Type	Entity	Source evidence	Confidence	Extractor
gene	TREM2	“So, approaches that potentiate the protective effects of APOE, like APOE mimetics, ABCA1 agonists, targeting APOE receptors like LDLR, LRP1, APOER2, and TREM2, might offer significant therapeutic benefits in Alzheimer's disease.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.”	0.93	phenotype_alias_lexicon_v2
gene	APOE	“Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.”	0.98	hgnc_dict_v1
gene	LDLR	“One of the key functions of APOE is to bind and deliver newly synthesized cholesterol and lipids to neurons through receptor-mediated endocytosis (LDLR, LRP1, VLDLR, APOER2).”	0.98	hgnc_dict_v1

PMID 41792456 | PMCID PMC13268972 | DOI 10.1038/s41380-026-03505-7 · Molecular psychiatry · 2026 · 3 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TREM2	“TREM2 in neurodegeneration and diseases.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“TREM2-initiated signaling plays a crucial role in regulating neuroinflammation and neurodegeneration, particularly in the context of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), through the activation of downstream signaling pathways and transcriptional regulation of relevant genes.”	0.93	phenotype_alias_lexicon_v2
phenotype	Parkinson disease	“TREM2-initiated signaling plays a crucial role in regulating neuroinflammation and neurodegeneration, particularly in the context of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), through the activation of downstream signaling pathways and transcriptional regulation of relevant genes.”	0.93	phenotype_alias_lexicon_v2

PMID 40120784 | DOI 10.1016/j.mcn.2025.104005 · Molecular and cellular neurosciences · 2025 · 2 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TREM2	“Critical analysis is presented for therapeutic strategies targeting GSK-3β using natural compounds (e.g., curcumin, geniposide) and emerging approaches such as TREM2 modulation and miRNA therapies.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“GSK-3β dysregulation in aging: Implications for tau pathology and Alzheimer's disease progression.”	0.93	phenotype_alias_lexicon_v2

PMID 39342887 | DOI 10.1016/j.prp.2024.155614 · Pathology, research and practice · 2024 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TREM2	“Genetic polymorphisms in TREM2, APOE, and CD33 highlight the significant impact of microglial dysfunction in AD.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“Therapeutic approaches to microglial dysfunction in Alzheimer's disease: Enhancing phagocytosis and metabolic regulation.”	0.93	phenotype_alias_lexicon_v2
gene	APOE	“Genetic polymorphisms in TREM2, APOE, and CD33 highlight the significant impact of microglial dysfunction in AD.”	0.98	hgnc_dict_v1
gene	CD33	“Genetic polymorphisms in TREM2, APOE, and CD33 highlight the significant impact of microglial dysfunction in AD.”	0.98	hgnc_dict_v1

PMID 31594217 | DOI 10.3233/JAD-181259 · Journal of Alzheimer's disease : JAD · 2019 · 3 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TREM2	“NLRP3 and TREM2 expression was analyzed by RT-PCR; phagocytosis, as well as ASC-Speck formation, was analyzed by Amnis FlowSight Imaging; NLRP3-produced cytokines were quantified by ELISA and, finally, autophagy was analyzed by measuring p-ERK1/2, p-AKT, beclin, p70-S6Kinase, and Lamp by ELISA and western blot.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“BACKGROUND: Alzheimer's disease (AD) is associated with the accumulation of amyloid-β (Aβ) within senile plaques in the brain and neuroinflammation, possibly driven by the activation of the NLRP3 inflammasome.”	0.93	phenotype_alias_lexicon_v2
gene	NLRP3	“Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy.”	0.98	hgnc_dict_v1

PMID 25664220 | PMCID PMC4317331 | DOI 10.4172/2161-0460.1000160 · Journal of Alzheimer's disease & Parkinsonism · 2014 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TREM2	“The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders.”	0.93	phenotype_alias_lexicon_v2
phenotype	hypertension	“Other environmental risk factors include diabetes mellitus, level of physical activity, educational status, hypertension and head injury.”	0.98	phenotype_alias_lexicon_v2
phenotype	diabetes mellitus	“Other environmental risk factors include diabetes mellitus, level of physical activity, educational status, hypertension and head injury.”	0.98	phenotype_alias_lexicon_v2

PMID 24663666 | PMCID PMC3963925 | DOI 10.1371/journal.pone.0092648 · PloS one · 2014 · 3 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TREM2	“Our results showed the alteration caused due to the variant in TREM2 protein has significant effect on the ligand binding affinity as well as structural configuration.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“Evidence of trem2 variant associated with triple risk of Alzheimer's disease.”	0.93	phenotype_alias_lexicon_v2
variant	rs75932628	“The rare variant discovered is a missense mutation in the loop region of exon 2 of Trem2 (rs75932628-T, Arg47His).”	0.90	hgvs_regex_v1

PMID 24223593 | PMCID PMC3809371 | DOI 10.1155/2013/576383 · International journal of cell biology · 2013 · 3 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TREM2	“Recently, it has been reported by two groups independently that a rare functional variant (R47H) of TREM2 is associated with the late-onset risk of AD.”	0.98	hgnc_dict_v1
phenotype	Alzheimer disease	“The innate immune system in Alzheimer's disease.”	0.93	phenotype_alias_lexicon_v2
variant	R47H	“Recently, it has been reported by two groups independently that a rare functional variant (R47H) of TREM2 is associated with the late-onset risk of AD.”	0.82	literature_variant_regex_v2