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VDR and metabolic syndrome are reported together in 2 articles.
Gene
VDR
- HGNC
- HGNC:12679
87articles
87mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
diabetes mellitus 16obesity 6COVID-19 3tuberculosis 3breast cancer 2colorectal cancer 2hepatocellular carcinoma 2hypertension 2
Reported variants (articles · ClinVar status)
Phenotype
Metabolic syndrome
141articles
141mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60The Association Between FokI Vitamin D Receptor Polymorphisms With Metabolic Syndrome Among Pregnant Arab Women.
PMID 35282461 | PMCID PMC8909137 | DOI 10.3389/fendo.2022.844472 · Frontiers in endocrinology · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | VDR | “The link between vitamin D receptor (VDR) gene polymorphisms and maternal MetS has been observed in several ethnic groups, but is yet to be clarified in the Arabian population.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “The Association Between FokI Vitamin D Receptor Polymorphisms With Metabolic Syndrome Among Pregnant Arab Women.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Metabolic syndrome (MetS) is a serious health condition that is becoming extremely threatening in Saudi Arabia. This study aims to investigate the relationship between the FokI VDR genotype and the risk of MetS and its components in pregnant Saudi women. A cross-sectional study was conducted using 368 pregnant Saudi women on first trimester screened for MetS (44 with MetS and 324 without MetS).” | 0.95 | saudi_context_rules_v1 |
Association of VDR-gene variants with factors related to the metabolic syndrome, type 2 diabetes and vitamin D deficiency.
PMID 24680778 | DOI 10.1016/j.gene.2014.03.044 · Gene · 2014 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | VDR | “This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and genetic susceptibility to components of the metabolic syndrome, type 2 diabetes mellitus (T2DM), and vitamin D deficiency in the Saudi Arabian population.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “Association of VDR-gene variants with factors related to the metabolic syndrome, type 2 diabetes and vitamin D deficiency.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | obesity | “The CT genotype and allele T of BsmI were associated with lower HDL-C levels [OR 0.60 (0.37, 0.96), p=0.03] and obesity [OR 1.4 (1.0, 1.90), p=0.04], respectively.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “Association of VDR-gene variants with factors related to the metabolic syndrome, type 2 diabetes and vitamin D deficiency.” | 0.93 | phenotype_alias_lexicon_v2 |