_lexicon_v2
phenotype	intellectual disability	“Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment.”	0.93	phenotype_alias_lexicon_v2

PMID 31815123 | PMCID PMC6877979 | DOI 10.1155/2019/1767203 · BioMed research international · 2019 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TLR4	“Activation of toll-like receptor 4 (TLR4) through TLR4 agonist, lipopolysaccharide (LPS), stimulation initiate a signaling cascade whereby the TLR4-LPS interaction has been found to result in physiological and behavioural changes including retardation of motor activity in the mouse model.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“Neurological diseases particularly Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and epilepsy are on the rise all around the world causing morbidity and mortality globally with a common symptom of gradual loss or impairment of motor behaviour.”	0.93	phenotype_alias_lexicon_v2
phenotype	epilepsy	“Neurological diseases particularly Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and epilepsy are on the rise all around the world causing morbidity and mortality globally with a common symptom of gradual loss or impairment of motor behaviour.”	0.98	phenotype_alias_lexicon_v2
phenotype	stroke	“Neurological diseases particularly Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and epilepsy are on the rise all around the world causing morbidity and mortality globally with a common symptom of gradual loss or impairment of motor behaviour.”	0.98	phenotype_alias_lexicon_v2