rheumatoid arthritis
SaudiVarKB evidence summary derived from retained literature mentions.
155Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| TNF | HGNC:11892 | 4 | 4 |
| STAT3 | HGNC:11364 | 4 | 4 |
| CD40 | HGNC:11919 | 3 | 3 |
| CRP | HGNC:2367 | 3 | 3 |
| HLA-DRB1 | HGNC:4948 | 3 | 3 |
| PTPN22 | HGNC:9652 | 3 | 3 |
| TLR4 | HGNC:11850 | 3 | 3 |
| ETS1 | HGNC:3488 | 3 | 3 |
| NLRP3 | HGNC:16400 | 2 | 2 |
| NAT2 | HGNC:7646 | 2 | 2 |
| TYK2 | HGNC:12440 | 2 | 2 |
| IL10 | HGNC:5962 | 2 | 2 |
| CYP3A4 | HGNC:2637 | 2 | 2 |
| EGFR | HGNC:3236 | 2 | 2 |
| RELA | HGNC:9955 | 2 | 2 |
| CD44 | HGNC:1681 | 2 | 2 |
| BAX | HGNC:959 | 2 | 2 |
| TRAF6 | HGNC:12036 | 2 | 2 |
| REL | HGNC:9954 | 2 | 2 |
| TNFRSF1A | HGNC:11916 | 2 | 2 |
| CYP2C9 | HGNC:2623 | 2 | 2 |
| AIRE | HGNC:360 | 2 | 2 |
| MYD88 | HGNC:7562 | 2 | 2 |
| CXCR4 | HGNC:2561 | 2 | 2 |
| SLCO1B1 | HGNC:10959 | 2 | 2 |
| TRAF1 | HGNC:12031 | 2 | 2 |
| TNFAIP3 | HGNC:11896 | 2 | 2 |
| TBX21 | HGNC:11599 | 1 | 1 |
| IRF4 | HGNC:6119 | 1 | 1 |
| CHRND | HGNC:1965 | 1 | 1 |
| IL2RA | HGNC:6008 | 1 | 1 |
| G6PD | HGNC:4057 | 1 | 1 |
| DNMT3A | HGNC:2978 | 1 | 1 |
| CFTR | HGNC:1884 | 1 | 1 |
| STAT1 | HGNC:11362 | 1 | 1 |
| MTHFR | HGNC:7436 | 1 | 1 |
| IFIH1 | HGNC:18873 | 1 | 1 |
| TET2 | HGNC:25941 | 1 | 1 |
| CDC42 | HGNC:1736 | 1 | 1 |
| KPNA1 | HGNC:6394 | 1 | 1 |
| AGL | HGNC:321 | 1 | 1 |
| RIPK1 | HGNC:10019 | 1 | 1 |
| ABCB1 | HGNC:40 | 1 | 1 |
| BRD2 | HGNC:1103 | 1 | 1 |
| LDLR | HGNC:6547 | 1 | 1 |
| PIK3R1 | HGNC:8979 | 1 | 1 |
| BRAF | HGNC:1097 | 1 | 1 |
| H19 | HGNC:4713 | 1 | 1 |
| SPAST | HGNC:11233 | 1 | 1 |
| MALAT1 | HGNC:29665 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| rs2476601 | rs2476601 | 2 | 2 |
| rs731236 | rs731236 | 1 | 1 |
| c.683-2A>C | c.683-2A>C | 1 | 1 |
| W620R | W620R | 1 | 1 |
| D358A | D358A | 1 | 1 |
| P1104A | P1104A | 1 | 1 |
| p.W577C | p.W577C | 1 | 1 |
| A252G | A252G | 1 | 1 |
| G894T | G894T | 1 | 1 |
| rs16969968 | rs16969968 | 1 | 1 |
| rs4804803 | rs4804803 | 1 | 1 |
| rs735239 | rs735239 | 1 | 1 |
| rs7975232 | rs7975232 | 1 | 1 |
| rs3135388 | rs3135388 | 1 | 1 |
| rs2231137 | rs2231137 | 1 | 1 |
| rs4149117 | rs4149117 | 1 | 1 |
| rs7311358 | rs7311358 | 1 | 1 |
| rs2306283 | rs2306283 | 1 | 1 |
| rs4149056 | rs4149056 | 1 | 1 |
| rs2075876 | rs2075876 | 1 | 1 |
| rs4810485 | rs4810485 | 1 | 1 |
| rs6457617 | rs6457617 | 1 | 1 |
| rs10818488 | rs10818488 | 1 | 1 |
| rs699947 | rs699947 | 1 | 1 |
| rs1801268 | rs1801268 | 1 | 1 |
| rs772226819 | rs772226819 | 1 | 1 |
| rs121434568 | rs121434568 | 1 | 1 |
| rs193922816 | rs193922816 | 1 | 1 |
| rs3826711 | rs3826711 | 1 | 1 |
| rs267606617 | rs267606617 | 1 | 1 |
| rs267606618 | rs267606618 | 1 | 1 |
| rs267606619 | rs267606619 | 1 | 1 |
| rs4673993 | rs4673993 | 1 | 1 |
| rs1051266 | rs1051266 | 1 | 1 |
| rs2242480 | rs2242480 | 1 | 1 |
| rs11881222 | rs11881222 | 1 | 1 |
| rs115545701 | rs115545701 | 1 | 1 |
| rs1188934 | rs1188934 | 1 | 1 |
| rs10919563 | rs10919563 | 1 | 1 |
| rs3087243 | rs3087243 | 1 | 1 |
| rs1980422 | rs1980422 | 1 | 1 |
| rs10499194 | rs10499194 | 1 | 1 |
| rs629326 | rs629326 | 1 | 1 |
| rs6859219 | rs6859219 | 1 | 1 |
| rs11586238 | rs11586238 | 1 | 1 |
| R101H | R101H | 1 | 1 |
| Y244X | Y244X | 1 | 1 |
| rs2292832 | rs2292832 | 1 | 1 |
| rs3746444 | rs3746444 | 1 | 1 |
| rs11614913 | rs11614913 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Pyrazole in drug development: a medicinal-chemistry based analysis of USFDA-approved drugs in last decade.Molecular diversity1 mentions
- 2026Unlocking potentials of a prenylated flavonoid: Xanthohumol's role in combating inflammatory conditions and Rhematic diseases.Cytokine1 mentions
- 2026Platelet-derived non-coding RNAs as emerging contributors to autoimmune inflammation.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Untargeted metabolomics reveals immune-metabolic signatures in established cases of rheumatoid arthritis.Frontiers in molecular biosciences1 mentions
- 2026Hyaluronic acid microneedle patch for transdermal delivery of naringin-loaded PEGylated terpesomes in a rat model of rheumatoid arthritis: Modulation TGF-β1, oxidative stress, and inflammation.International journal of pharmaceutics: X1 mentions
- 2026Marine algal TNF-α inhibitors explored by comparative docking and molecular dynamics simulations.Computational biology and chemistry1 mentions
- 2026Epigenetic Alterations in Microbiome-Host Interactions in Inflammatory and Autoimmune Diseases.International journal of molecular sciences1 mentions
- 2026Seropositive rheumatoid arthritis with concomitant MRI confirmed sacroiliitis in an 18-year-old Saudi female: A case report of diagnostic and therapeutic challenges.Medicine1 mentions
- 2026A Review of Curcumin in Chronic Disease Management: Anti-Inflammatory Pathways, Antioxidant Activity, and Therapeutic Advances.Journal of nutrition and metabolism1 mentions
- 2026Therapeutic Potential of Bee Venom and Capsicum annum Hydroethanolic Extract in Experimental Model of Rheumatoid Arthritis in Male Rats.Mediators of inflammation1 mentions
- 2026Integrative Approaches to Gut Microbiota: Biomarkers, Dysbiosis, and Therapeutic Potential.Saudi medical journal1 mentions
- 2026Comprehensive bioinformatic and experimental approaches to analyze miR-200a, miR-1, and miR-548-3p expression and their targeted oxidative stress and glucose metabolic related hub genes in rheumatoid arthritis.Immunobiology1 mentions
- 2026Suspected Adult-Onset Congenital Myasthenic Syndrome Associated With a Heterozygous CHRND Variant in a Patient With Seropositive Rheumatoid Arthritis: A Case Report.The American journal of case reports1 mentions
- 2026Cordia myxa abrogates rheumatoid synoviocytes through inhibiting inflammatory responses and expression profiles of the TNF-α and COX-2 signaling pathway in a rodent model.Tissue & cell1 mentions
- 2025Recent Advances in Drug Delivery Approaches for Rheumatoid Arthritis.Current medicinal chemistry1 mentions
- 2025Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecular mechanisms.Critical reviews in microbiology1 mentions
- 2025Effects of Fisetin and Nicorandil on adjuvant-induced rheumatoid arthritis in rats: Emerging role of TLR4/NF-κB-induced Pyroptosis, Nrf-2/HO-1, and OPG/RANKL pathways.Cytokine1 mentions
- 2025Exploring Anticitrullinated Antibodies (ACPAs) and Serum-Derived Exosomes Cargoes.Antibodies (Basel, Switzerland)1 mentions
- 2025Glucose metabolism is controlled by non-coding RNAs in autoimmune diseases; a glimpse into immune system dysregulation.Human immunology1 mentions
- 2025Glucose transporter-1 (GLUT-1) upregulation in vitiligo: A possible link to skin depigmentation.Gene1 mentions
- 2025The multifaceted role of CS1 (SLAMF7) in immunoregulation: Implications for cancer therapy and autoimmune disorders.Experimental cell research1 mentions
- 2025Therapeutic effects of a femtosecond laser on rheumatoid arthritis in rats: Attenuation of oxidative stress and inflammation.Journal of photochemistry and photobiology. B, Biology1 mentions
- 2025Flavonoids and their role in oxidative stress, inflammation, and human diseases.Chemico-biological interactions1 mentions
- 2025Clinical Progress in Mesenchymal Stem Cell Therapy: A Focus on Rheumatic Diseases.Immunity, inflammation and disease1 mentions
- 2025Unveiling the heritability of selected unexplored pharmacogenetic markers in the Saudi population.Frontiers in pharmacology1 mentions
- 2025Cannabidiol as an immune modulator: A comprehensive review.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2025Impact of Pharmacological Treatments on Rheumatoid Arthritis-Associated Diffuse Interstitial Lung Disease: A Systematic Review and Meta-Analysis.Journal of personalized medicine1 mentions
- 2025Integrative proteo-metabolomic analysis in rheumatoid arthritis reveals potential therapeutic targets: Harnessing Mendelian randomization.Journal of pharmaceutical and biomedical analysis1 mentions
- 2025Polymorphism Analysis as Biomarker in Genes AIRE, CD40, HLA-DRB1 and TRAF1/C5 SNPs in Rheumatoid Arthritis Patients.International journal of immunogenetics1 mentions
- 2025Association of SLCO1B3 and SLCO1B1 Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2025Integrative molecular network analysis of genetic risk factors to infer biomarkers and therapeutic targets for rheumatoid arthritis.PloS one1 mentions
- 2025The impact of alpha-lipoic acid treatment on various mediators of inflammatory and immune responses in a murine arthritis model.Inflammopharmacology1 mentions
- 2025Advanced glycation end products (AGEs) and their role in diabetes mellitus and related complications: mechanisms and therapeutic insights.Glycoconjugate journal1 mentions
- 2025Association of ABCG2 Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2025Leukemias in the Context of Rheumatoid Arthritis: Shared Pathways and Clinical Perspectives.Cureus1 mentions
- 2025The Oral-Gut-Systemic Axis: Emerging Insights into Periodontitis, Microbiota Dysbiosis, and Systemic Disease Interplay.Diagnostics (Basel, Switzerland)1 mentions
- 2025Exploring genetic linkage between rheumatoid arthritis and systemic lupus erythematosus through biological networks and prioritizing omega-3 fatty acids as a potent therapeutic.Allergologia et immunopathologia1 mentions
- 2025Exploring the role of genetic variants in susceptibility to autoimmune Diseases: A molecular genetics approach.Human immunology1 mentions
- 2025Bioinformatics analysis of Rickettsia typhi autoimmune associations and screening of Streptomyces-derived inhibitors.BioData mining1 mentions
- 2025CD209 gene polymorphism and its clinical correlation with susceptibility to rheumatoid arthritis among Egyptian patients: A case-control study.Rheumatology and immunology research1 mentions
- 2024Mesenchymal Stem Cells and Curcumin Effectively Mitigate Freund's Adjuvant- induced Arthritis via their Anti-inflammatory and Gene Expression of COX-1, IL-6 and IL-4.Endocrine, metabolic & immune disorders drug targets1 mentions
- 2024Bridging autoimmunity and epigenetics: The influence of lncRNA MALAT1.Pathology, research and practice1 mentions
- 2024Leflunomide-induced cardiac injury in adult male mice and bioinformatic approach identifying Nrf2/NF-κb signaling interplay.Toxicology mechanisms and methods1 mentions
- 2024Potential clinical implications of molecular mimicry-induced autoimmunity.Immunity, inflammation and disease1 mentions
- 2024Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors.Journal of inflammation research1 mentions
- 2024The risk of tuberculosis infection in Saudi patients receiving adalimumab, etanercept, and tocilizumab therapy.Journal of infection and public health1 mentions
- 2024Integrating Network Pharmacology and Molecular Docking Approach to Elucidate the Mechanism of Commiphora wightii for the Treatment of Rheumatoid Arthritis.Bioinformatics and biology insights1 mentions
- 2024Recent advances in the therapeutic applications of selenium nanoparticles.Molecular biology reports1 mentions
- 2024Prevalence of Autoimmune Diseases Among Patients With Psoriasis: A Single Tertiary Center Experience.Cureus1 mentions
- 2024Deciphering the therapeutic potential of trimetazidine in rheumatoid arthritis via targeting mi-RNA128a, TLR4 signaling pathway, and adenosine-induced FADD-microvesicular shedding: In vivo and in silico study.Frontiers in pharmacology1 mentions
- 2024Adalimumab induced psoriasis in a Crohn's disease patient: A case report.JPMA. The Journal of the Pakistan Medical Association1 mentions
- 2024Down-regulation of NF-κB signalling by methanolic extract of Viola odorata (L.) attenuated in vivo inflammatory and angiogenic responses.Inflammopharmacology1 mentions
- 2024Autoantibodies Serum Level and 10-Year Risk of Fractures Evaluated by FRAX® Tool in Rheumatoid Arthritis Patients.Open access rheumatology : research and reviews1 mentions
- 2024Incidence Rate of Cardiovascular Events in Rheumatoid Arthritis: An Observational Cohort Study in Saudi Arabia.Journal of multidisciplinary healthcare1 mentions
- 2024Interferon-induced protein 44 (IFI44) and interferon regulatory factor 4 (IRF4) gene expression in rheumatoid arthritis.Journal of immunoassay & immunochemistry1 mentions
- 2024Small molecule and big function: MicroRNA-mediated apoptosis in rheumatoid arthritis.Pathology, research and practice1 mentions
- 2024In vitro Assessment of the Effects of Host Modulatory Agents on Osteoclastogenesis.Journal of pharmacy & bioallied sciences1 mentions
- 2024Demographic and clinical associations of autoimmune diseases in rheumatoid arthritis patients: Insights from a tertiary care hospital in Saudi Arabia from 2019 to 2023.SAGE open medicine1 mentions
- 2024Navel orange peel ethanolic extract and naringin ameliorate CFA-induced arthritis in Wistar rats through their modulatory effects on Th1/Th2/Th17 cytokines and oxidative stress.American journal of translational research1 mentions
- 2024Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms.Microbial pathogenesis1 mentions
- 2023Prevalence of apical periodontitis in patients with autoimmune diseases: A case-control study.International endodontic journal1 mentions
- 2023Gum-gut axis: The potential role of salivary biomarkers in the diagnosis and monitoring progress of inflammatory bowel diseases.The Saudi dental journal1 mentions
- 2023MIR149 rs2292832 and MIR499 rs3746444 Genetic Variants Associated with the Risk of Rheumatoid Arthritis.Genes1 mentions
- 2023Public awareness about arthritic diseases in Saudi Arabia: a systematic review and meta-analysis.International orthopaedics1 mentions
- 2023The molecular mechanisms underlying anti-inflammatory effects of galangin in different diseases.Phytotherapy research : PTR1 mentions
- 2023Current trends in epigenetic, cellular and molecular pathways in management of rheumatoid arthritis.Inflammopharmacology1 mentions
- 2023Certolizumab to treat hidradenitis suppurativa.Dermatology reports1 mentions
- 2023Association of Human Leukocyte Antigen (HLA) class II (DRB1 and DQB1) alleles and haplotypes with Rheumatoid Arthritis in Sudanese patients.Frontiers in immunology1 mentions
- 2023Exploring the impact of miR-128 in inflammatory diseases: A comprehensive study on autoimmune diseases.Pathology, research and practice1 mentions
- 2023Association of CYP2C9∗3 and CYP2C8∗3 Non-Functional Alleles with Ibuprofen-Induced Upper Gastrointestinal Toxicity in a Saudi Patient.Case reports in medicine1 mentions
- 2023Advanced glycation end product signaling and metabolic complications: Dietary approach.World journal of diabetes1 mentions
- 2023Rituximab alleviates increased disomic sperm in DBA/1J mouse models of rheumatoid arthritis via restoration of redox imbalance.Journal of biochemical and molecular toxicology1 mentions
- 2023Single Nucleotide Polymorphisms Associated with Rheumatoid Arthritis in Saudi Patients.Journal of clinical medicine1 mentions
- 2023New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function.Annals of the rheumatic diseases1 mentions
- 2023Highly Biocompatible Smart Injectable Hydrogel for the Management of Rheumatoid Arthritis.ACS biomaterials science & engineering1 mentions
- 2023Impact of glycogen synthase kinase-3ß inhibition on rats' temporomandibular joint collagen-induced rheumatoid arthritis with correlation to miRNA-155/miRNA-24 expression.European review for medical and pharmacological sciences1 mentions
- 2023Investigation of VEGF (rs 699947) polymorphism in the progression of Rheumatoid Arthritis (RA) and in-silico nanoparticle drug delivery of potential phytochemicals to cure RA.Acta biochimica Polonica1 mentions
- 2023Red Blood Cell Distribution Width: A Potential Inexpensive Marker for Disease Activity in Patients with Rheumatic Diseases; Scoping Review.Open access rheumatology : research and reviews1 mentions
- 2023Homocysteine as a predictor and prognostic marker of atherosclerotic cardiovascular disease: a systematic review and meta-analysis.European review for medical and pharmacological sciences1 mentions
- 2023Targeting CD44 Receptor Pathways in Degenerative Joint Diseases: Involvement of Proteoglycan-4 (PRG4).Pharmaceuticals (Basel, Switzerland)1 mentions
- 2023Identification of novel STAT3 inhibitors for liver fibrosis, using pharmacophore-based virtual screening, molecular docking, and biomolecular dynamics simulations.Scientific reports1 mentions
- 2023Prevalence and Characteristics of Knee Osteoarthritis Among the General Public in Saudi Arabia.Cureus1 mentions
- 2023Pregnancy and Inflammatory Rheumatological Diseases: A Single-Center Retrospective Cohort Study.Cureus1 mentions
- 2023Correlation of anti-TNF-a biological therapy with periodontal conditions and osteonecrosis in autoimmune patients: A systematic review.The Saudi dental journal1 mentions
- 2023Alkaptonuria in an Elderly Presenting with Asynchronous Rupture of both Quadriceps Tendons and Chronic Kidney Failure: Case Report and Literature Review.Journal of orthopaedic case reports1 mentions
- 2023Phytochemical characterization and anti-arthritic potential of Croton bonplandianus leaves extract: In-vivo and in-silico approach.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2022Interplay of Microbiota and Citrullination in the Immunopathogenesis of Rheumatoid Arthritis.Probiotics and antimicrobial proteins1 mentions
- 2022DNA methylation across the tree of life, from micro to macro-organism.Bioengineered1 mentions
- 2022Rheumatologic diseases in patients with inborn errors of immunity in the USIDNET registry.Clinical rheumatology1 mentions
- 2022A CD40 variant is associated with systemic bone loss among patients with rheumatoid arthritis.Clinical rheumatology1 mentions
- 2022Application of extracellular vesicles derived from mesenchymal stem cells as potential therapeutic tools in autoimmune and rheumatic diseases.International immunopharmacology1 mentions
- 2022Novel functional polymorphism on PADI-4 gene and its association with arthritis onset.Saudi journal of biological sciences1 mentions
- 2022Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases.Stem cell research & therapy1 mentions
- 2022A Rare Case of Didanosine-Induced Mid-Peripheral Chorioretinal Atrophy Identified Incidentally 11 Years after the Drug Cessation.Medicina (Kaunas, Lithuania)1 mentions
- 2022Deep Learning and Structure-Based Virtual Screening for Drug Discovery against NEK7: A Novel Target for the Treatment of Cancer.Molecules (Basel, Switzerland)1 mentions
- 2022Exploring the pivotal role of endothelin in rheumatoid arthritis.Inflammopharmacology1 mentions
- 2022Effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney.Inflammopharmacology1 mentions
- 2022Prolonged COVID-19 symptom duration in people with systemic autoimmune rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey.RMD open1 mentions
- 2022Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.Nature genetics1 mentions
- 2022Pancreatic Pathological Changes in Murine Toxoplasmosis and Possible Association with Diabetes Mellitus.Biomedicines1 mentions