Type	Entity	Source evidence	Confidence	Extractor
gene	UCP1	“Modulatory Role of Moringa Oleifera-Loaded Silver Nanoparticles on UCP1 and PPARGC1A Genes Expression in an Obesity Rat Model.”	0.98	hgnc_dict_v1
phenotype	obesity	“Modulatory Role of Moringa Oleifera-Loaded Silver Nanoparticles on UCP1 and PPARGC1A Genes Expression in an Obesity Rat Model.”	0.98	phenotype_alias_lexicon_v2
gene	PPARGC1A	“Modulatory Role of Moringa Oleifera-Loaded Silver Nanoparticles on UCP1 and PPARGC1A Genes Expression in an Obesity Rat Model.”	0.98	hgnc_dict_v1

PMID 32197395 | PMCID PMC7146519 | DOI 10.3390/nu12030803 · Nutrients · 2020 · 3 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	UCP1	“Commiphora myrrha Resin Alcoholic Extract Ameliorates High Fat Diet Induced Obesity via Regulation of UCP1 and Adiponectin Proteins Expression in Rats.”	0.98	hgnc_dict_v1
phenotype	obesity	“Commiphora myrrha Resin Alcoholic Extract Ameliorates High Fat Diet Induced Obesity via Regulation of UCP1 and Adiponectin Proteins Expression in Rats.”	0.98	phenotype_alias_lexicon_v2
phenotype	dyslipidemia	“In contrast, CME ameliorated HFD increased body weight, hyperglycemia, dyslipidemia, ketonemia, hepatic tissues lipid peroxidation, restored hepatic tissue architecture and enhanced protein expression of leptin, adiponectin and UCP1 and activity of hepatic GR.”	0.98	phenotype_alias_lexicon_v2

PMID 31572455 | PMCID PMC6764296 | DOI 10.5114/aoms.2018.76684 · Archives of medical science : AMS · 2019 · 7 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	UCP1	“Whereas the correlation of UCP1 with BMI remained insignificant (r = -0.29, p = 0.08).”	0.98	hgnc_dict_v1
phenotype	obesity	“INTRODUCTION: The molecular mechanisms behind obesity pathogenesis remain largely undefined.”	0.98	phenotype_alias_lexicon_v2
gene	FGF21	“Serum FGF21 was measured using an ELISA kit, and the serum blood lipid profile was measured using the Dimension VistaTM 1500 System.”	0.98	hgnc_dict_v1
gene	CIDEA	“The expression of CIDEA and CITED1 was significantly higher in the patients with normal weight as compared to obese (p = 0.01 and p = 0.02, respectively).”	0.98	hgnc_dict_v1

PMID 30458724 | PMCID PMC6247512 | DOI 10.1186/s12881-018-0715-5 · BMC medical genetics · 2018 · 13 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	UCP1	“Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study.”	0.98	hgnc_dict_v1
phenotype	obesity	“Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study.”	0.98	phenotype_alias_lexicon_v2
gene	NPC1	“The aim of this study was to determine the effect of selected genetic polymorphisms in Uncoupling protein 1 (UCP1) and Niemann-Pick C1 (NPC1) genes in an obese population in Saudi Arabia.”	0.98	hgnc_dict_v1
phenotype	Niemann-Pick disease	“The aim of this study was to determine the effect of selected genetic polymorphisms in Uncoupling protein 1 (UCP1) and Niemann-Pick C1 (NPC1) genes in an obese population in Saudi Arabia.”	0.93	phenotype_alias_lexicon_v2

PMID 29264745 | PMCID PMC6066287 | DOI 10.1007/s10753-017-0718-y · Inflammation · 2018 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	UCP1	“In addition, activation of NLRP3 inflammasome in macrophages attenuated UCP1 induction and mitochondrial respiration in cultures of primary adipocytes, while the absence of NLRP3 protected UCP1 in adipocytes.”	0.98	hgnc_dict_v1
phenotype	obesity	“Adipose tissue expansion is accompanied by infiltration and accumulation of pro-inflammatory macrophages, which links obesity to pathologic conditions such as type 2 diabetes.”	0.98	phenotype_alias_lexicon_v2
gene	NLRP3	“Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning.”	0.98	hgnc_dict_v1
gene	TLR4	“Here, we investigated the effect of pattern recognition receptors (PRR) activation in macrophages, especially the toll-like receptor 4 (TLR4) and Nod-like receptor 3 (NLRP3), on white adipocyte browning.”	0.98	hgnc_dict_v1

PMID 27621146 | DOI 10.1016/j.biochi.2016.09.007 · Biochimie · 2017 · 2 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	UCP1	“Investigations in the mid-late 1970s established the uncoupling of oxidative phosphorylation through a proton conductance pathway across the mitochondrial inner membrane as the mechanism for heat production in BAT, this being regulated by UCP1 which was first discovered as a 32,000 Mr cold-inducible protein.”	0.98	hgnc_dict_v1
phenotype	obesity	“Origins and early development of the concept that brown adipose tissue thermogenesis is linked to energy balance and obesity.”	0.98	phenotype_alias_lexicon_v2

PMID 25745415 | PMCID PMC4333869 | DOI 10.3389/fendo.2015.00019 · Frontiers in endocrinology · 2015 · 3 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	UCP1	“Hypoxia-induced augmentation of lactate production may also stimulate the "browning" of white fat depots through recruitment of UCP1 and the development of brite adipocytes.”	0.98	hgnc_dict_v1
phenotype	obesity	“Oxygen deprivation and the cellular response to hypoxia in adipocytes - perspectives on white and brown adipose tissues in obesity.”	0.98	phenotype_alias_lexicon_v2
phenotype	metabolic syndrome	“This would be expected to compromise thermogenic activity and the role of brown fat in glucose homeostasis and triglyceride clearance, underpinning the development of the metabolic syndrome.”	0.98	phenotype_alias_lexicon_v2