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TP53 and hepatocellular carcinoma are reported together in 9 articles.
Gene
TP53
- HGNC
- HGNC:11998
219articles
219mentions
7variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 43colorectal cancer 32leukemia 10hepatocellular carcinoma 9ovarian cancer 6thyroid cancer 5lung cancer 4obesity 4
Reported variants (articles · ClinVar status)
Phenotype
Hepatocellular carcinoma
417articles
417mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
9 records shown · first 60Citrate-capped AuNPs-induced redox reprogramming modulates the TP53-BAX/BCL2-CASP3 Axis, reinforcing antioxidant defense and promoting apoptotic signaling in liver Cancer.
PMID 40627935 | DOI 10.1016/j.saa.2025.126630 · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “Gene expression analysis using qRT-PCR examined key apoptosis-related markers (TP53, BAX, BCL2, CASP3).” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Citrate-capped AuNPs-induced redox reprogramming modulates the TP53-BAX/BCL2-CASP3 Axis, reinforcing antioxidant defense and promoting apoptotic signaling in liver Cancer.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | BAX | “Gene expression analysis using qRT-PCR examined key apoptosis-related markers (TP53, BAX, BCL2, CASP3).” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Gene expression analysis using qRT-PCR examined key apoptosis-related markers (TP53, BAX, BCL2, CASP3).” | 0.98 | hgnc_dict_v1 |
Anthocyanins: From Natural Colorants to Potent Anticancer Agents.
PMID 40321606 | PMCID PMC12048707 | DOI 10.1002/fsn3.70232 · Food science & nutrition · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “Moreover, anthocyanins downregulate oncogenes (Bcl-2, MYC, and HER2) and improve the activity of tumor suppressor genes (TP53, BRCA1, and RB1).” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Anthocyanins, particularly cyanidin-3-O-glucoside, suppress inflammation and production of pro-inflammatory cytokines (COX-2, TNF-α, and IL-6) in colorectal cancer and hepatocellular carcinoma.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MYC | “Moreover, anthocyanins downregulate oncogenes (Bcl-2, MYC, and HER2) and improve the activity of tumor suppressor genes (TP53, BRCA1, and RB1).” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Moreover, anthocyanins downregulate oncogenes (Bcl-2, MYC, and HER2) and improve the activity of tumor suppressor genes (TP53, BRCA1, and RB1).” | 0.98 | hgnc_dict_v1 |
Genomic landscape in Saudi patients with hepatocellular carcinoma using whole-genome sequencing: a pilot study.
PMID 41821813 | PMCID PMC12952451 | DOI 10.3389/fgstr.2023.1205415 · Frontiers in gastroenterology (Lausanne, Switzerland) · 2023 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Genomic landscape in Saudi patients with hepatocellular carcinoma using whole-genome sequencing: a pilot study.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PIK3CA | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
| gene | APOB | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
Advanced network pharmacology study reveals multi-pathway and multi-gene regulatory molecular mechanism of Bacopa monnieri in liver cancer based on data mining, molecular modeling, and microarray data analysis.
PMID 37244150 | DOI 10.1016/j.compbiomed.2023.107059 · Computers in biology and medicine · 2023 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “In summary, we proposed that quercetin, luteolin, apigenin, catechin, epicatechin, stigmasterol, beta-sitosterol, celastrol, and betulic acid inhibit tumor growth by affecting tumor protein 53 (TP53), interleukin 6 (IL6), RAC-alpha serine/threonine protein kinases 1 (AKT1), caspase-3 (CASP3), tumor necrosis factor (TNF), jun proto-oncogene (JUN), heat shot protein 90 AA1 (HSP90AA1), vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor (EGFR), and SRC proto-oncogene (SRC).” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Advanced network pharmacology study reveals multi-pathway and multi-gene regulatory molecular mechanism of Bacopa monnieri in liver cancer based on data mining, molecular modeling, and microarray data analysis.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | AKT1 | “In summary, we proposed that quercetin, luteolin, apigenin, catechin, epicatechin, stigmasterol, beta-sitosterol, celastrol, and betulic acid inhibit tumor growth by affecting tumor protein 53 (TP53), interleukin 6 (IL6), RAC-alpha serine/threonine protein kinases 1 (AKT1), caspase-3 (CASP3), tumor necrosis factor (TNF), jun proto-oncogene (JUN), heat shot protein 90 AA1 (HSP90AA1), vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor (EGFR), and SRC proto-oncogene (SRC).” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “In summary, we proposed that quercetin, luteolin, apigenin, catechin, epicatechin, stigmasterol, beta-sitosterol, celastrol, and betulic acid inhibit tumor growth by affecting tumor protein 53 (TP53), interleukin 6 (IL6), RAC-alpha serine/threonine protein kinases 1 (AKT1), caspase-3 (CASP3), tumor necrosis factor (TNF), jun proto-oncogene (JUN), heat shot protein 90 AA1 (HSP90AA1), vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor (EGFR), and SRC proto-oncogene (SRC).” | 0.98 | hgnc_dict_v1 |
Transcriptional Analysis of TP53 Gene in Chronic Hepatitis C Patients Treated with Sofosbuvir, Daclatasvir, Pegylated Interferon, and Ribavirin.
PMID 37125127 | PMCID PMC10134244 | DOI 10.1021/acsomega.3c00903 · ACS omega · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “Transcriptional Analysis of TP53 Gene in Chronic Hepatitis C Patients Treated with Sofosbuvir, Daclatasvir, Pegylated Interferon, and Ribavirin.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “HCV is a principal cause of hepatocellular carcinoma (HCC) around the globe due to the high frequency of hepatitis C infection, and the high rate of HCC is seen in patients with HCV cirrhosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hepatitis C | “Transcriptional Analysis of TP53 Gene in Chronic Hepatitis C Patients Treated with Sofosbuvir, Daclatasvir, Pegylated Interferon, and Ribavirin.” | 0.98 | phenotype_alias_lexicon_v2 |
Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma.
PMID 36479247 | PMCID PMC9720179 | DOI 10.3389/fgene.2022.880440 · Frontiers in genetics · 2022 · 15 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “We also find that ADCY8, MYC, PTK2, CTNNB1, TP53, RB1, PRKCA, TCF7L2, PAK1, ITPR2, CYP3A4, UGT1A6, GCK, and FGFR2/3 appear to be among the prominent genes based on the networks of genes and pathways based on the copy number alterations, mutations, and structural variants study.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ADCY8 | “We also find that ADCY8, MYC, PTK2, CTNNB1, TP53, RB1, PRKCA, TCF7L2, PAK1, ITPR2, CYP3A4, UGT1A6, GCK, and FGFR2/3 appear to be among the prominent genes based on the networks of genes and pathways based on the copy number alterations, mutations, and structural variants study.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “We also find that ADCY8, MYC, PTK2, CTNNB1, TP53, RB1, PRKCA, TCF7L2, PAK1, ITPR2, CYP3A4, UGT1A6, GCK, and FGFR2/3 appear to be among the prominent genes based on the networks of genes and pathways based on the copy number alterations, mutations, and structural variants study.” | 0.98 | hgnc_dict_v1 |
Bursatella leachii Purple Ink Secretion Concentrate Exerts Cytotoxic Properties against Human Hepatocarcinoma Cell Line (HepG2): In Vitro and In Silico Studies.
PMID 35164089 | PMCID PMC8839718 | DOI 10.3390/molecules27030826 · Molecules (Basel, Switzerland) · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “The gene expression levels of pro-apoptotic BAX, TP53 and Cyclin D1 were increased after treatment with the B. leachii ink concentrate.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Liver cancer is a leading cause of cancer death globally.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | BAX | “The gene expression levels of pro-apoptotic BAX, TP53 and Cyclin D1 were increased after treatment with the B. leachii ink concentrate.” | 0.98 | hgnc_dict_v1 |
Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.
PMID 35197752 | PMCID PMC8847977 | DOI 10.1016/j.sjbs.2021.10.022 · Saudi journal of biological sciences · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PIK3CA | “Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.” | 0.98 | hgnc_dict_v1 |
Correlation between clinical characteristics, survival and genetic alterations in patients with hepatocellular carcinoma from Saudi Arabia.
PMID 21156243 | DOI 10.1016/j.cancergencyto.2010.08.011 · Cancer genetics and cytogenetics · 2010 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “Amplification of the two oncogenes ERBB2 and MYC and deletion of the tumor suppressor gene TP53 are frequently encountered in cancerous tissues.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Correlation between clinical characteristics, survival and genetic alterations in patients with hepatocellular carcinoma from Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ERBB2 | “Amplification of the two oncogenes ERBB2 and MYC and deletion of the tumor suppressor gene TP53 are frequently encountered in cancerous tissues.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Amplification of the two oncogenes ERBB2 and MYC and deletion of the tumor suppressor gene TP53 are frequently encountered in cancerous tissues.” | 0.98 | hgnc_dict_v1 |