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TLR4 and tuberculosis are reported together in 2 articles.
Gene
TLR4
- HGNC
- HGNC:11850
220articles
220mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
diabetes mellitus 12ulcerative colitis 12inflammatory bowel disease 10autism spectrum disorder 8Alzheimer disease 6epilepsy 6COVID-19 5SARS 5
Reported variants (articles · ClinVar status)
Phenotype
Tuberculosis
405articles
405mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60TZ1391: a computationally designed circular mRNA multi-epitope vaccine candidate against Mycobacterium tuberculosis via TLR3 immunomodulation.
PMID 41484553 | PMCID PMC12930736 | DOI 10.1186/s12865-025-00795-4 · BMC immunology · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR4 | “Molecular docking against TLR3, TLR4, and TLR8 identified two top-performing candidates.” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “TZ1391: a computationally designed circular mRNA multi-epitope vaccine candidate against Mycobacterium tuberculosis via TLR3 immunomodulation.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TLR3 | “TZ1391: a computationally designed circular mRNA multi-epitope vaccine candidate against Mycobacterium tuberculosis via TLR3 immunomodulation.” | 0.98 | hgnc_dict_v1 |
| gene | TLR8 | “Molecular docking against TLR3, TLR4, and TLR8 identified two top-performing candidates.” | 0.98 | hgnc_dict_v1 |
Toll Like Receptor-4 Gene Polymorphism and Susceptibility to Pulmonary Tuberculosis.
PMID 31926490 · The Egyptian journal of immunology · 2019 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR4 | “A trend toward increased frequency of TT and CT genotypes of TLR4 at (1196C/T) were also observed in PTB patients as compared to control group (48.3% vs.” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “Toll Like Receptor-4 Gene Polymorphism and Susceptibility to Pulmonary Tuberculosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “This study investigated whether variants in TLR-4 896A/G (Asp299Gly) and TLR-4 1196C/T (Thr399Ile) genes are related with susceptibility or resistance to pulmonary tuberculosis (PTB) in Saudi population. Genotyping of TLR-4 896A/G, TLR-4 1196C/T gene was performed by polymerase chain reaction followed by restriction fragment length polymorphism (PCR -RFLP) in 60 PTB patients and 60 control subjects. This study suggests that that TLR4 polymorphism especially TLR4 rs4986791 may be associated with increase susceptibility to pulmonary tuberculosis, and C allele of rs4986791 is a promising protective factor for tuberculosis susceptibility in Saudi population.” | 0.95 | saudi_context_rules_v1 |
| variant | rs4986791 | “This study suggests that that TLR4 polymorphism especially TLR4 rs4986791 may be associated with increase susceptibility to pulmonary tuberculosis, and C allele of rs4986791 is a promising protective factor for tuberculosis susceptibility in Saudi population.” | 0.90 | hgvs_regex_v1 |