MMP9
HGNC:7176 · 50 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “Furthermore, the expression of SASP-related genes, including MMP3, MMP9, CXCL8, and TGF-β1 (but not IL-1A), was increased, albeit non-significantly, suggesting a potential opportunity to detect transcriptional SASP changes in 3D bioprinted tumor cell models.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “We further identified 201 common upregulated hub genes (including MMP9, CDH1, HSP90AB1, SOX2, CDKN2A, SPP1, EZH2) and 224 common downregulated hub genes (such as IL6, TNF, IL1B, JUN, CCL2, TLR4, FOS, PTGS2).” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Protein-protein interaction analysis identified ten hub genes, including AKT1, STAT3, EGFR, and MMP9, representing highly connected nodes within the predicted interaction network.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Notably, Otostegia fruticosa downregulated MMP9 and OPN protein expressions, while upregulating caspase-9 and Cyt-c.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Cross-referencing polyphenol-associated targets with GBM-related genes identified 13 common targets (e.g., PTGS2, EGFR, ESR1, MMP9).” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Serum biochemical markers (ALT, AST, urea, and creatinine) were quantified, while tumor tissues were analyzed for apoptotic (caspase-3, Bcl2), inflammatory (IL1β), angiogenic (VEGF), metastatic (MMP9), and antioxidant (Nrf2, HO-1) genes using qPCR.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Analysis of the miRNA online database revealed that the miRNA targets were casp9, IL7, IL7R, JUN, MMP9, Bcl2, and SMAD4.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “The selected upregulated genes involved in inflammatory response, glycosylation, and death-like domains, according to the functional network analysis of pGDM (TNFAIP6, PDK3) and T2D (MMP9 and CARD6), showed similar trends to those obtained via microarray.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “In Group II, genes such as LIF, LBP, CSF3, IL6, CCL2, SAA1, CCL20, MMP9, CXCL10, and MMP1 were found to be involved in the transformation to adult glioblastoma.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “In addition, Shilajit raised the protein levels of MMP2 and MMP9, two important enzymes involved in tissue remodeling.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “METHODS: We utilized a set of patient-derived premalignant and malignant tissue samples to investigate the protein (Ki67 and Lamin B1) and gene (TP53, IL1A, CCL2, and MMP9) expression of several OIS-associated biomarkers using immunohistochemistry (IHC) and qRT-PCR, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Aloe arborescens Standardized Glycosidic Fraction Suppresses Hepatocarcinoma by Modulating TIMP1, MMP9 Genes Expression, and Inflammation/Ki67/TGFβ1 Pathway. (1) Background and aim: Aloe arborescens Mill. ( A. arborescens ) is one of the most widely distributed species in the genus Aloe and has garnered widespread recognition for its anticancer properties.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Platelet-rich plasma enhances remodeling of combined gastrocnemius muscle and Achilles tendon injuries in rat model: Reducing fibrosis, modulating gene (MMP9, Bax, HMGB1, and IGF) expression, and restoring histopathological and ultrastructural changes.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “We used a set of patient-derived precancerous (n = 32) and noncancerous (chronic cervicitis; n = 10) tissue samples to investigate the gene expression of several OIS (LMNB1, CDKN2A, CDKN2B, and CDKN1A), and SASP (IL1A, CCL2, TGFB1, CXCL8, and MMP9) biomarkers using qRT-PCR.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Key targets like MMP9, EGFR, and AKT1 were highlighted, and the PPAR and PI3K-AKT signaling pathways were identified as the primary mechanisms through which CT may treat DN.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Preliminary investigation of MMP8 (rs11225395) and MMP9 (rs3787268) polymorphisms association with breast cancer risk in pashtun women of Pakistan.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Moreover, we identified that elevated expression of MMP9 is associated with worse overall survival in ESCC patients, which may serve as potential prognostic biomarker or therapeutic target for ESCC.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Additionally, in silico modeling was particularly targeting matrix metalloproteinase-9 (MMP9), a key player in wound healing processes.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “RESULTS: Our study demonstrated a non-significant difference in the genotype and allele frequencies of the MMP9 rs17576 polymorphism between the patients with IS and patients with ACS without IS (P = 0.31 for the GA genotype, 0.25 for the AA genotype and P = 0.20 for the A allele).” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “ALB, ACHE, TYMS, PRKCD, PLG, MMP9, MMP2, ERN1, EDNRA, BRD4 were found to be associated with MRSA infection.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Survival and network analysis revealed that five genes named heat shot protein 90 AA1 (HSP90AA1), estrogen receptor 1 (ESR1), cytochrome P450 3A4 (CYP3A4), cyclin-dependent kinase 1 (CDK1), and matrix metalloproteinase-9 (MMP9) are linked with the survival of LC patients.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Treatment with AQ and AQ with paclitaxel consistently decreased the expression of crucial marker genes such as MMP2 and MMP9.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Top hub genes identified were TLR4, MMP9, MAPK14, AKT1, VEGFA and HSP90AA1 with their respective associates.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “In this comprehensive study, we investigated the intricate roles of two important wound healing genes in SKCM, including Matrix Metalloproteinase-2 (MMP2) and Matrix Metalloproteinase-9 (MMP9).” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Identifying and validating MMP family members (MMP2, MMP9, MMP12, and MMP16) as therapeutic targets and biomarkers in kidney renal clear cell carcinoma (KIRC).” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “The hepatic expression of mRNA and protein levels of TGF-β1, β-catenin, SMAD4, matrix metalloproteinase-9 (MMP9), phosphoinositide 3-kinases (PI3K), mammalian target of rapamycin (mTOR), connective tissue growth factor 2 (CCN2), E-Cadherin, platelets derived growth factor (PDGF)-B and fascin were also analyzed.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Renal tissue was collected to assess matrix metalloproteinase-9 (MMP9), inflammatory and apoptotic markers: tumor necrosis factor-alpha (TNF- β, caspase-3, cyclo-oxygenase-2 (COX-2), and oxidative stress markers: nitric oxide (NO), Glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD).” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “LncRNA ILF3AS1, MMP3, and MMP9 as well as miRNA-212 as emerging novel biomarkers for childhood epilepsy.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Matrix metalloproteinase 9 (MMP9) and microRNA-145 (miR-145) have emerged as essential biomarkers in thyroid cancer progression and metastasis.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “WKO and WKD extracts improved rat BM-MSC stemness, as evidenced by (1) increased cell viability, (2) decreased apoptosis (low levels of Bax and caspase3 and high levels of Bcl2), (3) upregulated MMP9 and downregulated TIMP1 expression, and (4) cell cycle arrest in the G0/G1 phase and declined cell number in the S and G2/M phases.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “The results revealed 36 phytocompounds that interacted with 1431 receptors in the human body, and two compounds - hederagenin and quercetin - showed exceptionally high binding affinities toward their corresponding receptors, IL6 and MMP9.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Diarylheptanoids/sorafenib as a potential anticancer combination against hepatocellular carcinoma: the p53/MMP9 axis of action.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Gene expression study showed that the developed wound dressings reduced the tissue expression levels of glutathione peroxidase, NFKβ, and matrix metalloproteinase 9 (MMP9) genes.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “NFX has potential roles in inhibiting thyroid, breast, lung, bladder, liver, and colon cancers and osteosarcoma, melanoma, and others mediated by suppressing STAT3 as well as ALDH1, MMP2, MMP9, Bcl2 and upregulating Bax.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “BACKGROUND: The polymorphisms of the cyclin-dependent kinase inhibitor (CDKN1A) gene and matrix metalloproteinase-9 (MMP9) gene may increase one's susceptibility to malignancies.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “The SPRK1, MMP2, MMP9, AKT, mTOR, etc., genes, and noncoding RNAs (miRNAs, lncRNAs, circRNAs, etc.) were shown mostly to be implicated in the metastases of glioma.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Functionally significant polymorphisms of the MMP9 gene are associated with primary open-angle glaucoma in the population of Russia.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Heart specimens are used for evaluation of cellular oxidative stress markers malondialdehyde (MDA), antioxidant enzymes, glutathione (GSH), and catalase (CAT), as well as mRNA expression of TGF-β, MMP9, IL-1β, and TNF-α.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Finally, core hub genes (EGR1, MMP9, and CD44) were validated using RT-PCR analysis.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Eight SNPs of the MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, and MMP12 genes and their gene-gene (epistatic) interactions were analyzed for association with EH in a cohort of 939 patients and 466 controls using logistic regression and assuming additive, recessive, and dominant genetic models.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “A Multi-target Drug Designing for BTK, MMP9, Proteasome and TAK1 for the Clinical Treatment of Mantle Cell Lymphoma.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Novel Data about Association of the Functionally Significant Polymorphisms of the MMP9 Gene with Exfoliation Glaucoma in the Caucasian Population of Central Russia.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Upregulated genes preferentially associated with other gene ontologies (GO) were, e.g., STAT1, MMP9, TOP2A, and BRCA2.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Data on the allele and genotype frequencies of the three functionally significant single nucleotide polymorphisms (SNPs) of the matrix metalloproteinases (MMP) genes (rs1799750 MMP1, rs3918242 and rs17576 MMP9) in Russian patients with primary open-angle glaucoma (POAG), essential hypertension (EH) and peptic ulcer (PU) are presented.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “This study aim to investigate the association of breast cancer risk and prognostic factors with single nucleotide variants of the BRCA1, BRCA2, DAPK1, MMP9, TOX3, and TP53 genes in Jordanian women.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “The aim of this study was to determine the genetic association of MMP2, MMP7 and MMP9 promoter polymorphisms with colorectal cancer (CRC) susceptibility and development risk in ethnic Kashmiri population.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “RESULTS: We found that diabetic mice exhibited delayed wound closure characterized by a significant decrease in the levels of TGF-β1 and a prolonged elevation of the levels of inflammatory cytokines (IL-1β, IL-6 and TNF-α) and MMP9 in wound tissues compared with control non-diabetic mice.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.” | 0.98 | hgnc_dict_v1 |