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TLR4 and hepatitis B are reported together in 2 articles.
Gene
TLR4
- HGNC
- HGNC:11850
220articles
220mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
diabetes mellitus 12ulcerative colitis 12inflammatory bowel disease 10autism spectrum disorder 8Alzheimer disease 6epilepsy 6COVID-19 5SARS 5
Reported variants (articles · ClinVar status)
Phenotype
Hepatitis B
255articles
255mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Downregulation of Toll-Like Receptor Gene Expression Among Hepatitis B Virus-Positive Human Patients.
PMID 40970057 | PMCID PMC12442744 | DOI 10.7759/cureus.90391 · Cureus · 2025 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR4 | “TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, and TLR9 were significantly downregulated in both genotypes as compared to controls, with genotype D showing greater downregulation of TLR1, TLR5, TLR6, and TLR7 among HBV-positive patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis B | “Downregulation of Toll-Like Receptor Gene Expression Among Hepatitis B Virus-Positive Human Patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TLR9 | “Toll-like receptors (TLRs), notably TLR9, are critical for recognizing viral DNA and driving innate immune responses.” | 0.98 | hgnc_dict_v1 |
| gene | TLR1 | “TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, and TLR9 were significantly downregulated in both genotypes as compared to controls, with genotype D showing greater downregulation of TLR1, TLR5, TLR6, and TLR7 among HBV-positive patients.” | 0.98 | hgnc_dict_v1 |
Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection.
PMID 31485165 | PMCID PMC6717085 | DOI 10.1016/j.sjbs.2016.11.010 · Saudi journal of biological sciences · 2019 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR4 | “NOD2 is a member of the NOD-like receptor (NLR) family of pattern recognition receptors (PRRs), while MD-2 is a co-receptor for Toll-like receptor 4 (TLR4), which comprises another group of PRRs.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis B | “Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | NOD2 | “Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “HBV-infected patients were categorized into three groups based on the clinical stage of the infection: inactive HBV carriers, active HBV carriers, and patients with liver cirrhosis + hepatocellular carcinoma (HCC).” | 0.98 | phenotype_alias_lexicon_v2 |