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TREM2 and Parkinson disease are reported together in 1 article.
Gene
TREM2
- HGNC
- HGNC:17761
10articles
10mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Parkinson disease
280articles
280mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60TREM2 in neurodegeneration and diseases.
PMID 41792456 | PMCID PMC13268972 | DOI 10.1038/s41380-026-03505-7 · Molecular psychiatry · 2026 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TREM2 | “TREM2 in neurodegeneration and diseases.” | 0.98 | hgnc_dict_v1 |
| phenotype | Parkinson disease | “TREM2-initiated signaling plays a crucial role in regulating neuroinflammation and neurodegeneration, particularly in the context of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), through the activation of downstream signaling pathways and transcriptional regulation of relevant genes.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | Alzheimer disease | “TREM2-initiated signaling plays a crucial role in regulating neuroinflammation and neurodegeneration, particularly in the context of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), through the activation of downstream signaling pathways and transcriptional regulation of relevant genes.” | 0.93 | phenotype_alias_lexicon_v2 |