TLR4
HGNC:11850 · 176 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR4 | “Spinosin Attenuates DSS-Induced Ulcerative Colitis in Rats in Association with Increased Nrf2/HO-1 and Reduced TLR4/NFKB1-Related Inflammatory Markers.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Biochemical analysis revealed significantly elevated levels of the immunomodulatory cytokines IL-10, IL-12, and IFN-γ, along with other immunity-related parameters, and molecular analysis showed upregulation of genes associated with IFN-γ, IL-12, IL-10, TLR4, TLR3, and TLR1.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The endothelin-1/TLR4/NF-κB/NLRP3 inflammasome axis in preeclampsia: a review of a pathological feed-forward loop and therapeutic frontier.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The designed MEV construct was evaluated through structural modelling, molecular docking with TLR4 receptor, immune simulation, population coverage analysis, codon optimization and in silico cloning.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “We further identified 201 common upregulated hub genes (including MMP9, CDH1, HSP90AB1, SOX2, CDKN2A, SPP1, EZH2) and 224 common downregulated hub genes (such as IL6, TNF, IL1B, JUN, CCL2, TLR4, FOS, PTGS2).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Expressions of toll-like receptor-4 (TLR4), pro-inflammatory interleukin 1 beta (IL-1β), interleukin 6 (IL-6), anti-inflammatory interleukins (IL-4, IL-13), apoptotic markers (bcl-2, bax) and microRNA-155b were measured by real-time PCR.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Genome-wide association studies have identified SNPs in HSP70A1A, HSPA4, TLR4, and PRLR as thermotolerance candidates compatible with sustained milk production.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Subsequently, the VC2 were docked to the toll-like receptors (TLR2, TLR3, and TLR4) and showed high binding affinities of -14.2 to -23.1kcal/mol, along with H-bonds (9 to 20).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Protein-protein docking computationally predicted favorable binding interactions between the vaccine construct and human TLR2 and TLR4 receptors, with ClusPro docking scores of -1489.2 and -1198.1, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Furthermore, the protein-protein molecular docking was conducted to define probable binding poses on the multi-epitope vaccine against the Toll-like receptor (TLR4) protein.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Hepatoprotection by Garlic Essential Oil Nanoemulsion Through Nrf2-Mediated Antioxidant Response and Inhibition of TLR4/NF-κB/NLRP3 Axis in High-Fat Diet-Fed Rats.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Potassium sorbate instigates sub-chronic cardiotoxicity via dysregulating TLR4/MyD88 and NF-κB pathway: A biochemical, radiological, histological, and computational validation.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The collected samples were then analyzed for gene expression and protein levels of mTOR, STAT3, TGF-β, β-catenin, NFκB, TNF-α, TLR4, and NLRP3.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking revealed strong binding with TLR4 (-9.7 kcal/mol) and TLR9 (-9.4 kcal/mol), and 200 ns molecular dynamics simulations confirmed stable RMSD trajectories, low RMSF at binding residues (<4 Å), persistent hydrogen bonding, compact radius of gyration (38-42 Å for TLR4; ~20 Å for TLR9), favorable total energy (-1400 to -1500 kcal/mol for TLR4; -650 to -720 kcal/mol for TLR9), and stable SASA (~52,000-54,000 Å2).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking revealed favourable binding affinity to TLR4 with a binding energy of - 1067.1, while molecular dynamics simulations showed structural stability, with an average RMSD of 0.40 nm and limited fluctuations.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking revealed strong interactions with TLR4 and TLR8, particularly MEV-TLR8, and molecular dynamics simulations supported the overall stability of the complex.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking against TLR3, TLR4, and TLR8 identified two top-performing candidates.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular analyses included the measurement of myeloid differentiation primary response gene 88 (MYD88), toll-like receptor 4 (TLR4), nuclear factor κB (NF-κB), interleukin (IL)-1β, IL-18, thioredoxin-interacting protein (TXNIP), NOD-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein (ASC), caspase-1, B-cell lymphoma-2 (BCL-2), BAX and caspase-3 expression.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Homopterocarpin alleviates methoxychlor-induced hepatotoxicity via modulating thioredoxin/peroxiredoxin and TLR4/MyD88 pathway: A comprehensive biochemical, histopathological, and computational analysis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Anti-inflammatory effect of pirfenidone compared to dexamethasone in ulcerative colitis model induced by acetic acid in rats: involvement of miR-146a and TLR4/NF-κB signaling.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Mechanistic insights into the hepatoprotective role of rabeprazole against cyclophosphamide-induced hepatotoxicity via AMPK/SIRT1 activation and suppression of TLR4/NF-κB and MAPK pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “In this study, we have performed population coverage analysis and molecular dynamic simulation studies which predicted that dvac could offer protection to 98.5% of world population against dengue and forms stable interactions with TLR3/TLR4 receptors, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking revealed various interactions between the vaccine construct C5 and the innate immune receptors TLR4/TLR5.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Mechanistically, MIE did not exert broad TLR inhibition but instead acted as a precise immunological rheostat, dampening responses to murine TLR2, TLR4, and TLR6 agonists.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Nephroprotective Potential of Tectorigenin Against Thiamethoxam Instigated Renal Toxicity Via Regulating HMGB1/RAGE, TLR4/MyD88, and NF-κB Pathway in Sprague Dawley Rats: An In-Vivo and In-Silico Investigation.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Intratracheal Si instillation resulted in considerable pulmonary injury, characterized by increased hydroxyproline, oxidative stress (elevated MDA along with reduced GSH, SOD, and CAT), and the activation of inflammatory (TLR4/NF-κB/NLRP3/IL-1β/IL-6) and fibrogenic (TGF-β/Smad) responses.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Potential relationships between circulating gene expression of ACE2, TLR4, and IL-17 and disease severity and outcome of hospitalized patients with COVID-19.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The construct was evaluated through structural modeling, molecular docking with TLR4, molecular dynamics simulation, immune simulation, and in silico cloning into the pET-28a(+) vector.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Physicochemical and docking analysis identified constructs V1 and V5 as having strong binding affinities to Toll-like receptors TLR4 and TLR2, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “To assess immune receptor engagement, molecular docking was conducted with TLR4 and TLR5, followed by 200 ns molecular dynamics simulations.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The vaccine construct and human Toll-like receptor 4 (TLR4) have shown considerable contact, according to molecular docking experiments, with a binding energy of - 1391.4 kcal/mol.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking with the TLR4 receptor demonstrated strong interactions, and molecular dynamics (MD) simulations, dynamic cross-correlation matrix (DCCM) analysis, binding free energy calculations, and principal component analysis (PCA) confirmed stable binding between the vaccine prototypes and TLR4.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The vaccine binds to and interacts with MHC molecules and TLR4 using molecular dynamics simulations and docking studies.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Activation of microglia through Toll-like receptor 4 (TLR4) signaling contributes to neuronal dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The molecular docking analysis and molecular dynamic simulation studies revealed robust and stable binding interaction between the H. parainfluenzae vaccine and the TLR4 immune receptor.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Apigenin promotes remodeling of peripheral and skeletal adipocytes in response to β3-AR and TLR4 activation.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “These proteins act as damage-associated molecular patterns (DAMPs), activating immune pathways via receptors like TLR4 and RAGE, thereby driving inflammation and immune cell recruitment.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking studies were conducted to validate the interactions between the vaccine construct and the human toll-like receptor (TLR4).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking studies indicate that our vaccine construct exhibits a strong binding affinity with the TLR4 receptor.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The molecular docking results of the vaccine with TLR4 showed the lowest energy of -1401.8 kcal/mol with the presence of 11 hydrogen bonds.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking demonstrated binding energies of -305.76 kcal/mol (TLR4), -254.28 kcal/mol (MHC-I), and - 270.85 kcal/mol (MHC-II), confirming stable interactions of the vaccine with TLR4 and MHC class I and II molecules.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Protein-protein interaction (PPI) network analysis highlighted key genes like EGFR, PTGS2, and TLR4 as central nodes in diabetes-related pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Correction: Role of TLR4 Asp299Gly and Thr399Ile Gene Polymorphisms as a Risk Factor in Human Cytomegalovirus Positive Pregnant Women.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “In addition, malathion increased TNF‑α, NF‑κB, Toll‑like receptor (TLR) 2 and TLR4 expression, and malathion toxicity induced severe hepatorenal damage, including vascular congestion, inflammatory infiltration and tubular degeneration.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Chrysophanol Attenuates Cognitive Impairment, Neuroinflammation, and Oxidative Stress by TLR4/ NFκB-Nrf2/HO-1 Signaling in Ethanol-Induced Neurodegeneration.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The analyses revealed that Naringenin can inhibit cell proliferation and oncogenesis through different molecular mechanisms and signaling pathways like apoptosis induction, cell cycle arrest, and modulation of P13K/AKT/mTOR, TGF-β1/Smad3, NF-κB, TLR4, and MAPK pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The impact of Linalool-ZOP at dosages of 20 mg/kg and 40 mg/kg, both individually and in conjunction with metronidazole (MTZ, 7.5 mg/kg) on the number and viability of Giardia cysts, the serum level of electrolytes of sodium (Na+) and potassium (K+), as well as the NF-kB signaling-related genes ((Tumor Necrosis Factor-alpha (TNF-a), Interleukin-1 (IL-1), IL-10, Nuclear Factor kappa B p65 (NF-kB p65), and Toll-like Receptor 4 (TLR4)) were assessed.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Additionally, mRNA expression of SGLT, TLR4, and NF-kB was significantly reduced in CA-treated T2DM group.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The constructed vaccine's physiochemical and structural features (secondary and tertiary), with structural stability (confirmed by molecular docking followed by dynamic simulation with TLRs (TLR4 & TLR2) and MHCs), were determined.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Role of TLR4 Asp299Gly and Thr399Ile Gene Polymorphisms as a Risk Factor in Human Cytomegalovirus Positive Pregnant Women.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Various parameters were used to validate the designed MEVC which involved prediction of physiochemical properties, modeling and validation of the 3D structure, interaction with the immune receptors such as TLR2 (Toll-like receptor) and TLR4.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking studies verified strong interactions with immune receptors, particularly toll-like receptor (TLR)2, TLR3, TLR4, TLR8, and human leukocyte antigen molecules, indicating robust immune stimulation potential.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “In vitro, stimulation of human bronchial fibroblasts with S100A8/S100A9 upregulated fibrotic markers (COL1A1 and α-SMA), which were reduced by inhibitors of TLR4 and RAGE receptors, as well as by paquinimod.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking analysis demonstrated a robust interaction between the vaccine construct and the human Toll-like receptor 4 (TLR4), with a binding energy of -1277.0 kcal/mol.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The model vaccine structures were analyzed via rigorous criteria of physiochemical properties, antigenicity, and molecular docking with HLA and TLR4 immune receptors to ensure their efficacy and safety.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Ameliorative Effect of N-Acetylcysteine Against 5-Fluorouracil-Induced Cardiotoxicity via Targeting TLR4/NF-κB and Nrf2/HO-1 Pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Effects of Fisetin and Nicorandil on adjuvant-induced rheumatoid arthritis in rats: Emerging role of TLR4/NF-κB-induced Pyroptosis, Nrf-2/HO-1, and OPG/RANKL pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Protective effects of Kaempferol on hepatic apoptosis via miR-26a-5p enhancement and regulation of TLR4/NF-κB and PKCδ in a rat model of nonalcoholic fatty liver.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Prevention of fenitrothion induced hepatic toxicity by saponarin via modulating TLR4/MYD88, JAK1/STAT3 and NF-κB signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Pharmacotherapeutic potential of artemetin against amiodarone instigated sub-chronic hepatotoxicity via modulating TLR4/HMGB1/RAGE and NF-κB signaling pathways: An in-vivo and in-silico approach.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “This effect was mediated through the downregulation of pro-inflammatory and stress-related genes, including IL-6, COX-2, iNOS, TLR2, TLR4, NLRP3, CHOP, JNK, XBP1, and ATF6.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Furthermore, treatment with L. rhamnosus, Thy and their combination improved abnormalities in the tested biomarkers and modulated associated pathways, including significant upregulation of BDNF, TrkB, CREB, Nrf2, and HO-1 content and downregulation of TLR4/NF-κB-mediated neuroinflammation, leading to substantial improvements in ASD symptoms.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Retraction notice to "Ameliorative effects of vanillin against pentylenetetrazole-induced epilepsy and associated memory loss in mice: The role of Nrf2/HO-1/NQO1 and HMGB1/RAGE/TLR4/NFκB pathways" [Int.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Indole-3-acetic acid and chenodeoxycholic acid attenuate TLR4/NF-κB signaling and endoplasmic reticulum stress in valproic acid-induced neurotoxicity.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Treatment resulted in substantial reductions in key inflammatory markers, including HMGB1, RAGE, TLR4 expression, NFκB activity, pro-inflammatory cytokines (TNF-α and IL-6), and apoptosis marker caspase-3.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Acetic acid induced-ulcerative colitis is repressed by morin via modulation of CD3/CD4 mucosal immunity and TLR4/NF-κB/ERK1/2/IL-6 signalling in rats.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “RESULTS: Network Pharmacology suggested Toll-like receptors 4 (TLR4) and interleukin-1beta (IL-1β) as potential targets of Gal EO components in Genta-induced renal toxicity.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Pharmacotherapeutic role of astringin against chromium induced nephrotoxicity via modulating TLR4/MyD88, HMGB1/RAGE and NF-κB pathway: A biochemical and pharmacokinetic approach.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “A Quinoxaline Derivative as a New Therapeutic Agent for Sepsis through Suppression of TLR4 Signaling Pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Nephroprotective potential of robinin to counteract aldicarb induced renal dysfunction via modulating TLR4/MyD88, HMGB1/RAGE, NF-κB pathway: A biochemical and pharmacodynamic approach.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Chitosan-Based Intelligent Microneedles for Delivery of Amphotericin B Loaded Oleosomes: Antifungal Ocular Patch Targeting for Effective Against Fungal Keratitis Using Rabbit Model via TLR4/NLRP3 Pathway.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Naftidrofuryl mitigates LPS-induced pulmonary injury through macrophage polarization and NLRP3/TLR4 regulation, an in vitro and in vivo perspective.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, and TLR9 were significantly downregulated in both genotypes as compared to controls, with genotype D showing greater downregulation of TLR1, TLR5, TLR6, and TLR7 among HBV-positive patients.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The key host genes involved in immune responses (e.g., BoLA-DRB3 and TLR4), oxidative stress defense (SOD2 and GPX1), drug metabolism (ABCB1 and CYP3A4), and ectoparasite resistance (MC1R and MHC) have been identified as contributors to resistance phenotypes.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Based on immune simulation study, the vaccine exhibited adequate immune-reactivity and favorable encounters with toll-type receptors (TLR4, TLR8, HLA, etc ACE), Among them the SARS-COV-2-C2 showed best binding affinity of which all receptors.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Docking was conducted to check the binding energy of the designed peptide vaccine with the human immune receptors, namely TLR2 and TLR4.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Petunidin attenuates vinclozolin instigated testicular toxicity in albino rats via regulating TLR4/MyD88/TRAF6 and Nrf-2/Keap-1 pathway: A pharmacodynamic and molecular simulation approach.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Moreover, the abilityof the vaccine to bind TLR4, a core innate immune receptor, was confirmed.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Regarding the TLR4 expression, it was clearly up-regulated in the E. coli group in comparison to other groups, while CD14 gene decreased clearly in all treated groups compared to the positive group.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The mRNA abundance of the proinflammatory genes tumor necrosis factor, toll-like receptor 2 (TLR2), and TLR4 in the ruminal epithelium peaked (P < 0.05) at FRP and remained higher at POST.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “TLR4, IL-8, IL-17, NFKB, SLCA11A1, NCF4, Keap1, HMOX1, OXSR1, ST1P1, and SERP1 were manifestly expressed at much higher levels in the buffaloes with endometritis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking studies were performed to evaluate the receptor-binding ability of the NS1 and dNS1 with TLR4.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “OBJECTIVES: We aimed to explore the potential therapeutic effects of Arctiin on rats with AD by evaluating the expression of TLR4, NLRP3, STAT3, TGF-β, cyclin D1, and CDK2.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Protein-protein docking and MD simulation found that vaccines 3 was more stable and had a higher binding affinity for TLR2 and TLR4 immune receptors.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Gene expression levels of the TLR4/MyD88/NFκB pathway, along with Bax and Bcl-2, were evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Deciphering the therapeutic potential of trimetazidine in rheumatoid arthritis via targeting mi-RNA128a, TLR4 signaling pathway, and adenosine-induced FADD-microvesicular shedding: In vivo and in silico study.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Inflammatory signaling, including PCSK9, HMGB1/RAGE/TLR4/MYD88/NF-κB, NLRP3/caspase-1 and Fractalkine/CX3CR1 are considered major forerunners in this link.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Subsequently, the vaccine structure was docked with the TLR4/MD2 complex and six different HLA allele receptors using the HADDOCK server.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Pinocembrin's protective effect against acute pancreatitis in a rat model: The correlation between TLR4/NF-κB/NLRP3 and miR-34a-5p/SIRT1/Nrf2/HO-1 pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Top hub genes identified were TLR4, MMP9, MAPK14, AKT1, VEGFA and HSP90AA1 with their respective associates.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Moreover, qPCR and western blot results indicated that TLR2, TLR4, proinflammatory mediators, and apoptosis-mediated genes upregulated except Bcl-2, which is antiapoptotic, and there were downregulations of oxidative stress-related genes in the infected uterine tissue.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The vaccine's binding stability with Toll-like receptor 2 (TLR2) and TLR4 was confirmed using molecular docking and molecular dynamics (MD) simulation.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “SNP Analysis of TLR4 Promoter and Its Transcriptional Factor Binding Profile in Relevance to Bovine Subclinical Mastitis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “This study investigated the effects of nanomethionine (nano-meth) on performance, antioxidants, and gene expression of HSP70, HSP90 and Heat Shock factor-1 (HSF-1) from the liver, and TLR4 from the jejunum, of broiler chickens reared under normal temperatures or under heat stress.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Association of TLR4 gene rs4986790 and rs4986791 polymorphisms with asthma susceptibility: meta-analysis and trial sequential analysis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Chrysophanol attenuates cognitive impairment, neuroinflammation, and oxidative stress by TLR4/NFκB-Nrf2/HO-1 and BDNF/VEGF signaling in stress-intensified PTZ induced epilepsy in mice.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Comparative effect of atorvastatin and risperidone on modulation of TLR4/NF-κB/NOX-2 in a rat model of valproic acid-induced autism.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Ameliorative effects of vanillin against pentylenetetrazole-induced epilepsy and associated memory loss in mice: The role of Nrf2/HO-1/NQO1 and HMGB1/RAGE/TLR4/NFκB pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Rutin is a natural flavonoid with many pharmacological activities and its role in acetic acid-induced ulcerative colitis through the high mobility group B1 (HMGB1)/ toll-like receptor-4 (TLR4)/ myeloid differentiation primary response protein 88 (MYD88)/ nuclear factor-kB (NF-kB) signaling pathway needs to be explored.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Neuroprotective effects of all-trans-retinoic acid are mediated via downregulation of TLR4/NF-κB signaling in a rat model of middle cerebral artery occlusion.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “We performed immunohistochemical analyses to evaluate the expression of Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) p65 at the ulcer sites.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular dynamics simulation for vaccine construct 2 with TLR4 denoted high binding affinity and stability of the construct with the receptor which might foretell favorable in vivo interaction and immune responses.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Rosuvastatin and diosmetin inhibited the HSP70/TLR4 /NF-κB p65/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney injury induced by cisplatin.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “CUR significantly down-regulated mRNA levels expression of IL-1β, TNF-α, and TLR4 and up-regulated IL-10 mRNA expression levels in spleens of birds when compared to those exposed to IMI-and non-treated.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Furthermore, strong interactions were demonstrated with toll-like receptors 2 (TLR2) and 4 (TLR4) according to the molecular dynamic simulation studies.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Docking simulation results revealed that this peptide could bind to the LPS binding site of MD-2, which may prevent LPS from entering the MD-2 binding pocket, and trigger TLR4 signaling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Also, the CC genotype was linked to an increase in the mRNA expression of TLR4 (P = 0.03) and the inflammatory cytokines IL-1β and TNF-α (P = 0.01 and 0.04, respectively) and had no effect on the NF-kB level (P = 0.3).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 4 (TLR4) gene have been documented in type 2 diabetes mellitus (T2DM) and other diseases in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The molecular docking and molecular dynamic (MD) simulation analyses indicated that the vaccine design V1 demonstrated robust and stable molecular interactions with toll-like receptor 4 (TLR4).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-κB/TLR4 signals.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Sufficient evidence currently exists demonstrating the crucial role of inflammation, characterized by the enhanced activation of Toll-like receptor 4 (TLR4) and the COX-2/PGE2 pathway, in the migration and proliferation of breast cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Nucleotide sequence variations between healthy and endometritis-affected cows were revealed using PCR-DNA sequencing for immune (TLR4, TLR7, TNF-α, IL10, NCF4, and LITAF), antioxidant (ATOX1, GST, and OXSR1), and erythritol-related (TKT, RPIA, and AMPD1) genes.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The vaccine was produced with 31 epitopes, a TLR4 agonist termed RpfE that acts as an adjuvant, secretion boosters, subcellular trafficking structures, and linkers.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Toll-Like Receptor 4 (TLR4) and its close association with p-38-Mitogen-Activated Protein Kinase (p-38 MAPK) and nuclear factor kappa B (NF-κB) has important regulatory roles in inflammation and developing UC.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Diacerein modulates TLR4/ NF-κB/IL-1β and TRPC1/CHOP signalling pathways in gentamicin-induced parotid toxicity in rats.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The constructs' binding affinity was confirmed through docking with TLR4/MD2 complex and showed significant binding free energy (-96.67 kcal mol-1) with positive binding affinity.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “DNA sequencing of PRLR (304-bp), LTF (904-bp), TLR2 (420-bp), TLR4 (335-bp), CLA-DRB3.2 (285-bp), SOD3 (735-bp), CAT (1526-bp), GPX4 (782-bp), and GST (690-bp) revealed SNPs associated with reproductive disorders tolerance/susceptibility in investigated does.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The tertiary structure of the constructed vaccine was predicted and refined, and its interaction with the Toll-like receptor 4 (TLR4) was investigated through molecular docking and dynamics simulation.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The tertiary structure of the chimeric vaccine construct was modeled via I-TASSER, and its interaction with Toll-like receptor 4 (TLR4) was evaluated using molecular docking and molecular dynamics simulation.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “TLR4 activation in turn caused c-JUN-dependent and STAT3-dependent translocations of MYC loci to suppress transactivation of CD95/FAS.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “NIFU restored the balance between TAC and both of ROS and MDA and down-regulated the protein expression of TLR4, NF-kB, TXNIP, NLR-family pyrin domain containing 3 (NLRP3), caspase-1, IL-1β, and GSDMD-N terminal, with inhibition of the up-stream of NLRP3 and the down-stream DOX-induced pyroptosis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “BBR suppressed the HMGB1/TLR4/NF-κB pathway activation in MIRI.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Furthermore, indomethacin administration led to disturbed intestinal permeability, evidenced by the activation of the NLRP3 inflammasomes pathway and elevation of downstream biomarkers (TLR4, IL18, caspase 1).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Canagliflozin ameliorates ulcerative colitis via regulation of TLR4/MAPK/NF-κB and Nrf2/PPAR-γ/SIRT1 signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “These promising effects appear to be mediated by suppressing STAT3 as well as NF-κB, TLR4, and β-catenin expressions and effectively decreasing downstream cytokines TNF-α, IL-1β, and IL-6.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Correction to: Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF‑κB‑p65/iNOS and SIRT1/PPARγ signaling pathways in rats.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Animals that experienced renal I/R exhibited elevated lipid peroxidation (MDA); declined SOD, CAT, and GPx activity; declined GSH content; augmented TLR4/NFκB gene expression; and subsequent enhancement of inflammatory mediators (TNF-α, IFN-γ, IL-1β, and IL-6).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The present study aimed to use a whole milk stimulation assay for investigating the modulatory effect of selected Toll-like receptor (TLR) ligands on the phenotype and function of milk immune cells. (2) Methods-camel milk samples (n = 7) were stimulated in vitro with the TLR4 ligand LPS or the TLR2/1 ligand Pam3CSK4, and separated milk cells were evaluated for stimulation-induced shape change, the expression of cell surface markers, phagocytosis, apoptosis, ROS production, and NETosis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The aim of the present study was to investigate the role of the toll-Like receptors (TLR2 and TLR4) signaling pathway and its downstream effector chemokine genes in the pathogenesis of chronic dacryocystitis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Increasing evidence reports that the PCSK9 axis mediates IA through different pathways, such as LDLR, LOX1, NF-kB, and TLR4.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Investigation of TLR2 and TLR4 Polymorphisms and Sepsis Susceptibility: Computational and Experimental Approaches.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Whereas, other gene mutations in ABCB1, ABCC1, CASR, IL-17F, NOTCH1, NOTCH4, PRNCR1, TDG, TLR2, TLR4, TLR-9, TSLP, TSLPR and TNF-α genes showed irrelevant correlation with CRC risk in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Further, TLR4 activation by its ligand, lipopolysaccharide (LPS) further upregulates inflammatory potential of B cells from ASD group by increasing IL-6 expression, whereas LPS has no significant effect on IL-10 expression in ASD group.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways in rats.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “We measured the gene expression for Toll-Like Receptors (TLR2 and TLR4), ACE2, and NRP-1 in the blood samples using quantitative real-time PCR (qRT-PCR).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Anethole reduced gene and protein expression levels of HMGB1, TLR2, TLR4, MYD88, and NFκB.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Molecular docking and molecular dynamics simulation indicated a stable and energetically favourable interaction between the constructed antigen and Toll-like receptors (TLR2, TLR3, and TLR4).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Macrophages were examined for markers of maturation (CD14, CD68), activation (HLA-DR, CD86, IL15R), scavenger receptor (CD36), toll-like receptor (TLR4), M2 marker (CD206), immune checkpoint (PD-L1), and intracellular chemokine expression (IP-10).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “In this study, we compared the relative gene expression levels of the Akt1s1, FGF, GH, IGF1, MSTN, TLR2, TLR4 and TLR5 genes in blood in groups of common carps (Cyprinus carpio), which belonged to different growth types and phenotypes.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Allicin inhibits neuroinflammation by suppressing the ROS production, inhibition of TLR4/MyD88/NF-κB, P38 and JNK pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Importantly, the molecular docking analysis and molecular dynamics simulations revealed that the constructed vaccine possessed a high affinity for toll-like receptor 4 (TLR4).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Twelve SNPs were investigated as follows: rs16944 (IL-1B), rs1143634 (IL-1B), rs1800587 (IL-1A), rs2069762 (IL-2), rs3212227 (IL-12B), rs2234650 (IL-1R1), rs315952 (IL-1RN), rs3804099 (TLR2), rs4986790 (TLR4), rs4986791 (TLR4), rs1800629 (TNF) and rs361525 (TNF).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “In vivo and in vitro studies of Danzhi Jiangtang capsules against diabetic cardiomyopathy via TLR4/MyD88/NF-κB signaling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Nimbolide ameliorates the streptozotocin-induced diabetic retinopathy in rats through the inhibition of TLR4/NF-κB signaling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “CONCLUSIONS: GL significantly improved renal function indices through dose-dependent kidney function restoration, oxidative stress reduction, down-regulation of gene expression of KIM-1 and TLR4/NFκB signalling pathway blockage with subsequent alleviation of renal inflammation and fibrosis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “The survival rate, liver function tests, tissue antioxidant enzymes, malondialdehyde (MDA), nuclear factor (erythroid derived 2)-like 2 (Nrf2), transforming growth factor beta 1 (TGF-β1), interleukin 1 alpha (IL-1α), and toll-like receptor 4 (TLR4) were measured.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Anti-inflammatory/anti-apoptotic impact of betulin attenuates experimentally induced ulcerative colitis: An insight into TLR4/NF-kB/caspase signalling modulation.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Renal tissue nerve growth factor-β (NGF-β), transforming growth factor beta 1 (TGF-β1), proinflammatory cytokines, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), toll-like receptor 4 (TLR4), nuclear factor kappa B (NF-κB) p65, signal transducer and activator of transcription 3 (STAT3), oxidative stress parameters, beclin-1 and c-Jun NH2-terminal kinase (JNK) activities were measured.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “An in silico vaccine was developed using carefully selected epitopes (11 CTL, 2 HTL & 10 LBL) and then docked with the MHC molecules (MHC I & MHC II) and human TLR4.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Polymorphisms in host genes such as the toll-like receptor 4 (TLR4) might affect the susceptibility and severity of infection and treatment success.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “RESULTS: The results showed a significant association between TLR4 SNPs (rs 4986790 and rs 4986791) and the presence of H. pylori infection, especially in chronic gastritis patient group.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “B cells play an important role in immune dysfunction where toll-like receptor 4 (TLR4) may contribute through oxidative inflammatory process.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Antiulcerogenic effect of melittin via mitigating TLR4/TRAF6 mediated NF-κB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “BACKGROUND: Herbal melanin (HM) is a dark pigment extracted from the seed coat of Nigella sativa L. and known to exert biological effects via toll-like receptor 4 (TLR4).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “NOD2 is a member of the NOD-like receptor (NLR) family of pattern recognition receptors (PRRs), while MD-2 is a co-receptor for Toll-like receptor 4 (TLR4), which comprises another group of PRRs.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Activation of toll-like receptor 4 (TLR4) through TLR4 agonist, lipopolysaccharide (LPS), stimulation initiate a signaling cascade whereby the TLR4-LPS interaction has been found to result in physiological and behavioural changes including retardation of motor activity in the mouse model.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Morphometric assessment of stria vascularis thickness, hair cells and spiral ganglia neuronal number and optical density of TLR4 expression were done.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Pathway network analysis has shown the RA-specific disturbances in the functional connectivity between seed genes (RIPK1, ATG7, TLR4, TNFRSF1A, KPNA1, CFLAR, SNW1, FOSB, PARVA, CX3CL1, and TRPC6) and NKPF members (RELA, RELB, NFKB2, and REL).” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Here, we explored whether resveratrol treatment decreases neuroimmune dysregulation mediated through toll-like receptor (TLR4) and nuclear factor-κB (NF-κB) signaling pathway in BTBR mice.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Toll-like receptor 4 (TLR4) plays an important role in modulating innate immunity.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “HG and AGE stimulated FOXO1 nuclear localization, which was reversed by insulin and inhibitors of TLR4, histone deacetylase, nitric oxide, and reactive oxygen species.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Vildagliptin Attenuates Hepatic Ischemia/Reperfusion Injury via the TLR4/NF-κB Signaling Pathway.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Here, we investigated the effect of pattern recognition receptors (PRR) activation in macrophages, especially the toll-like receptor 4 (TLR4) and Nod-like receptor 3 (NLRP3), on white adipocyte browning.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Treatment of BTBR mice with SCH increased the percentage of splenic CD14+TLR2+ cells, CD14+TLR3+ cells, CD14+TLR4+ cells, and decreased the percentage of CD14+IL-27+ cells, as compared to the untreated BTBR mice.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Prothymosin-α Variants Elicit Anti-HIV-1 Response via TLR4 Dependent and Independent Pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “In this study, we investigated the contribution of SNPs in interleukin (IL)-1B1 (rs16944), IL1A (rs1800587), IL1B (rs1143634), toll-like receptor (TLR)-2 (rs3804099), TLR4 (rs4986790), TLR4 (rs4986791), IL1R (rs2234650), tumor necrosis factor (TNF)-α (rs1800629), TNF (rs361525), and IL1RN (rs315952) towards the development of HO in Saudi patients and compared to healthy controls.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Our aim was to evaluate the association between the expression and the polymorphism of TLR4/NF-κB pathways and colon cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “No SNPs single nucleotide polymorphisms (SNPs) were found in the TLR4 gene at the sites Asp299Gly and Thr399Ile.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Cardiomyocyte-fibroblast interaction contributes to diabetic cardiomyopathy in mice: Role of HMGB1/TLR4/IL-33 axis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “A recent study reported that TLR4 gene polymorphisms are good prognostic predictors and are associated with protection from liver fibrosis among Caucasians.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Polymorphisms in the CARD15/NOD2 gene, in addition to functional variants of the toll-like receptor-4 (TLR4) and CD14 genes, have been associated with the development of Crohn's disease.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Both the TLR3- and the TRIF-dependent TLR4 signaling pathways were abolished.” | 0.98 | hgnc_dict_v1 |