BAX
HGNC:959 · 95 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “DMH also inhibited apoptosis, as demonstrated by reduced expression of BAX, caspase-3, and TP53, along with increased BCL-2 expression.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Notably, the increase in BAK and BAX expression suggests a possible link to the apoptotic response in HCT-116 cells.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Upregulation of P53 and BAX following PDT was greatly enhanced, and BCL2 expression was significantly reduced as compared to wild-type groups.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “By repressing the anti-apoptotic BCL-2 gene and increasing the pro-apoptotic BAX gene, the two therapies mechanistically produced cell death.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Furthermore, gene expression profiling demonstrated significant upregulation of pro-apoptotic markers (BAX, Caspase-3), downregulation of anti-apoptotic BCL-2, and modulation of oncogenic and cell cycle regulatory pathways, including CDK1, Cyclin B1, p21, c-MYC, and PI3K/AKT/mTOR signaling.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Protein expression validation was performed using immunofluorescence microscopy and qRT-PCR analysis targeting key apoptotic genes (p53, BAX, BCL-2, CASP3, Cyclin D1).” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Compounds 9 and 10 showed the greatest gene expression downregulation of BAX by 75.1% and 79.7%, and upregulation of Bcl-2 gene expression by 8.1 folds for each.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Gene expression analysis showed upregulation of COX-2, iNOS, TNF-α, FAS, and BAX and downregulation of PIK3CD and BCL-2, indicating inflammation and impaired survival signaling.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Gene expression analysis using qRT-PCR examined key apoptosis-related markers (TP53, BAX, BCL2, CASP3).” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Rheumatic arthritis disease activity using the titer of rheumatoid factor (RF), markers of inflammation, and the apoptotic BAX gene was assayed.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “G-phase cell-cycle arrest, increased apoptosis (57.36%), and changes in apoptosis-related genes, such as downregulating Bcl-2 and upregulating p53, caspase-9, and BAX, were all found by mechanistic investigations.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “CuFe2O4 NPs modified with MK exhibited significant cytotoxicity against MCF-7 cells, yielding an IC₅₀ of 48.94 µg/ml and a notable 45% reduction in BCL-2 expression, while BAX expression experienced a marginal 3.4% rise.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Gene expression analysis supported activation of apoptotic pathways demonstrated by upregulation of BNIP3, the BAX/BCL-2 ratio (p < 0.05), and disruption of mitochondrial homeostasis.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Gene expression studies showed significant down regulation of PD-L1, EGFR, STAT3, BCL2 and Ki-67, while the up regulation of Caspase-3, Caspase-9 and BAX (p < 0.0001).” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “To explain the mode of molecular action of compounds on cells, we tested the mRNA levels of apoptotic and antiapoptotic genes such as BAX, BCL2, BCL2-xl, BiD, and caspase 3 by qRT-PCR.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Cell viability was evaluated using the MTT assay, while the expressions of PI3K/AKT/mTOR pathway genes and apoptosis genes, BAX and BCL-2, were analyzed by qRT-PCR.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “In vitro cytotoxicity against HeLa cells demonstrated enhanced anticancer activity for the MnFe₂O₄/GO composite (IC₅₀ = 120.7 µg/mL) compared to MnFe₂O₄ (IC₅₀ = 200.7 µg/mL) and GO (IC₅₀ = 1202 µg/mL), indicating a synergistic effect. qPCR analysis showed significant upregulation of pro-apoptotic genes (BAX, Caspase-3) and downregulation of the anti-apoptotic gene (Bcl-2), confirming apoptosis induction as a key mechanism of action.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Flow cytometry and gene expression analysis revealed that 7b induces G1-phase cell-cycle arrest and promotes apoptosis through the upregulation of BAX, caspases-8/9, and downregulation of Bcl-2.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Folate- and chitosan-functionalized lipid nanoparticles for co-delivery of pioglitazone and simvastatin to enhance hepatic cancer therapy: effects on IL-1β, IL-6, BCL2/BAX gene expression, and GPX4, COX-2, and MMP-9 activities.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Gene expression analysis of SOD1, CAT, NF-κB, TNF-α, IL-1β, BCL2, BAX, MBP, and Syn2a provided molecular evidence of disrupted antioxidant defenses, impaired myelin formation, altered synaptic function in the brain, inflammatory responses, and increased apoptosis in the ovaries.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Colon samples were collected to evaluate gene and protein expression of various factors, including nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), tumor necrosis factor alpha (TNF-α), sphingosine kinase 1 (SphK1), macrophage inflammatory protein 1-alpha (MIP-1α), B-cell lymphoma 2 (BCL2), and BCL2 associated X (BAX), as well as the activities of caspase-3/8/9.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Additionally, the titled compounds caused a significant decrease in Bcl-2 expression levels, a significant increase in caspase-3, caspase-9, and BAX gene expression levels, and a suppression of TNF-α and IL-6R protein levels, indicating their significant apoptotic impact.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “RESULTS: The study identified 94 DEGs, of which 55 genes were remarkably upregulated, including CASP8, ZHX2, BCL2L1, CTNNB1, RB1, BAX, CD274, CCL20, FOXP3, and CCL18.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The downregulation of ESR1 led to G0/G1 cell cycle arrest and apoptosis through the activation of downstream pathways, resulting in increased expression of TP53 and BAX, while reducing Bcl2 levels, ultimately leading to apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Additional benefits included downregulating stress-related mRNA markers (HSP1A1 and TNC) and apoptotic markers (BAX and TP53).” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The PD group exhibited a substantial increase in relative cerebellar mRNA HOTAIR, BAX, and caspase 3 gene expression, along with a concomitant decrease in relative cerebellar miRNA-221 gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Treatment with 7b increased the expression of the proapoptotic gene BAX (4.19 ± 0.34-fold) and suppressed the expression of the antiapoptotic gene Bcl-2 (0.38 ± 0.02-fold), resulting in a dramatic increase in the BAX/Bcl-2 ratio (11.03 ± 1.66-fold).” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Small intestine, muscle tissues, and serum samples were collected to assess parasitic load, histopathological changes, TGF-β immunohistochemical expression, serum IFN-γ levels, oxidative stress markers (MDA, nitrate/SOD, and catalase), and BAX gene expression as an apoptotic marker.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “In PC3 cells, the extract induced oxidative stress markers (MDA: 13.63 μmol mg-1; NO: 66.13 μmole per mg), modulated antioxidant enzyme activities, upregulated antioxidant genes (CAT: 1195%, SOD: 788%, GPx: 473%, GST: 251%), increased DNA damage (205.1%), activated apoptotic pathways via BCL-2 downregulation and BAX/P53/Caspase-3 upregulation, and induced G1 phase arrest (72.97%).” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Mechanistic investigations indicated that their cytotoxicity involved programmed cell death induction, as evidenced by increased protein expression of caspase-7, cytochrome C, BAX, and p53, as well as reduced BCL-2 protein levels, along with sub-G1 cell cycle cessation via cyclin-dependent kinase genes expression downregulation.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Apoptosis was assessed through gene expression analysis of BAX/Bcl-2, caspase-8, and caspase-9, alongside flow cytometry for apoptosis and cell cycle analysis.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Gene and protein expression of molecules involved in apoptosis (BLC2, survivin, BAX, Cytochrome-C, and Caspase-3), cell cycle (CCND1, CCND3, p21, and p27), the PI3K/AKT/mTOR/HIF1α oncogenic pathway, and glycolysis (LDHA, PDH, and PDHK1) were also analysed by quantitative RT-PCR and Western blot.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Apoptotic gene expression showed a significant downregulation of caspase-3 and BAX, with BCL2 upregulation.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “CD133 knockout in BAKP cells increased trametinib-induced apoptosis by reducing anti-apoptotic p-AKT and p-BAD and increasing pro-apoptotic BAX.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “It significantly inhibited VEGFR-2 and altered gene expression, promoting BAX, P21, and P53 while downregulating BCL-2.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “By Increasing BAX protein expression; decreasing VEGF and Bcl-2 expression it can initiate cell cycle arrest and apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Concurrently, fish that were fed a 2.0 mL TTO/kg diet exhibited a substantial upregulation of TNF-α, IL-1β, IL-10, TFG-β, IFN-γ and BCL-2 genes in the liver, while, caspase-3, and BAX were downregulated.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Notably, DASA treatment upregulated the gene expression of the pro-apoptotic gene BAX while downregulating the expression of BCL-2 and Caspase-3 in kidney tissues.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Additionally, mRNA expression levels of Matrix metalloproteinase-9 (MMP-9), Pro-apoptotic Bcl-2 Associated-X-protein (BAX), Insulin-like growth factor (IGF), and High mobility group box 1 protein (HMGB1) genes were evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Studies on gene expression (Bcl2, P53and BAX) were conducted to assess the molecular mechanism of apoptosis mediated by synthesized nanoparticle and level of matrix metalloproteinase -2 (MMP-2) by gelatin zymography.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “RESULTS: Autistic Group (III) showed an increment in levels of MDA, IL-6, IL12 and BAX while showing a decrement in SOD, Bcl-2 and Beclin-1 as well as increased PI3k, Akt and mTOR gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Glyphosate upregulated pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), increased TLR-4 and NOS2 expression, activated mitochondrial apoptosis by increasing pro-apoptotic proteins (BAX, CYTOCHROME C, and CASPASE-3) while decreasing anti-apoptotic BCL-2 protein levels, with corresponding changes in gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “In addition, the gene expression level of immune responses related cytokines (IFN-γ, IL-4, and IL-12) as well as apoptosis (Caspase-3, Bcl-2, and BAX) and pathogenesis-related genes (BAG1) were analyzed using quantitative reverse transcription polymerase chain reaction (Real-time-PCR).” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “In the same context, DOX was found to have a remarkable downregulation in Nrf2, HO-1, Sirt-1, and Bcl2, while the upregulation of NF-κB, TNF-α, and BAX gene and protein expression occurred.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Similarly, the PCR test showed significant declines in the expression of the Wnt (0.36), and β-catenin (0.33) genes, but increased caspase-3 (3.54-fold) and BAX (5.36-fold) genes in the SGL group; all these parameters were improved in the naringin 50 or 100 mg/kg groups.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “MSCs-EVs administration to OF rats resulted in restored serum hormonal levels, preserved primordial follicles and oocytes, suppressed ovarian PI3K/AKT axis and downstream effectors (mTOR and FOXO3), modulated miRNA that target this axis, decreased expression of ovarian apoptotic markers (BAX, BCl2) and increased expression of proliferation marker Ki67.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “In plants, the BAX inhibitor-1 (BI-1) gene plays a crucial part in controlling cell death under stress conditions.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “PARP-1 inhibition reduced HG-induced inflammatory response, including NF-kB, IL6, IL1β, TNFα, iNOS, and TGF-β expression, and HG-induced apoptosis response, such as Cas-3, Cas-9, BAK, BAX, and AIF expression.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “These findings were corroborated by RT-PCR analysis, revealing a significant downregulation of the anti-apoptotic gene Bcl2 and upregulation of the pro-apoptotic gene BAX in compound 18b-treated cells compared to control MCF-7 cells.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The apoptosis process was exhibited by a significant elevation of caspases 3 and 8 activities with overexpression of mRNA BAX, inhibition of BCL-2, and a significant upregulation of the BAX/BCL-2 ratio.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Retraction Note: Ruthana date extract inhibited proliferation of human hepatocellular carcinoma (HepG2) cells by modulation of BAX gene.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Moreover, the vanillic acid nanocomposite exhibited anticancer effects by increasing the expression of pro-apoptotic proteins (BAX, Casp3, Casp7, cyt C, and p53) and decreasing the gene expression of Bcl-2.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Besides, qRT-PCR analysis was conducted showing the potential of the promising hits to downregulate HIF-1a, VEGF, and BCL-2 as well as their ability to enhance the expression of proapoptotic genes p21, p53, and BAX in HCT-116 cells.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “In addition, the qRT-PCR technique authenticates the A. fragrantissima -induced apoptotic network genes (Caspase-3, Caspase-8, Caspase-9, Cytochrome c, BCL-2, BID, BAX, PARP, PTEN, PI3K, and Akt) expression were evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Regarding gene expression, WJ-MSCs and VPA decreased BAX and TGF-β1, up-regulated Akt, PI3K, BCL2, SDF1α, and CXCR4 related to IRI.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Unraveling the intricate mechanism of apoptotic activity, ZnO-CU NPs orchestrated the upregulation of pivotal genes, including BCL2, BAX, and P53, within the KB cells.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The mechanism of action of apoptotic activity of ZnO-CA NPs on the KB cells was identified through the upregulation of BCL-2, BAX, and P53 genes.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “We investigated cardiac enzymes, histopathology, and the mRNA expression of Nrf2, NF-κB, BAX, and tumor necrosis factor-α (TNF-α).” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The relative gene expression of pro-apoptotic and anti-apoptotic genes revealed an overexpression of the P53 and BAX genes and a downregulation of the BCL-2 gene by real-time PCR.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Unlocking the diagnostic, prognostic roles, and immune implications of BAX gene expression in pan-cancer analysis.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “An upregulation of the pro-apoptotic genes (BAX and P53) and a downregulation of the anti-apoptotic gene (BCL-2) were observed.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The mechanism by which ZnO-CA NPs induced apoptosis in KB cells was determined by observing an increase in the expression of the BCL-2, BAX, and P53 genes.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Our findings proved that coinfection significantly upregulated the IL-1β, BAX, and Cas-3 genes.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Moreover, ERS-dependent anti-apoptotic (BCL-2) and apoptotic (Caspase-3 and BAX) genes mRNA expression were analyzed.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The expression of the apoptotic gene (Bcl-2 associated X protein, BAX) was up-regulated in fish challenged by C. albicans.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Colon samples were obtained to assess the gene and protein expression of nuclear factor erythroid 2-related factor-2 (Nrf2), heme oxygenase-1 (HO-1), peroxisome proliferator-activated receptor-gamma coactivator (PGC-1), mitochondrial transcription factor A (TFAM), B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3, caspase-8, and caspase-9.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Higher expression levels of caspase3 (p = .0042), caspase8 (p = .0145), caspase9 (p = .0275), and BAX (p = .0202) mRNA were observed in patients who had oligospermia.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Chrysophanol treatment effectively showed an increase in the expression of BCL-2, and Nrf-2 with a decrease in BAX expression confirmed by immunohistochemistry.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The present study aimed to evaluate the expression of vascular endothelial growth factor (VEGF), Bcl-2-associated X protein (BAX), epidermal growth factor receptors (EGFR), ProExTMC, and human telomerase reverse transcriptase (hTERT) and assess their association with survival and clinicopathological characteristics.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Stimulation of apoptosis was achieved by upregulating the expression of BAX and CASP3 genes and downregulating the expression levels of BCL-2 gene.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “SN-CHM may also greatly upregulate the apoptotic gene BAX while considerably downregulating the anti-apoptotic genes BCL2 and BCL-Xl.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Quantitative RT-PCR was used to express interferon-gamma (INF-γ), cyclooxygenase-2 (COX-2), OGG1, BAX, caspase-3, B-cell lymphoma-2 (Bcl-2), and superoxide dismutase (SOD) genes in cardiac tissues, which are correlated with inflammation, antioxidants, and apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Furthermore, gene expression analysis revealed up-regulation of inflammatory biomarkers (TNF-α, IL-6, and IL-1β) and apoptotic markers (P53, BAX), along with down-regulation of the anti-apoptotic biomarker BCL-2 in response to all TKIs.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “It also upregulated the BAX and caspase-3 markers while downregulating the Bcl-2 gene.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Further apoptosis studies revealed that these compounds enhanced gene expression of BAX by 2 folds and suppressed Bcl-2 expression by 4.29-7.75 folds in the treated MCF-7 cells.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Furthermore, mRNA expression analyses for assessing apoptosis, metastasis, and cell cycle-related genes, the results showed that combination therapy significantly inhibits levels of BCL-2, MMP-9, VEGF, and TGF-β while inducing p53, p21, and BAX expression.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Also, OMAE showed a modification in bcl-2, tumor suppressor gene (p53), and Bax levels and influenced the BAX/BCL-2 ratio via releasing the cytochrome C.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The gene expression data revealed that the apoptotic gene BAX is expressed at a higher level than the BCL-2 gene.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Studies of their effects on the apoptotic BAX and antiapoptotic BCL2 genes, molecular docking studies, and absorption, distribution, metabolism and excretion studies were conducted.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Harmoniously, 5b upregulated the BAX and downregulated the Bcl-2 genes by 3-fold and increased the BAX/Bcl-2 ratio by 8.3-fold comparing the untreated A549 cells.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The gene and protein expression of apoptosis (PCNA/survivin/BAX/Cytochrome-C/Caspase-3) and cell cycle (CCND1/CCND3/p21/p27) molecules, the PI3K/mTOR/HIF1α oncogenic pathway, and glycolysis regulatory enzymes were measured by quantitative-PCR and Western blot.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Moreover, we measured gene and protein expression of B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3/8/9, NF-κB, tumor necrosis factor (TNF)-α and IL-1β/4/6/10.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Besides inflammation, we also assessed the apoptosis pathways including the caspases 3 & 9, mTOR, pAKT proteins, and BAX gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “LCZ696 and valsartan ameliorated DCM progression by inhibiting AGEs formation at activity levels; pro-apoptotic markers (BAX/Bcl2 ratio and caspase-3) in mRNA and protein expressions, the NF-κB at mRNA; and protein levels associated with the restoration of elevated proinflammatory cytokines such as the TNF-α, IL-6, and IL-1β at the activity level.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “We treated UC rats with 30 mg/kg cycloastragenol and assessed gene and protein expression levels of SphK, MIP-1α, B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), miR-143, NF-κB, tumour necrosis factor (TNF)-α and active caspase-3.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Furthermore, alteration in the immune-related genes expression (down-regulation of IL-10 and TGF-β and up-regulation of IL-1β, IL-6, IL-8, and TRL-4), hepato-renal dysfunction (elevated ALT, AST, urea, and creatinine), and high levels of serum stress indicators (cortisol and glucose) were markedly evident. sub-lethal Cu toxicity induced significant up-regulation of apoptosis biomarkers involving, nuclear factor-κβ (NF-κβ), Bcl-2 Associated X-protein (BAX), meanwhile, the expression of B-cell lymphoma 2 (BCL2) and Proliferating cell nuclear antigen (PCNA) was remarkably down-regulated.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Furthermore, malathion increased tumor necrosis factor-alpha, the upregulation of IL-1B, BAX, and IFN-β genes, and the downregulation of Nrf2, Bcl2, and HO-1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Moreover, they caused a significant overexpression of TIMP-1, TNF-α, and BAX mRNA levels.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “BAX 335 hemophilia B gene therapy clinical trial results: potential impact of CpG sequences on gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “BCL-2 (-938C>A), BAX (-248G>A), and HER2 Ile655Val Polymorphisms and Breast Cancer Risk in Indian Population.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Furthermore, CA inhibited MTX-induced apoptosis as evidenced by the decreased expression of BAX and caspase-3, and increased Bcl-2 gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “MTX up-regulated BAX expression and caspase 9 immunoreactivity that were ameliorated in HA + MTX group.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “We have also shown that p16INK4A enhances the binding efficiency of p53 to its cognate sequence presents in the CDKN1A promoter in vitro, and both proteins are present at the promoters of CDKN1A and BAX in vivo.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “The combined analysis identified a new risk association for CRC at 2q35 marked by rs992157 (P = 3.15 × 10-8, odds ratio = 1.10, 95% confidence interval = 1.06-1.13), which is intronic to PNKD (paroxysmal non-kinesigenic dyskinesia) and TMBIM1 (transmembrane BAX inhibitor motif containing 1).” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Potential impact of (rs 4645878) BAX promoter -248G>A and (rs 1042522) TP53 72Arg>pro polymorphisms on epithelial ovarian cancer patients.” | 0.98 | hgnc_dict_v1 |