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VPS35 and Parkinson disease are reported together in 2 articles.
Gene
VPS35
- HGNC
- HGNC:13487
2articles
2mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Parkinson disease
280articles
280mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Oxidative Stress and Dopaminergic Metabolism: A Major PD Pathogenic Mechanism and Basis of Potential Antioxidant Therapies.
PMID 37303175 | DOI 10.2174/1871527322666230609141519 · CNS & neurological disorders drug targets · 2024 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | VPS35 | “The mutations in genes such as DNAJC6, SYNJ1, SH3GL2, LRRK2, PRKN, and VPS35 caused by ROS have been associated with synaptic dysfunction and the pathogenesis of Parkinson's disease (PD).” | 0.98 | hgnc_dict_v1 |
| phenotype | Parkinson disease | “Oxidative Stress and Dopaminergic Metabolism: A Major PD Pathogenic Mechanism and Basis of Potential Antioxidant Therapies.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | DNAJC6 | “The mutations in genes such as DNAJC6, SYNJ1, SH3GL2, LRRK2, PRKN, and VPS35 caused by ROS have been associated with synaptic dysfunction and the pathogenesis of Parkinson's disease (PD).” | 0.98 | hgnc_dict_v1 |
| gene | SYNJ1 | “The mutations in genes such as DNAJC6, SYNJ1, SH3GL2, LRRK2, PRKN, and VPS35 caused by ROS have been associated with synaptic dysfunction and the pathogenesis of Parkinson's disease (PD).” | 0.98 | hgnc_dict_v1 |
Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort.
PMID 36692014 | DOI 10.1002/mds.29288 · Movement disorders : official journal of the Movement Disorder Society · 2023 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | VPS35 | “METHODS: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data.” | 0.98 | hgnc_dict_v1 |
| phenotype | Parkinson disease | “Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | SNCA | “METHODS: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data.” | 0.98 | hgnc_dict_v1 |
| gene | LRRK2 | “METHODS: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data.” | 0.98 | hgnc_dict_v1 |