Parkinson disease
SaudiVarKB evidence summary derived from retained literature mentions.
232Phenotype mentions
100Publications
50Associated gene records
33Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| LRRK2 | HGNC:18618 | 12 | 12 |
| SNCA | HGNC:11138 | 11 | 11 |
| PINK1 | HGNC:14581 | 9 | 9 |
| APOE | HGNC:613 | 5 | 5 |
| SIRT1 | HGNC:14929 | 3 | 3 |
| ATP13A2 | HGNC:30213 | 3 | 3 |
| GBA1 | HGNC:4177 | 3 | 3 |
| PRKN | HGNC:8607 | 3 | 3 |
| PARK7 | HGNC:16369 | 3 | 3 |
| DNAJC6 | HGNC:15469 | 3 | 3 |
| SOD1 | HGNC:11179 | 2 | 2 |
| DRD2 | HGNC:3023 | 2 | 2 |
| PLA2G6 | HGNC:9039 | 2 | 2 |
| VPS35 | HGNC:13487 | 2 | 2 |
| BAX | HGNC:959 | 2 | 2 |
| FOXO1 | HGNC:3819 | 2 | 2 |
| TH | HGNC:11782 | 2 | 2 |
| PSMF1 | HGNC:9571 | 2 | 2 |
| GAPDH | HGNC:4141 | 2 | 2 |
| SIRT3 | HGNC:14931 | 2 | 2 |
| PPARGC1A | HGNC:9237 | 2 | 2 |
| GPNMB | HGNC:4462 | 2 | 2 |
| PARP1 | HGNC:270 | 1 | 1 |
| ULK1 | HGNC:12558 | 1 | 1 |
| TNF | HGNC:11892 | 1 | 1 |
| NLRP3 | HGNC:16400 | 1 | 1 |
| BDNF | HGNC:1033 | 1 | 1 |
| MAPT | HGNC:6893 | 1 | 1 |
| CYP2D6 | HGNC:2625 | 1 | 1 |
| PTEN | HGNC:9588 | 1 | 1 |
| GSK3B | HGNC:4617 | 1 | 1 |
| GPX4 | HGNC:4556 | 1 | 1 |
| BRCA1 | HGNC:1100 | 1 | 1 |
| SPG7 | HGNC:11237 | 1 | 1 |
| AKT1 | HGNC:391 | 1 | 1 |
| HTT | HGNC:4851 | 1 | 1 |
| TP53 | HGNC:11998 | 1 | 1 |
| FOXC1 | HGNC:3800 | 1 | 1 |
| BSN | HGNC:1117 | 1 | 1 |
| SNAP91 | HGNC:14986 | 1 | 1 |
| AGA | HGNC:318 | 1 | 1 |
| CCND1 | HGNC:1582 | 1 | 1 |
| SCN1A | HGNC:10585 | 1 | 1 |
| ESR1 | HGNC:3467 | 1 | 1 |
| TLR4 | HGNC:11850 | 1 | 1 |
| RELA | HGNC:9955 | 1 | 1 |
| VPS41 | HGNC:12713 | 1 | 1 |
| VPS11 | HGNC:14583 | 1 | 1 |
| VPS16 | HGNC:14584 | 1 | 1 |
| VPS18 | HGNC:15972 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| rs3115534 | rs3115534 | 1 | 1 |
| c.2070_2072del | c.2070_2072del | 1 | 1 |
| c.956C>T | c.956C>T | 1 | 1 |
| p.Thr319Met | p.Thr319Met | 1 | 1 |
| rs4680 | rs4680 | 1 | 1 |
| rs9652490 | rs9652490 | 1 | 1 |
| rs11856808 | rs11856808 | 1 | 1 |
| c.1498C>T | c.1498C>T | 1 | 1 |
| p.Arg500Trp | p.Arg500Trp | 1 | 1 |
| V82A | V82A | 1 | 1 |
| K80E | K80E | 1 | 1 |
| E46K | E46K | 1 | 1 |
| p.A18G | p.A18G | 1 | 1 |
| p.V82A | p.V82A | 1 | 1 |
| p.K80E | p.K80E | 1 | 1 |
| p.E46K | p.E46K | 1 | 1 |
| E326K | E326K | 1 | 1 |
| T369M | T369M | 1 | 1 |
| N370S | N370S | 1 | 1 |
| L444P | L444P | 1 | 1 |
| c.1366C>T | c.1366C>T | 1 | 1 |
| p.Gln456* | p.Gln456* | 1 | 1 |
| c.1597dup | c.1597dup | 1 | 1 |
| T313M | T313M | 1 | 1 |
| G2019S | G2019S | 1 | 1 |
| L166P | L166P | 1 | 1 |
| G2019S | G2019S | 1 | 1 |
| G1135T | G1135T | 1 | 1 |
| p.G379W | p.G379W | 1 | 1 |
| rs7684318 | rs7684318 | 1 | 1 |
| c.3706C>T | c.3706C>T | 1 | 1 |
| rs199347 | rs199347 | 1 | 1 |
| E326K | E326K | 1 | 1 |
Associated population records
Co-mentioned in the same publications| Population | Identifier / context | Articles | Mentions |
|---|---|---|---|
| Population record | Cohort 19 | 3 | 3 |
| Population record | Cohort 2 | 3 | 3 |
| Saudi Arabia | — | 2 | 2 |
| Population record | — | 1 | 1 |
| Population record | Cohort 24 | 1 | 1 |
| Population record | Cohort 11 | 1 | 1 |
| Population record | Cohort 75 | 1 | 1 |
| Saudi Arabia | Cohort 2 | 1 | 1 |
| Population record | Cohort 274 | 1 | 1 |
| Population record | Cohort 6 | 1 | 1 |
| Population record | Cohort 25 | 1 | 1 |
| Population record | Cohort 60 | 1 | 1 |
| Population record | Cohort 1,344 | 1 | 1 |
| Population record | Cohort 332 | 1 | 1 |
| Population record | Cohort 918 | 1 | 1 |
| Population record | Cohort 1,322 | 1 | 1 |
| Hail | — | 1 | 1 |
| Saudi Arabia | Cohort 5 | 1 | 1 |
| Population record | Cohort 14 | 1 | 1 |
| Saudi Arabia · Eastern Province | — | 1 | 1 |
| Population record | Cohort 567 | 1 | 1 |
| Population record | Cohort 585 | 1 | 1 |
| Population record | Cohort 203 | 1 | 1 |
| Saudi Arabia | Cohort 50 | 1 | 1 |
| Saudi Arabia · Riyadh | Cohort 2,023 | 1 | 1 |
| Population record | Cohort 265 | 1 | 1 |
| Population record | Cohort 225 | 1 | 1 |
| Saudi Arabia · Jeddah | Cohort 9 | 1 | 1 |
| Population record | Cohort 438 | 1 | 1 |
| Saudi Arabia | Cohort 380 | 1 | 1 |
| Saudi Arabia · Riyadh | Cohort 143 | 1 | 1 |
| Population record | Cohort 370 | 1 | 1 |
| Population record | Cohort 829 | 1 | 1 |
Supporting publications
100 records- 2026Neuronal plasticity and its role in Alzheimer's disease and Parkinson's disease.Neural regeneration research1 mentions
- 2026The gut-brain axis: role of gut microbiota in neurological disease pathogenesis and pharmacotherapeutics.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Practices, Resources and Challenges in Parkinson's Disease Management in Asia: Movement Disorders in Asia Study Group Report.Movement disorders clinical practice1 mentions
- 2026Unraveling the metabolic potential of Moringa oleifera derived metabolites in combating Parkinson's and Alzheimer's disease.Bioorganic chemistry1 mentions
- 2026Adenosine A₂A receptor as a dual-acting molecular switch: Glial morphological changes and neurovascular tissue remodeling in neuroinflammation and neurodegeneration.Tissue & cell1 mentions
- 2026Totarol-1 Derivative Improves Neuronal Disability in Lead-Induced In Vivo Zebrafish Model.Journal of biochemical and molecular toxicology1 mentions
- 2026TREM2 in neurodegeneration and diseases.Molecular psychiatry1 mentions
- 2026Astrocytic dysfunction in Parkinson's disease pathogenesis: focusing on alpha-synuclein.Inflammopharmacology1 mentions
- 2026Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from parkinsonism to perinatal lethality.Nature communications1 mentions
- 2026Targeting VDR-RXR heterodimerization in neurodegenerative diseases: a hypothetical framework for combined vitamin D3 and vitamin A therapy.Frontiers in neurology1 mentions
- 2026Machine learning to diagnose, classify and predict phenoconversion in isolated REM sleep behavior disorder.Sleep medicine reviews1 mentions
- 2026Multimodal Remote Digital Phenotyping for Detecting and Tracking Early Parkinsonian Change in LRRK2 Carriers.Research square1 mentions
- 2026Exosomal miRNA in cerebrospinal fluid as biomarkers for neurodegenerative disease.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Exosome-mediated gut-brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives-A narrative review.Animal models and experimental medicine1 mentions
- 2026Polymeric lysosome-targeting chimeras for extracellular α-synuclein degradation in Parkinson's disease.Acta neuropathologica communications1 mentions
- 2026Role of 5α-reductase inhibitors in Parkinson's disease: Gambling or not?The Journal of steroid biochemistry and molecular biology1 mentions
- 2026Resveratrol alleviates neurological disorders and motor dysfunction in 3-NP induced- Huntington's Disease in rats: Role of activating AMPK/SIRT1/ULK1 autophagy pathway.Neuropharmacology1 mentions
- 2026Loss of PINK1 causes age-dependent mitochondrial trafficking deficits in nigrostriatal dopaminergic neurons via aberrant p38 MAPK activation.NPJ Parkinson's disease1 mentions
- 2025Comprehensive mapping of mutations in TDP-43 and α-Synuclein that affect stability and binding.Journal of biomolecular structure & dynamics1 mentions
- 2025Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from early-onset Parkinson's disease to perinatal lethality and disrupt mitochondrial function.medRxiv : the preprint server for health sciences1 mentions
- 2025MicroRNAs Modulating Neuroinflammation in Parkinson's disease.Inflammation1 mentions
- 2025Integrating Blood Biomarkers and Marine Brown Algae-Derived Inhibitors in Parkinson's Disease: A Multi-scale Approach from Interactomics to Quantum Mechanics.Molecular biotechnology1 mentions
- 2025Decoding the Therapeutic Potential of Cannabis and Cannabinoids in Neurological Disorders.Current pharmaceutical design1 mentions
- 2025Critical evaluation of the current landscape of pharmacogenomics in Parkinson's disease - What is missing? A systematic review.Parkinsonism & related disorders1 mentions
- 2025CNV-Finder: Streamlining Copy Number Variation Discovery.bioRxiv : the preprint server for biology1 mentions
- 2025Analysis of key lncRNA related to Parkinson's disease based on gene co-expression weight networks.Neurosciences (Riyadh, Saudi Arabia)1 mentions
- 2025An Integrative Computational Approach for the Identification of C-Abl Kinase Inhibitors from Anti-Parkinson Plant-Derived Bioactive.Medicinal chemistry (Shariqah (United Arab Emirates))1 mentions
- 2025Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies.Food science & nutrition1 mentions
- 2025Parkinson's disease exacerbation following Levetiracetam administration: an unusual phenomenon.Oxford medical case reports1 mentions
- 2025Therapeutic potential of cannabinoids in neurological conditions: a systematic review of clinical trials.Frontiers in pharmacology1 mentions
- 2025Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review.Frontiers in pharmacology1 mentions
- 2025Dysregulation of serotonergic neurotransmission in Parkinson disease: A key duet.European journal of pharmacology1 mentions
- 2025α-Synuclein Iron-Responsive-Element RNA and Iron Regulatory Protein Affinity Is Specifically Reduced by Iron in Parkinson's Disease.Biomolecules1 mentions
- 2025PADG-Pred: Exploring Ensemble Approaches for Identifying Parkinson's Disease Associated Biomarkers Using Genomic Sequences Analysis.IET systems biology1 mentions
- 2025Clinical predictors of freezing of gait in patients with Parkinson's disease: A systematic review.Clinical neurology and neurosurgery1 mentions
- 2025Nano-healing: Exploring the Therapeutic Potentials of Nanomedicine for CNS Disorders.Current pharmaceutical design1 mentions
- 2025Molecular mechanisms and biomarkers in neurodegenerative disorders: a comprehensive review.Molecular biology reports1 mentions
- 2025Flavonoids and their role in oxidative stress, inflammation, and human diseases.Chemico-biological interactions1 mentions
- 2025Redox modulatory role of DJ-1 in Parkinson's disease.Biogerontology1 mentions
- 2025Corrigendum to "Dysregulation of serotonergic neurotransmission in Parkinson disease: A key duet" [Eur. J. Pharmacol. 995 (2025) 177419].European journal of pharmacology1 mentions
- 2025Fucoxanthinol Mitigates the Cytotoxic Effect of Chlorpyrifos and MPTP on the Dopaminergic Differentiation of SH-SY5Y Human Neuroblastoma Cells.Journal of molecular neuroscience : MN1 mentions
- 2025Effects of herbaceous bioflavonoid herbacetin on oxidative stress, and alpha-synuclein regulation, programmed cell death in a Parkinson illness.Archives of physiology and biochemistry1 mentions
- 2025The role of glutathione S-transferases in human disease pathogenesis and their current inhibitors.Genes & diseases1 mentions
- 2025Discovering Novel Biomarkers and Potential Therapeutic Targets of Amyotrophic Lateral Sclerosis Through Integrated Machine Learning and Gene Expression Profiling.Journal of molecular neuroscience : MN1 mentions
- 2025The role of interleukin (IL)-2 cytokine family in Parkinson's disease.Cytokine1 mentions
- 2025Physicochemical profiling and ranking of parkinson's disease drugs through QSPR and Fuzzy TOPSIS analysis.Scientific reports1 mentions
- 2025The Effect of Metformin on Astrocytes in Parkinson's Disease: Challenges and Opportunities.Molecular neurobiology1 mentions
- 2025LRP1 at the crossroads of Parkinson's and Alzheimer's: Divergent roles in α-synuclein and amyloid pathology.European journal of pharmacology1 mentions
- 2025Zebrafish-Based Parkinson's Disease Models: Unveiling Genetic Mechanisms and Therapeutic Pathways.CNS & neurological disorders drug targets1 mentions
- 2025Advances in alginate-based nanoformulations: Innovative and effective strategies for targeting and treating brain disorders.International journal of pharmaceutics1 mentions
- 2025Unlocking the potential: advancements and applications of gene therapy in severe disorders.Annals of medicine1 mentions
- 2025Possible Mitigating Effect of Nobiletin on Rotenone-Induced Parkinsonism in Male Albino Rat Model: Targeting Bmal1/Nrf2 Mediated Ferroptosis and Restoring Mitochondrial Mitophagy.Neurochemical research1 mentions
- 2025Ameliorative Potential of Mesenchymal Stem Cells-derived Exosomes on the Cerebellar Cortex in a Rat Model of Parkinson's Disease: Targeting HOTAIR/miRNA-221 Signaling Axis: A Histological, Immunohistochemical, and Biochemical Study.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada1 mentions
- 2025System biology-based assessment of the molecular mechanism of epigallocatechin gallate in Parkinson's disease: via network pharmacology, in-silico evaluation & in-vitro studies.Scientific reports1 mentions
- 2025Decoding the Dialogue: Immunity and central nervous system interactions in neurodegenerative diseases.The Egyptian journal of immunology1 mentions
- 2025Single nucleus RNA sequencing profile analysis to reveal cell type specific common molecular drivers of Parkinson's disease and therapeutic agents.Scientific reports1 mentions
- 2025From Molecules to Medicines: The Role of AI-Driven Drug Discovery Against Alzheimer's Disease and Other Neurological Disorders.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2025Computational association in parkinson's disease SNPs with brain structural and functional alterations.Neurogenetics1 mentions
- 2025Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons.Scientific reports1 mentions
- 2025Parkin, a key player in Parkinson's disease pathogenesis: A review.International journal of biological macromolecules1 mentions
- 2025The Microbiota-Gut-Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders.CNS neuroscience & therapeutics1 mentions
- 2025Taming hyper-active Cdk5: Disrupting the Cdk5-p25 axis as a therapeutic avenue for neurodegeneration and beyond.Pathology, research and practice1 mentions
- 2025Reviving mitochondria to restore the mind: stem cell-based bioenergetic rescue in Parkinson's disease.Neurodegenerative disease management1 mentions
- 2025Transcriptomic Analysis Reveals the Molecular Relationship Between Common Respiratory Infections and Parkinson's Disease.Current issues in molecular biology1 mentions
- 2025Therapeutic Role of Amantadine in Prolonged Postictal Encephalopathy: A Case Report in an Elderly Patient.Case reports in neurology1 mentions
- 2025Fe2+-Sensing α-Synuclein Iron-Responsive Messenger RNA/eIF4F Complex Binding and Regulating mRNA Translation Activation and Repression.International journal of molecular sciences1 mentions
- 2025Unravelling homozygous PLA2G6 variants in Pakistani individuals with diverse clinical manifestations via whole exome sequencing.BMC medical genomics1 mentions
- 2025Targeting the alpha-synuclein protein to treat Parkinson's disease using novel inhibitors identified using an integrated computational drug development approaches.In silico pharmacology1 mentions
- 2025Novel Drug Targets for Neurodegenerative Diseases of Elderly People to Develop Effective Therapeutics: A Comprehensive Analysis.Advances in pharmacological and pharmaceutical sciences1 mentions
- 2025Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson's disease brain.Nature communications1 mentions
- 2025Absence of the LRRK2 mutation in Emirati Parkinson's disease patients in contrast to other Arab populations.Frontiers in aging neuroscience1 mentions
- 2025Implications for the role of natural products in Parkinson disease therapy.Archives of medical science : AMS1 mentions
- 2025Efficacy and Safety of Isotretinoin for Moderate-to-Severe Seborrheic Dermatitis: A Systematic Review of Randomized Controlled Trials.Clinical, cosmetic and investigational dermatology1 mentions
- 2025Multi-Transcriptome-Informed Network Pharmacology Reveals Novel Biomarkers and Therapeutic Candidates for Parkinson's Disease.Genes1 mentions
- 2024Repurposing the inhibitors of MMP-9 and SGLT-2 against ubiquitin specific protease 30 in Parkinson's disease: computational modelling studies.Journal of biomolecular structure & dynamics1 mentions
- 2024Oxidative Stress and Dopaminergic Metabolism: A Major PD Pathogenic Mechanism and Basis of Potential Antioxidant Therapies.CNS & neurological disorders drug targets1 mentions
- 2024Structural and dynamics insights into the GBA variants associated with Parkinson's disease.Journal of biomolecular structure & dynamics1 mentions
- 2024Pharmacological update of mirtazapine: a narrative literature review.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2024The SH-SY5Y cell line: a valuable tool for Parkinson's disease drug discovery.Expert opinion on drug discovery1 mentions
- 2024The AfrAbia+plus Parkinson's Disease Genomic Consortium.The Lancet. Neurology1 mentions
- 2024Retinal Alterations Predict Early Prodromal Signs of Neurodegenerative Disease.International journal of molecular sciences1 mentions
- 2024Oxidative stress and ion channels in neurodegenerative diseases.Frontiers in physiology1 mentions
- 2024Molecular insights into codon usage analysis of mitochondrial fission and fusion gene: relevance to neurodegenerative diseases.Annals of medicine and surgery (2012)1 mentions
- 2024Parkinson's Disease and MicroRNAs: A Duel Between Inhibition and Stimulation of Apoptosis in Neuronal Cells.Molecular neurobiology1 mentions
- 2024Potential Applications of Mitochondrial Therapy with a Focus on Parkinson's Disease and Mitochondrial Transplantation.Advanced pharmaceutical bulletin1 mentions
- 2024ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease.Ageing research reviews1 mentions
- 2024Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases.Molecular neurobiology1 mentions
- 2024Autophagy-associated non-coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis.CNS neuroscience & therapeutics1 mentions
- 2024Hidden regulators: the emerging roles of lncRNAs in brain development and disease.Frontiers in neuroscience1 mentions
- 2024Increased glucosylsphingosine levels and Gaucher disease in GBA1-associated Parkinson's disease.Parkinsonism & related disorders1 mentions
- 2024Combating Parkinson's disease with plant-derived polyphenols: Targeting oxidative stress and neuroinflammation.Neurochemistry international1 mentions
- 2024Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits.Ageing research reviews1 mentions
- 2024Unlocking the potential of edible Ulva sp. seaweeds: Metabolomic profiling, neuroprotective mechanisms, and implications for Parkinson's disease management.Archiv der Pharmazie1 mentions
- 2024Non-coding RNAs in Parkinson's disease: Regulating SNCA and alpha-synuclein aggregation.Pathology, research and practice1 mentions
- 2024Hesperetin protects against rotenone-induced motor disability and neurotoxicity via the regulation of SIRT1/NLRP3 signaling.Toxicology mechanisms and methods1 mentions
- 2024The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives.Journal of integrative neuroscience1 mentions
- 2024Therapeutic use of music in neurological disorders: A concise narrative review.Heliyon1 mentions
- 2024Unveiling Lobophytum sp. the neuroprotective potential of Parkinson's disease through multifaceted mechanisms, supported by metabolomic analysis and network pharmacology.Scientific reports1 mentions
- 2024Computational Design and Optimization of Peptide Inhibitors for SIRT2.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2024Interplays Between Matrix Metalloproteinases and Neurotropic Viruses: An Overview.Reviews in medical virology1 mentions