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TM6SF2 and hepatitis C are reported together in 3 articles.
Gene
TM6SF2
- HGNC
- HGNC:11861
5articles
5mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
hepatitis C 3hepatitis B 2coronary artery disease 1diabetes mellitus 1hepatocellular carcinoma 1thalassemia 1
Reported variants (articles · ClinVar status)
Phenotype
Hepatitis C
421articles
421mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Inhibition of Cellular Factor TM6SF2 Suppresses Secretion Pathways of Hepatitis B, Hepatitis C, and Hepatitis D Viruses.
PMID 38408366 | DOI 10.1093/infdis/jiae098 · The Journal of infectious diseases · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TM6SF2 | “Inhibition of Cellular Factor TM6SF2 Suppresses Secretion Pathways of Hepatitis B, Hepatitis C, and Hepatitis D Viruses.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis C | “Inhibition of Cellular Factor TM6SF2 Suppresses Secretion Pathways of Hepatitis B, Hepatitis C, and Hepatitis D Viruses.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hepatitis B | “Inhibition of Cellular Factor TM6SF2 Suppresses Secretion Pathways of Hepatitis B, Hepatitis C, and Hepatitis D Viruses.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs58542926 | “Moreover, in a cohort of people with hepatitis B, a TM6SF2 polymorphism (rs58542926 CT/TT, which causes protein misfolding and reduced TM6SF2 in the liver) correlated with lower concentrations of subviral particles in blood, complementing our previous work showing decreased HCV viral load in people with this polymorphism.” | 0.90 | hgvs_regex_v1 |
PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study.
PMID 36028802 | PMCID PMC9414345 | DOI 10.1186/s12876-022-02469-6 · BMC gastroenterology · 2022 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TM6SF2 | “PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis C | “PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PNPLA3 | “PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study.” | 0.98 | hgnc_dict_v1 |
| variant | p.I148M | “BACKGROUND: The present study investigates if common missense functional variants p.I148M and p.E167K in PNPLA3 and TM6SF2 genes, respectively, associate with development of hepatic fibrosis and cirrhosis in a geographically novel cohort of Pakistani chronic hepatitis C (CHC) patients.” | 0.95 | hgvs_regex_v1 |
Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.
PMID 26822232 | DOI 10.1002/hep.28475 · Hepatology (Baltimore, Md.) · 2016 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TM6SF2 | “Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis C | “Serum inflammatory markers and hepatic expression of TM6SF2 and genes regulating lipid metabolism were assessed in a subset with chronic hepatitis C (CHC).” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hepatitis B | “The rs58542926 T allele was more prevalent in 502 NAFLD patients than controls (P = 0.02) but not different in cohorts with CHC (n = 2023) and chronic hepatitis B (n = 507).” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs58542926 | “Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.” | 0.90 | hgvs_regex_v1 |