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TYK2 and tuberculosis are reported together in 1 article.
Gene
TYK2
- HGNC
- HGNC:12440
15articles
15mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
atopic dermatitis 2inflammatory bowel disease 2rheumatoid arthritis 2COVID-19 1Crohn disease 1diabetes mellitus 1tuberculosis 1ulcerative colitis 1
Reported variants (articles · ClinVar status)
Phenotype
Tuberculosis
405articles
405mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Consanguineous marriages increase the incidence of recurrent tuberculosis: Evidence from whole exome sequencing.
PMID 38266757 | DOI 10.1016/j.meegid.2024.105559 · Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TYK2 | “Moreover, the study suggests at the potential role of other related genes such as IL-23Rβ1, TYK2, or JAK2 in IFN-γ production, warranting further investigation.” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “Consanguineous marriages increase the incidence of recurrent tuberculosis: Evidence from whole exome sequencing.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | JAK2 | “Moreover, the study suggests at the potential role of other related genes such as IL-23Rβ1, TYK2, or JAK2 in IFN-γ production, warranting further investigation.” | 0.98 | hgnc_dict_v1 |
| population | Population | “Consanguineous marriages increase the incidence of recurrent tuberculosis: Evidence from whole exome sequencing. BACKGROUND: In this study, we have identified multiple mutations in the IL-12R1 gene among Pakistani patients who have inherited them through consanguineous marriages. Among Pakistani patients born to consanguineous marriages, the identified mutations in the IL-12Rβ-1 gene provide insights into the genetic basis of severe BCG infections and recurrent tuberculosis.” | 0.80 | saudi_context_rules_v1 |