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XIAP and ovarian cancer are reported together in 4 articles.
Gene
XIAP
- HGNC
- HGNC:592
34articles
34mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Ovarian cancer
173articles
173mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma.
PMID 20661229 | DOI 10.1038/labinvest.2010.136 · Laboratory investigation; a journal of technical methods and pathology · 2011 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | XIAP | “Using immunohistochemistry, c-Met overexpression was found in 27.2% Middle Eastern EOC samples and was associated with an advanced tumor stage (P=0.0187). c-Met overexpression was also associated with antiapoptotic markers X-chromosome-linked inhibitors of apoptosis (XIAP) (P=0.0008) and Bcl-XL (P=0.0493) expression.” | 0.98 | hgnc_dict_v1 |
| phenotype | ovarian cancer | “HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Therefore, we investigated the role of HGF/c-Met signaling pathway in a large series (156) of Saudi EOC patient samples, a panel of cell lines, and xenografts in a NUDE mouse model.” | 0.95 | saudi_context_rules_v1 |
Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis.
PMID 21442130 | PMCID PMC3146599 | DOI 10.2119/molmed.2011.00046 · Molecular medicine (Cambridge, Mass.) · 2011 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | XIAP | “Overexpression of FASN was associated significantly with tumor proliferative marker Ki-67 (P = 0.0009), activated AKT (P = 0.0117) and XIAP (P = 0.0046).” | 0.98 | hgnc_dict_v1 |
| phenotype | ovarian cancer | “Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | FASN | “Fatty acid synthase (FASN), the enzyme responsible for de novo synthesis of fatty acids, has been shown to be deregulated in several cancers, including epithelial ovarian carcinoma (EOC).” | 0.98 | hgnc_dict_v1 |
Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation in epithelial ovarian cancer.
PMID 19636294 | DOI 10.1038/labinvest.2009.75 · Laboratory investigation; a journal of technical methods and pathology · 2009 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | XIAP | “Bortezomib treatment of EOC cells causes apoptosis by involving mitochondrial pathway, activation of caspases and downregulation of XIAP, and survivin.” | 0.98 | hgnc_dict_v1 |
| phenotype | ovarian cancer | “Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation in epithelial ovarian cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SKP2 | “S-phase kinase protein 2 (SKP2), an F-box protein, targets cell-cycle regulators including cyclin-dependent kinase inhibitor p27Kip1 through ubiquitin-mediated degradation.” | 0.98 | hgnc_dict_v1 |
Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer.
PMID 19765303 | PMCID PMC2754986 | DOI 10.1186/1476-4598-8-74 · Molecular cancer · 2009 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | XIAP | “Furthermore, Ob-R expression was associated with anti apoptotic proteins Bcl-XL (p = 0.0035) and XIAP (p = 0.0001).” | 0.98 | hgnc_dict_v1 |
| phenotype | ovarian cancer | “Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | obesity | “BACKGROUND: Recent epidemiological studies have suggested that obesity is associated with ovarian cancer.” | 0.98 | phenotype_alias_lexicon_v2 |