SOD2
HGNC:11180 · 27 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD2 | “The opposing roles of certain antioxidant enzymes, such as Mn-SOD (SOD2), illustrate the same duality as ROS, acting as potential tumor suppressors during early carcinogenesis and as tumor promoters during metastasis.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Antioxidant enzymes SOD2, GPX1, and GPX4 were reduced by 75.2% (P < 0.001), 90.1% (P < 0.001), and 83.2% (P < 0.001), respectively.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Additionally, antioxidant enzyme activities (SOD, CAT), markers of lipid peroxidation (MDA, NO), and mRNA expression levels of genes related to oxidative stress (Nrf2, SOD2), apoptosis (Bax, Bcl-2), lipid metabolism (PPAR-α), and DNA damage (p53) were evaluated using quantitative RT-PCR.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Gene Ontology analysis showed that MDHB exerts multifaceted antifungal activity through membrane destabilization (47 membrane-associated genes affected), suppression of energy metabolism via downregulation of ATP-binding proteins and proton-pumping ATPases, oxidative stress induction through impairment of superoxide dismutase (SOD2) and antioxidant systems.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “The toxicity-induced gene expression studies indicated that the EGCG upregulated the targets SOD2, FOXO1, and GPx.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Six liver-metabolism-related DEGs, SOD2, SOD1, CD19, IGF1, HK2, and PFKFB3, were expressed differently among the three sheep groups.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “RES was shown to mitigate the effect of PA on macrophages bioenergetics and the oxidative damage and counteracted PA effect on genes linked to oxidative damage, such as Nrf2, Ho-1, NF-κB p65, SOD1, and SOD2.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Potential Impact of SOD2 (rs4880; p.Val16Ala) Variant with the Susceptibility for Childhood Bronchial Asthma.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Further, RT-PCR and Western blot analysis validated the expression of target genes including the overexpression of HSPA1B, FOS, and down-expression of SOD2, COL1A1, and CCL2, whereas TFs including upregulation of RELA, NFKB1, STAT3, and downregulation of SP1 and JUN in diabetic and diabetic infectious wounds.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “The key host genes involved in immune responses (e.g., BoLA-DRB3 and TLR4), oxidative stress defense (SOD2 and GPX1), drug metabolism (ABCB1 and CYP3A4), and ectoparasite resistance (MC1R and MHC) have been identified as contributors to resistance phenotypes.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “The BPA administration also induces ROS production, which decreases the expression of antioxidant genes Superoxide dismutase 1 (SOD1), Superoxide dismutase 2 (SOD2), Catalase (CAT), Glutathione peroxidase 1 (GPX1), and Forkhead box O3 (FOXO3) in ovarian cells.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “METHODS: The current study was designed to explore the effect of observing four-week, dawn to dusk IF by participants with obesity on gene expression of the anti-inflammatory CD163, oxidative stress, and bioenergetics enzymes (SOD2, Nrf2, and TFAM), as well as metabolic and cellular regulatory genes (SIRT1 and SIRT3).” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Notably, the expression of three important aging-related genes, SIR2, SOD1, and SOD2, showed a significant difference following PLME treatment.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “In this investigation, we explored whether these strains had any differences in pulmonary oxidant-antioxidant system (Nrf2, SOD2, iNOS, HO-1, nitrotyrosine) in different immune cells (DCs, AMs, neutrophils, T cells), airway inflammation (presence of eosinophils and/or neutrophils) and mucus production in response to repeated cockroach allergen extract (CE) mouse model of asthma.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “SOD2 significantly increased (p value = 0.016) in smokers after vitamin C exposure.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Nanoceria pretreatment increased the mRNA levels of genes regulating the cellular antioxidant defense system (SOD2, MnSOD, CAT) in Ang II-treated cells.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Association SOD2 and PON1 Gene Polymorphisms with Polycystic Ovary Syndrome in Saudi Women.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Evaluation of each group was via histopathological examination, assessment of gene and/or protein expression concerned with oxidative stress (SOD1, SOD2, Nox2, Nox4, iNOS), inflammation (TNF-α, ICAM-1, NF-κB) and angiogenesis (VEGF, VE-cadherin).” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Gene expression of catalase, superoxide dismutase (SOD1, SOD2), and glutathione peroxidase (GPx) are changed twice, thrice, and quadruplet, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Among them were MAP2K1, RPL23A, RPS3, CALR, PRDX1, SOD2, LMNB1, PHB, and FGB.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Molecularly, SME significantly upregulated antioxidant gene expression (SOD2, GR, GPx1, and CAT) caused by Cd.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “DEGs (MCM2, TCF4, OLR1, HSPA5, MAP1LC3B, SQSTM1, NEU1, HIST1H1B, RAD51, RFC3, MCM10, ISG15, TNFRSF10B, GBP2, IGFBP5, SOD2, DHF and MT1H) , which were significantly up- and down-regulated in estradiol and tamoxifen-treated BRCA samples, were selected as hub genes according to the results of protein-protein interaction (PPI) network, module analysis, target genes-miRNA interaction network and target genes-TF interaction network analysis.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “This study investigated the effects of type 1 diabetes (T1D), type 2 diabetes (T2D), and HT on the expression levels of SIRT1, SIRT3, and manganese superoxide dismutase (SOD2).” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Genetic polymorphisms in NQO1 and SOD2: interactions with smoking, schistosoma infection, and bladder cancer risk in Egypt.” | 0.98 | hgnc_dict_v1 |