MMP2
HGNC:7166 · 26 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP2 | “Pairwise analysis of senescence-related gene expression (LMNB1, MKI67, CDKN1A, ATM, IGFBP7, MMP2, CXCL14, and CCL5) was performed in an independent geneset of 68 paired pre- and post-NAC BC patient samples.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “RESULTS: We categorised recurrently dysregulated genes by their biological function, including transcription factors (SOX2, ZEB2), growth factor receptors (EGFR, PDGFRA), immune-related markers (PD-L1, TAP1, B2M), extracellular matrix regulators (MMP2, LAMC1, HAS2), and metabolic genes (SLC7A11, PRMT5, NRF2).” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “In addition, Shilajit raised the protein levels of MMP2 and MMP9, two important enzymes involved in tissue remodeling.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “RESULTS: Combining the results of network pharmacology with other bioinformatics databases suggests that myrrh's active components exert anti-cancer effects by regulating genes involved in breast cancer pathogenesis, particularly PTGS2, EGFR, ESR2, MMP2, and JUN.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “ALB, ACHE, TYMS, PRKCD, PLG, MMP9, MMP2, ERN1, EDNRA, BRD4 were found to be associated with MRSA infection.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Treatment with AQ and AQ with paclitaxel consistently decreased the expression of crucial marker genes such as MMP2 and MMP9.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “In this comprehensive study, we investigated the intricate roles of two important wound healing genes in SKCM, including Matrix Metalloproteinase-2 (MMP2) and Matrix Metalloproteinase-9 (MMP9).” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Identifying and validating MMP family members (MMP2, MMP9, MMP12, and MMP16) as therapeutic targets and biomarkers in kidney renal clear cell carcinoma (KIRC).” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “The PTGS2, MMP2 and PTGS1 were the top annotated genes related to gastric ulcer.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “NFX has potential roles in inhibiting thyroid, breast, lung, bladder, liver, and colon cancers and osteosarcoma, melanoma, and others mediated by suppressing STAT3 as well as ALDH1, MMP2, MMP9, Bcl2 and upregulating Bax.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Additionally, in the SW480 cell line, although TNF-α treatment selectively induced expression of a marker of metastatic progression VEGF-A, it failed to affect MMP2 expression or invasion activity.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “On the other hand, specific mutations in ABCC1, ADIPOQ, CYP1A1, KIR, IL-17A, MMP2, NOTCH3, PRNCR1, RETN, TDG, TLR2, BRAF, PARP-1, TLR4, TLR-9, TNF-α, TSLP and XRCC1 genes demonstrated a substantial augmented CRC risk development in Saudi patients.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “The SPRK1, MMP2, MMP9, AKT, mTOR, etc., genes, and noncoding RNAs (miRNAs, lncRNAs, circRNAs, etc.) were shown mostly to be implicated in the metastases of glioma.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Eight SNPs of the MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, and MMP12 genes and their gene-gene (epistatic) interactions were analyzed for association with EH in a cohort of 939 patients and 466 controls using logistic regression and assuming additive, recessive, and dominant genetic models.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Gene-based analysis indicated that multiple genetic variants in AMELX showed joint association with the risk of dental caries (6 variants; P < 10-5), so did genetic variants in MMP13 (3 variants; P = 0.004), MMP2 (3 variants; P < 10-5), MMP20 (2 variants; P < 10-5) and MMP3 (2 variants; P < 10-5).” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Single nucleotide polymorphisms in matrix metalloproteinase 2 (MMP2) enhance BRAFV600E mutation-mediated oncogenicity and invasiveness of papillary thyroid cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Ten SNPs of the MMP1 (rs1799750), MMP2 (rs243865), MMP3 (rs679620), MMP8 (rs1940475), and MMP9 (rs3918242, rs3918249, rs3787268, rs17576, rs17577, and rs2250889) genes were considered for association with GU using multiple logistic regression.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Network construction ultimately lead to the identification of nine gene named FN1, EGR1, FOS, JUN, SERPINE1, MMP2, ATF3, MYC, and IL1B and one novel key miRNA namely, has-miR-144-3p as biomarker for diagnosis and therapy of IgAN.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “The aim of this study was to determine the genetic association of MMP2, MMP7 and MMP9 promoter polymorphisms with colorectal cancer (CRC) susceptibility and development risk in ethnic Kashmiri population.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Matrix metalloproteinase-2 (MMP2) is an endopeptidase, mainly responsible for degradation of extracellular matrix components, which plays an important role in cancer disease.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “AIM: Tissue inhibitor of metalloproteinase (TIMP2) is involved in the regulation of matrix metalloproteinase 2 (MMP2) and shown to implicate in cancer development and progression.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Several polymorphisms within the MMP2 promoter region have been reported in cases with oncogenesis and tumor progression, especially in colorectal carcinogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defects.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “We previously described and then demonstrated that the novel autosomal recessive osteolysis/arthritis syndrome, multicentric osteolysis with arthritis (MOA) (MIM #605156), was caused by inactivating mutations in the MMP2 gene [Al Aqeel, A., Al Sewairi, W., Edress, B., Gorlin, R.J., Desnick, R.J. and Martignetti, J.A. (2000) Inherited multicentric osteolysis with arthritis: A variant resembling Torg syndrome in a Saudi family.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “CONCLUSION: The discovery that deficiency of this well-characterized gelatinase/collagenase results in an inherited form of an osteolytic and arthritic disorder provides an invaluable insights for the understanding of osteolysis and arthritis and is the first genetic evidence that MMP2 deficiency is important in growth and development.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome.” | 0.98 | hgnc_dict_v1 |