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TMPRSS2 and MERS are reported together in 1 article.
Gene
TMPRSS2
- HGNC
- HGNC:11876
22articles
22mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
MERS
230articles
230mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective.
PMID 28855003 | PMCID PMC7079582 | DOI 10.1099/jmm.0.000565 · Journal of medical microbiology · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TMPRSS2 | “These include viral S protein targeting; inhibitors of host proteases, including TMPRSS2, cathepsin L and furin protease, and of viral M(pro) and the PL(pro) proteases; convalescent plasma; and vaccine candidates.” | 0.98 | hgnc_dict_v1 |
| phenotype | MERS | “A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | DPP4 | “The Medline database was searched using combinations and variations of terms, including 'Middle East respiratory syndrome coronavirus', 'MERS-CoV', 'SARS', 'therapy', 'molecular', 'vaccine', 'prophylactic', 'S protein', 'DPP4', 'heptad repeat', 'protease', 'inhibitor', 'anti-viral', 'broad-spectrum', 'interferon', 'convalescent plasma', 'lopinavir ritonavir', 'antibodies', 'antiviral peptides' and 'live attenuated viruses'.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “The current therapies have mainly been adapted from severe acute respiratory syndrome (SARS-CoV) treatments, including broad-spectrum antibiotics, corticosteroids, interferons, ribavirin, lopinavir-ritonavir or mycophenolate mofetil, and have not been subject to well-organized clinical trials.” | 0.93 | phenotype_alias_lexicon_v2 |