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TYK2 and Crohn disease are reported together in 1 article.
Gene
TYK2
- HGNC
- HGNC:12440
15articles
15mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
atopic dermatitis 2inflammatory bowel disease 2rheumatoid arthritis 2COVID-19 1Crohn disease 1diabetes mellitus 1tuberculosis 1ulcerative colitis 1
Reported variants (articles · ClinVar status)
Phenotype
Crohn disease
435articles
435mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60High-Throughput Whole-Exome Sequencing and Large-Scale Computational Analysis to Identify the Genetic Biomarkers to Predict the Vedolizumab Response Status in Inflammatory Bowel Disease Patients from Saudi Arabia.
PMID 40002872 | PMCID PMC11852680 | DOI 10.3390/biomedicines13020459 · Biomedicines · 2025 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TYK2 | “Rare variants of CARD9, TYK2, IL4, and NLRP1 genes present in VDZ responders enhance the anti-inflammatory/immune modulation effects.” | 0.98 | hgnc_dict_v1 |
| phenotype | Crohn disease | “Methods: A cohort of 16 patients with IBD, including 4 with Crohn's disease and 12 with ulcerative colitis, were recruited.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | NOD2 | “The rare variant analysis prioritized NOD2, IL23, IL10, IL27, and TRAF1 genes in non-responders.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “The rare variant analysis prioritized NOD2, IL23, IL10, IL27, and TRAF1 genes in non-responders.” | 0.98 | hgnc_dict_v1 |