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XIAP and leukemia are reported together in 1 article.
Gene
XIAP
- HGNC
- HGNC:592
34articles
34mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60An HuR mutant, HuR-V225I, identified in adult T-cell Leukemia/Lymphoma, alters the pro-apoptotic function of HuR.
PMID 39695179 | PMCID PMC11655865 | DOI 10.1038/s41420-024-02268-w · Cell death discovery · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | XIAP | “Finally, expression of the HuR-V225I mutant decreases the cell's response to apoptotic stimuli through the increased expression of mRNAs encoding anti-apoptotic factors, such as XIAP and BCL-2.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “An HuR mutant, HuR-V225I, identified in adult T-cell Leukemia/Lymphoma, alters the pro-apoptotic function of HuR.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | lymphoma | “An HuR mutant, HuR-V225I, identified in adult T-cell Leukemia/Lymphoma, alters the pro-apoptotic function of HuR.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | V225I | “Here, we show that a HuR mutation, HuR-V225I, previously identified in a patient with Adult T-cell Leukemia/Lymphoma, interferes with the pro-apoptotic function of HuR.” | 0.82 | literature_variant_regex_v2 |