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TMPRSS2 and SARS are reported together in 4 articles.
Gene
TMPRSS2
- HGNC
- HGNC:11876
22articles
22mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
SARS
347articles
347mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Computational screening of camostat and related compounds against human TMPRSS2: A potential treatment of COVID-19.
PMID 35095307 | PMCID PMC8787670 | DOI 10.1016/j.jsps.2022.01.005 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TMPRSS2 | “Computational screening of camostat and related compounds against human TMPRSS2: A potential treatment of COVID-19.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “There is still a necessity for highly effective small molecular agents to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | COVID-19 | “Computational screening of camostat and related compounds against human TMPRSS2: A potential treatment of COVID-19.” | 0.98 | phenotype_alias_lexicon_v2 |
Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD.
PMID 32537478 | PMCID PMC7242205 | DOI 10.1016/j.omtm.2020.05.013 · Molecular therapy. Methods & clinical development · 2020 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TMPRSS2 | “Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “It has been reported that angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are the main cell entry proteins for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and play a critical role in causing coronavirus disease 2019 (COVID-19).” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | ACE2 | “Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “It has been reported that angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are the main cell entry proteins for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and play a critical role in causing coronavirus disease 2019 (COVID-19).” | 0.98 | phenotype_alias_lexicon_v2 |
Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies.
PMID 33137894 | PMCID PMC7663346 | DOI 10.3390/molecules25215007 · Molecules (Basel, Switzerland) · 2020 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TMPRSS2 | “SARS-CoV2 infection depends on the host cell Angiotensin-Converting Enzyme-2 (ACE2) and Transmembrane Serine Protease-2 (TMPRSS2), where the virus uses ACE2 for entry and TMPRSS2 for S protein priming.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), which caused novel corona virus disease-2019 (COVID-19) pandemic, necessitated a global demand for studies related to genes and enzymes of SARS-CoV2.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | ACE2 | “SARS-CoV2 infection depends on the host cell Angiotensin-Converting Enzyme-2 (ACE2) and Transmembrane Serine Protease-2 (TMPRSS2), where the virus uses ACE2 for entry and TMPRSS2 for S protein priming.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), which caused novel corona virus disease-2019 (COVID-19) pandemic, necessitated a global demand for studies related to genes and enzymes of SARS-CoV2.” | 0.98 | phenotype_alias_lexicon_v2 |
A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective.
PMID 28855003 | PMCID PMC7079582 | DOI 10.1099/jmm.0.000565 · Journal of medical microbiology · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TMPRSS2 | “These include viral S protein targeting; inhibitors of host proteases, including TMPRSS2, cathepsin L and furin protease, and of viral M(pro) and the PL(pro) proteases; convalescent plasma; and vaccine candidates.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “The current therapies have mainly been adapted from severe acute respiratory syndrome (SARS-CoV) treatments, including broad-spectrum antibiotics, corticosteroids, interferons, ribavirin, lopinavir-ritonavir or mycophenolate mofetil, and have not been subject to well-organized clinical trials.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | DPP4 | “The Medline database was searched using combinations and variations of terms, including 'Middle East respiratory syndrome coronavirus', 'MERS-CoV', 'SARS', 'therapy', 'molecular', 'vaccine', 'prophylactic', 'S protein', 'DPP4', 'heptad repeat', 'protease', 'inhibitor', 'anti-viral', 'broad-spectrum', 'interferon', 'convalescent plasma', 'lopinavir ritonavir', 'antibodies', 'antiviral peptides' and 'live attenuated viruses'.” | 0.98 | hgnc_dict_v1 |
| phenotype | MERS | “A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective.” | 0.93 | phenotype_alias_lexicon_v2 |