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TP53 and gastric cancer are reported together in 3 articles.
Gene
TP53
- HGNC
- HGNC:11998
219articles
219mentions
7variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 43colorectal cancer 32leukemia 10hepatocellular carcinoma 9ovarian cancer 6thyroid cancer 5lung cancer 4obesity 4
Reported variants (articles · ClinVar status)
Phenotype
Gastric cancer
106articles
106mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60STK11 and DNA Repair Gene Mutations Define Hereditary Subset of Middle Eastern Papillary Thyroid Cancer.
PMID 41898519 | PMCID PMC13026885 | DOI 10.3390/ijms27062656 · International journal of molecular sciences · 2026 · 16 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “Eleven patients (4.5%) harbored germline PVs/LPVs in cancer susceptibility genes including STK11, TP53, BRCA1, BRCA2, FANCA, SLX4, RAD50, MSH6, POLD1 and NF1.” | 0.98 | hgnc_dict_v1 |
| phenotype | gastric cancer | “A TP53 hotspot mutation (p.R175H) was identified in a patient with a personal history of gastric cancer, a malignancy associated with Li-Fraumeni syndrome.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | STK11 | “STK11 and DNA Repair Gene Mutations Define Hereditary Subset of Middle Eastern Papillary Thyroid Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Eleven patients (4.5%) harbored germline PVs/LPVs in cancer susceptibility genes including STK11, TP53, BRCA1, BRCA2, FANCA, SLX4, RAD50, MSH6, POLD1 and NF1.” | 0.98 | hgnc_dict_v1 |
P53-associated lncRNAs regulate immune functions and RNA-modifiers in gastric cancer.
PMID 39166030 | PMCID PMC11334848 | DOI 10.1016/j.heliyon.2024.e35228 · Heliyon · 2024 · 13 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “TP53, a guardian of the genome, suppresses or enhances tumors through various regulatory pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | gastric cancer | “P53-associated lncRNAs regulate immune functions and RNA-modifiers in gastric cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ZC3H13 | “Similarly, significant differences in immune function (APC_co_stimulation, CCR, and checkpoint) and m6A modification (FTO, ZC3H13, YTHDC1, and RBM15), and m5C modification (NOP2 and TET1) between both groups were also observed.” | 0.98 | hgnc_dict_v1 |
| gene | YTHDC1 | “Similarly, significant differences in immune function (APC_co_stimulation, CCR, and checkpoint) and m6A modification (FTO, ZC3H13, YTHDC1, and RBM15), and m5C modification (NOP2 and TET1) between both groups were also observed.” | 0.98 | hgnc_dict_v1 |
Li-Fraumeni Syndrome with Unusual Synchronous Malignancies: A Case Report.
PMID 38188481 | PMCID PMC10769503 | DOI 10.1159/000535099 · Case reports in oncology · 2024 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “INTRODUCTION: Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder brought on by pathogenic mutations in the TP53 tumor suppressor gene.” | 0.98 | hgnc_dict_v1 |
| phenotype | gastric cancer | “CONCLUSION: Gastric cancer and neuroendocrine tumors are not usually associated with LFS.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | leukemia | “CASE PRESENTATION: We are presenting a 48-year-old male with a diagnosis of LFS that was confirmed by a genetic test triggered by the patient's son's diagnosis of LFS and leukemia.” | 0.98 | phenotype_alias_lexicon_v2 |