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TYK2 and inflammatory bowel disease are reported together in 2 articles.
Gene
TYK2
- HGNC
- HGNC:12440
15articles
15mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
atopic dermatitis 2inflammatory bowel disease 2rheumatoid arthritis 2COVID-19 1Crohn disease 1diabetes mellitus 1tuberculosis 1ulcerative colitis 1
Reported variants (articles · ClinVar status)
Phenotype
Inflammatory bowel disease
693articles
693mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60High-Throughput Whole-Exome Sequencing and Large-Scale Computational Analysis to Identify the Genetic Biomarkers to Predict the Vedolizumab Response Status in Inflammatory Bowel Disease Patients from Saudi Arabia.
PMID 40002872 | PMCID PMC11852680 | DOI 10.3390/biomedicines13020459 · Biomedicines · 2025 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TYK2 | “Rare variants of CARD9, TYK2, IL4, and NLRP1 genes present in VDZ responders enhance the anti-inflammatory/immune modulation effects.” | 0.98 | hgnc_dict_v1 |
| phenotype | inflammatory bowel disease | “High-Throughput Whole-Exome Sequencing and Large-Scale Computational Analysis to Identify the Genetic Biomarkers to Predict the Vedolizumab Response Status in Inflammatory Bowel Disease Patients from Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | NOD2 | “The rare variant analysis prioritized NOD2, IL23, IL10, IL27, and TRAF1 genes in non-responders.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “The rare variant analysis prioritized NOD2, IL23, IL10, IL27, and TRAF1 genes in non-responders.” | 0.98 | hgnc_dict_v1 |
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.
PMID 26304966 | PMCID PMC4577846 | DOI 10.1084/jem.20140280 · The Journal of experimental medicine · 2015 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TYK2 | “Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.” | 0.98 | hgnc_dict_v1 |
| phenotype | inflammatory bowel disease | “All eight TYK2-deficient patients displayed impaired but not abolished cellular responses to (a) IL-12 and IFN-α/β, accounting for mycobacterial and viral infections, respectively; (b) IL-23, with normal proportions of circulating IL-17(+) T cells, accounting for their apparent lack of mucocutaneous candidiasis; and (c) IL-10, with no overt clinical consequences, including a lack of inflammatory bowel disease.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | atopic dermatitis | “Autosomal recessive, complete TYK2 deficiency was previously described in a patient (P1) with intracellular bacterial and viral infections and features of hyper-IgE syndrome (HIES), including atopic dermatitis, high serum IgE levels, and staphylococcal abscesses.” | 0.98 | phenotype_alias_lexicon_v2 |