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TP53 and epilepsy are reported together in 1 article.
Gene
TP53
- HGNC
- HGNC:11998
219articles
219mentions
7variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 43colorectal cancer 32leukemia 10hepatocellular carcinoma 9ovarian cancer 6thyroid cancer 5lung cancer 4obesity 4
Reported variants (articles · ClinVar status)
Phenotype
Epilepsy
- HPO
- HP:0001250
2,084articles
2,084mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Exploring the multi-gene regulatory molecular mechanism of Saudi Arabian flora against epilepsy based on data mining, network pharmacology and docking analysis.
PMID 37638220 | PMCID PMC10448170 | DOI 10.1016/j.jsps.2023.101732 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “Following that, a compound-target protein-pathway network was constructed which uncovered that namely abrectorin, genistin, (+)-catechin, precatorine, (+)-ascorbic acid, licoflavanone, skrofulein, stigmasterone, 5,7-Dihydroxy-4'-methoxy-8,3'-di-C-prenylflavanone could potentially be used as antagonists for the therapeutic management of epilepsy by targeting TNF and TP53 proteins.” | 0.98 | hgnc_dict_v1 |
| phenotype | epilepsy | “Exploring the multi-gene regulatory molecular mechanism of Saudi Arabian flora against epilepsy based on data mining, network pharmacology and docking analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | ovarian cancer | “This data was then analyzed to identify common targets between the plants and ovarian cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Exploring the multi-gene regulatory molecular mechanism of Saudi Arabian flora against epilepsy based on data mining, network pharmacology and docking analysis. Epilepsy is a chronic neurological disorder marked by recurrent seizures, significantly affecting the population in Saudi Arabia across all age demographics. The current study integrates network pharmacology along with Bioinformatics approaches to explore the potential molecular mechanisms of local flora of Saudi Arabia including Solanum incanum, Abrus precatorius, Withania somnifera, and Azadirachta indica in epilepsy treatment.” | 0.95 | saudi_context_rules_v1 |