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ZBTB7A and sickle cell disease are reported together in 1 article.

Gene

ZBTB7A

2articles

2mentions

0variants with confirmed gene link

Most co-reported phenotypes (articles)

Phenotype

828articles

828mentions

12co-reported genes shown

Most co-reported genes (articles)

Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.

1 records shown · first 60

PMID 39996784 | PMCID PMC11854342 | DOI 10.3390/cells14040312 · Cells · 2025 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	ZBTB7A	“Key regulators, like BCL11A and ZBTB7A, repress γ-globin expression to facilitate this transition with other factors, like KLF1, LSD1, and PGC-1α; these regulators ensure an orchestrated transition from γ- to β-globin during development.”	0.98	hgnc_dict_v1
phenotype	sickle cell disease	“Understanding how circRNAs contribute to switching from γ- to β-globin could lead to new therapeutic strategies for hemoglobinopathies, such as sickle cell disease and β-thalassemia.”	0.98	phenotype_alias_lexicon_v2
gene	BCL11A	“Key regulators, like BCL11A and ZBTB7A, repress γ-globin expression to facilitate this transition with other factors, like KLF1, LSD1, and PGC-1α; these regulators ensure an orchestrated transition from γ- to β-globin during development.”	0.98	hgnc_dict_v1
gene	KLF1	“Key regulators, like BCL11A and ZBTB7A, repress γ-globin expression to facilitate this transition with other factors, like KLF1, LSD1, and PGC-1α; these regulators ensure an orchestrated transition from γ- to β-globin during development.”	0.98	hgnc_dict_v1