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ULK1 and Crohn disease are reported together in 1 article.
Gene
ULK1
- HGNC
- HGNC:12558
9articles
9mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Crohn disease
435articles
435mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60ULK1-mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant.
PMID 31267703 | PMCID PMC6607016 | DOI 10.15252/embr.201846885 · EMBO reports · 2019 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ULK1 | “Here we show that ULK1 kinase directly phosphorylates ATG16L1 in response to infection and starvation.” | 0.98 | hgnc_dict_v1 |
| phenotype | Crohn disease | “ATG16L1 polymorphisms have been linked to the development of Crohn's disease (CD), and phosphorylation of CD-associated ATG16L1 T300A (caATG16L1) has been hypothesized to contribute to cleavage and autophagy dysfunction.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | ATG16L1 | “ULK1-mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant.” | 0.98 | hgnc_dict_v1 |
| variant | T300A | “ATG16L1 polymorphisms have been linked to the development of Crohn's disease (CD), and phosphorylation of CD-associated ATG16L1 T300A (caATG16L1) has been hypothesized to contribute to cleavage and autophagy dysfunction.” | 0.82 | literature_variant_regex_v2 |