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TYK2 and COVID-19 are reported together in 1 article.
Gene
TYK2
- HGNC
- HGNC:12440
15articles
15mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
atopic dermatitis 2inflammatory bowel disease 2rheumatoid arthritis 2COVID-19 1Crohn disease 1diabetes mellitus 1tuberculosis 1ulcerative colitis 1
Reported variants (articles · ClinVar status)
Phenotype
COVID-19
1,317articles
1,317mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.
PMID 37020259 | PMCID PMC10074346 | DOI 10.1186/s13073-023-01173-8 · Genome medicine · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TYK2 | “This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1-2635.4], P = 3.4 × 10-3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3-8.4], P = 7.7 × 10-8).” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TLR7 | “Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P = 1.1 × 10-4) for biochemically loss-of-function (bLOF) variants.” | 0.98 | hgnc_dict_v1 |