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TNFAIP3 and rheumatoid arthritis are reported together in 2 articles.
Gene
TNFAIP3
- HGNC
- HGNC:11896
6articles
6mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Rheumatoid arthritis
212articles
212mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60A CD40 variant is associated with systemic bone loss among patients with rheumatoid arthritis.
PMID 35107652 | DOI 10.1007/s10067-021-05998-9 · Clinical rheumatology · 2022 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TNFAIP3 | “METHODS: IRAK-1 rs3027898, IRAK-2 rs3844283, IRAK-2 rs708035, IFIH1 rs1990760, CD40 rs48104850, TNFAIP3 rs2230926, and miR146-a rs2910164 were genotyped in 176 adult RA patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “A CD40 variant is associated with systemic bone loss among patients with rheumatoid arthritis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD40 | “A CD40 variant is associated with systemic bone loss among patients with rheumatoid arthritis.” | 0.98 | hgnc_dict_v1 |
| gene | IFIH1 | “METHODS: IRAK-1 rs3027898, IRAK-2 rs3844283, IRAK-2 rs708035, IFIH1 rs1990760, CD40 rs48104850, TNFAIP3 rs2230926, and miR146-a rs2910164 were genotyped in 176 adult RA patients.” | 0.98 | hgnc_dict_v1 |
Characterization of Rheumatoid Arthritis Risk-Associated SNPs and Identification of Novel Therapeutic Sites Using an In-Silico Approach.
PMID 34199962 | PMCID PMC8227790 | DOI 10.3390/biology10060501 · Biology · 2021 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TNFAIP3 | “The damaging effect of 23 non-synonymous SNPs on proteins using different tools suggested four SNPs, including rs2476601 in PTPN22, rs5029941 and rs2230926 in TNFAIP3, and rs34536443 in TYK2, to be the most damaging.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “Characterization of Rheumatoid Arthritis Risk-Associated SNPs and Identification of Novel Therapeutic Sites Using an In-Silico Approach.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTPN22 | “The damaging effect of 23 non-synonymous SNPs on proteins using different tools suggested four SNPs, including rs2476601 in PTPN22, rs5029941 and rs2230926 in TNFAIP3, and rs34536443 in TYK2, to be the most damaging.” | 0.98 | hgnc_dict_v1 |
| gene | TYK2 | “The damaging effect of 23 non-synonymous SNPs on proteins using different tools suggested four SNPs, including rs2476601 in PTPN22, rs5029941 and rs2230926 in TNFAIP3, and rs34536443 in TYK2, to be the most damaging.” | 0.98 | hgnc_dict_v1 |