FOXO1
HGNC:3819 · 25 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FOXO1 | “Presentations highlighted molecularly driven diagnostics such as FOXO1 fusion testing in rhabdomyosarcoma and LOGIC assays for constitutional mismatch repair deficiency, with emphasis on affordable applications in low- and middle-income countries (LMICs).” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Additional investigations revealed that PP902 supplementation reduced DEX-induced FOXO1 activity and enhanced p-FoxO1 and Akt activation.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Moreover, we constructed a miRNA-mRNA regulatory network to visualize the functions of miRNAs related to IMF deposition in the yak. miR-122, miR-375, and miR-378 may play a key role in IMF deposition in the yak, and RORC, STAT3, ACACA, FTO, and FOXO1 were the core target genes.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “FOXO1 (forkhead box protein O1), a key substrate of sirt1, is a transcription factor that controls the expression of genes involved in a wide range of cellular processes.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Multiple targets such as SIRT3, FOXO1, PRKAA1, PPARGC1A, and CREBBP directly regulate reactive oxygen species levels and oxidative stress, suggesting that targeting these genes could help prevent further cellular damage.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “High glucose stimulation of Neuro2a cells increased PARP1 expression, and with siRNA-ChNP (1:3000) treatment, significant inhibition of PARP1 expression is observed that consequently reversed the expression of regulatory genes like SIRT1, FOXO1, FOXO3, and p53.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Our analysis revealed that hsa-miR-320a-3p and its key targets, including PTEN, AKT1, BCL2, FOXO1 and MYC, are dysregulated in T1D, along with their interacting partners namely BLIMP3, GSK3B, CAV1, CXCL3, TGFB, and IL10.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Among the 25 proteins, the highest modulated genes and highest binding affinity were exhibited by SIRT3, FOXO1, and PPARGC1A with the compound IMPHY000797.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Chitosan/hesperidin nanoparticles formulation: a promising approach against ethanol-induced gastric ulcers via Sirt1/FOXO1/PGC-1α/HO-1 pathway.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “We discovered 73 common DEGs (CDEGs) and ten HubGs (ATAD2B, PPP1CB, FOXO1, AKT3, BCR, PDE4D, ITGB1, PCBP2, CD44 and SMARCA2).” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “We tested the hypothesis that FOXO1 plays a key role in diabetes-impaired angiogenesis and chondrocyte apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “FOXO1 and PAX5 Rearrangement in Alveolar Rhabdomyosarcoma in Saudi Pediatric Patients.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “The Value of SIRT1/FOXO1 Signaling Pathway in Early Detection of Cardiovascular Risk in Children with β-Thalassemia Major.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Recently miRNAs were also identified to act either as oncogenes or tumor suppressors in DLBCL pathology by altering the expression levels of some of the known DLBCL related oncogenes. i.e., miR-155, miR-17-92 and miR-21 act as oncogenes by altering the expression levels of MYC, SHIP and FOXO1, respectively, conversely; miR-34a, mir-144 and miR-181a act as tumor suppressors by altering the expression levels of SIRT1, BCL6 and CARD11, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “These events were associated with increased deacetylase activity and total levels of SIRT1 and a parallel decrease in the acetylation of Nrf2, NF-κB, smad2, and FOXO1.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “FOXO1 expression in chondrocytes modulates cartilage production and removal in fracture healing.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Of note, EA increased the expression and activity of SIRT1 and suppressed the acetylation of nuclear factor erythroid-derived 2-like 2 (Nrf2), nuclear factor kappa B (NF-κB), smad2, and forkhead box, class O (FOXO1) in the LVs of both the control and diabetic groups.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Deletion of FOXO1 in chondrocytes rescues the effect of diabetes on mechanical strength in fracture healing.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “In agreement, clonogenic cytotoxic assays using wild-type and foxo1/3/4-/- mouse embryonic fibroblasts (MEFs) showed that FOXO1/3/4-deletion significantly attenuates Lapatinib-induced cytotoxicity, confirming that FOXO proteins are essential for mediating Lapatinib response.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “We examined the role of chondrocytes in angiogenesis during fracture healing and the role of the transcription factor forkhead box-O 1 (FOXO1), which upregulates wound healing in soft tissue.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Role of Overexpressed Transcription Factor FOXO1 in Fatal Cardiovascular Septal Defects in Patau Syndrome: Molecular and Therapeutic Strategies.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “FOXO1 gene is highly expressed in adipose tissues and it affects the regulation of glycogenolysis and gluconeogenesis through insulin signaling.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “FOXO1 Deletion Reverses the Effect of Diabetic-Induced Impaired Fracture Healing.” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “Semi-quantitative reverse transcriptase PCR analysis and quantitative fold change analysis of the fresh liver biopsies of eight chronically infected HCV-3 patients and six healthy individuals were evaluated for three potential biomarkers involved in glucose homeostasis induction, namely mitochondrial phosphoenolpyruvate carboxykinase 2 (PCK2), glucose-6-phosphatase catalytic subunit (G6PC) and associated forkhead box protein 01 (FOXO1).” | 0.98 | hgnc_dict_v1 |
| gene | FOXO1 | “In vitro apoptosis and proliferation were examined in C3H10T1/2 and human-bone-marrow-derived MSCs following transfection with FOXO1 small interfering (si)RNA.” | 0.98 | hgnc_dict_v1 |