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WT1 and renal failure are reported together in 2 articles.
Gene
WT1
- HGNC
- HGNC:12796
17articles
17mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Renal failure
523articles
523mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Denys-Drash Syndrome by WT1 Gene: Clinical Variability and Management Challenges in Two Saudi Infants.
PMID 42040317 | PMCID PMC13108425 | DOI 10.1155/crie/8875066 · Case reports in endocrinology · 2026 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | WT1 | “Denys-Drash Syndrome by WT1 Gene: Clinical Variability and Management Challenges in Two Saudi Infants.” | 0.98 | hgnc_dict_v1 |
| phenotype | renal failure | “BACKGROUND: Denys-Drash syndrome (DDS) is a rare genetic disorder characterized by mutations in the Wilms tumor suppressor gene (WT1), leading to a triad of conditions including nephrotic syndrome progressing to end-stage renal disease (ESRD), Wilms tumor, and ambiguous genitalia.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | nephrotic syndrome | “BACKGROUND: Denys-Drash syndrome (DDS) is a rare genetic disorder characterized by mutations in the Wilms tumor suppressor gene (WT1), leading to a triad of conditions including nephrotic syndrome progressing to end-stage renal disease (ESRD), Wilms tumor, and ambiguous genitalia.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | COVID-19 | “Despite surgical interventions, treatment was delayed due to COVID-19 restrictions, and the patient unfortunately passed away at 16 months during the lockdown period.” | 0.98 | phenotype_alias_lexicon_v2 |
Generation of Monogenic Candidate Genes for Human Nephrotic Syndrome Using 3 Independent Approaches.
PMID 33615071 | PMCID PMC7879125 | DOI 10.1016/j.ekir.2020.11.013 · Kidney international reports · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | WT1 | “Second, we used a set of 64 genes that are regulated by the transcription factor Wilms tumor 1 (WT1), which causes SRNS if mutated.” | 0.98 | hgnc_dict_v1 |
| phenotype | renal failure | “INTRODUCTION: Steroid-resistant nephrotic syndrome (SRNS) is the second most common cause of chronic kidney disease during childhood.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | SYNPO | “Using this approach, we identified 7 overlapping genes, of which 3 genes were shared by all datasets, including SYNPO.” | 0.98 | hgnc_dict_v1 |
| gene | CDC42 | “We show that loss-of-function of SYNPO leads to decreased CDC42 activity and reduced podocyte migration rate, both of which are rescued by overexpression of wild-type complementary DNA (cDNA), but not by cDNA representing the patient mutation.” | 0.98 | hgnc_dict_v1 |