GSTT1
HGNC:4641 · 36 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GSTT1 | “Specifically, regarding the GSTT1 genotype, individuals with the GSTT1-null genotype had an odds ratio (OR) of 4.16 and a relative risk (RR) of 2.14 compared to those with the GSTT1 genotype, with statistically significant differences (p = 0.0001).” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “The incidence of ischemic stroke is probably increased by the interaction of GSTT1 and GSTM1 null genotypes with high blood pressure, diabetes and cigarette smoking.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Chronic exposure to electronic waste poses risk to liver toxicity with molecular interaction of GSTM1, GSTT1 null variants, and GSTP1.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Impact of GSTT1 and GSTM1 Polymorphisms in the Susceptibility to Philadelphia Negative Chronic Myeloid Leukaemia.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “The current study aimed to investigate the relationship between polymorphisms in detoxifying (GSTM1, GSTT1, and GSTP1) genes and their association with colorectal cancer (CRC) in tobacco addicts of Pashtun ethnicity.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Glutathione S-transferase (GSTT1) is involved in activation of detoxification reactions and catalysis of chemicals conjugation with glutathione.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “PURPOSE: Glutathione S-transferases (GSTT1 and GSTM1) detoxify various endogenous and exogenous compounds and provide cytoprotective role against reactive species.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “GSTT1 null (HR = 0.39, 95%CI: 0.18-0.84, P = 0.017) genotype has better response to chemotherapy.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “PURPOSE: This study aims to evaluate the association between polymorphisms in antioxidant enzyme-encoding genes: catalase (CAT); manganese superoxide dismutase (Mn-SOD); glutathione S transferase M1 (GSTM1); and GSTT1 glutathione S transferase T1 (GSTT1), and the risk of type II diabetic nephropathy (DN) in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “In addition, many of the serum pollutants were significantly associated with GSTT1, GSTM1 (null/present polymorphism) and presented the genotypic variation to respond xenobiotics in children.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Materials & methods: Asthma patients (n = 250) and age-matched healthy subjects (n = 250) DNA were genotyped for GSTM1/GSTT1 (+/+, +/-, -/+ and -/-) frequencies using multiplex-PCR and plasma oxidative stress markers (examined spectrophotometrically).” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “GSTT1 null and rs156697 Polymorphism in GSTO2 Influence the Risk and Therapeutic Outcome of B-Acute Lymphoblastic Leukemia Patients.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “We explored whether allelic variants of the GSTM1, GSTT1, CYP450 (rs4646903 and rs1048943), and TP53 (rs1042522) genes predisposed nonsmoking Saudi individuals to increased risk for CRC.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Glutathione S-Transferase (GSTT1 rs17856199) and Nitric Oxide Synthase (NOS2 rs2297518) Genotype Combination as Potential Oxidative Stress-Related Molecular Markers for Type 2 Diabetes Mellitus.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “RESULTS: GSTT1, GSTO1, and GSTO2 SNPs revealed no association, while as GSTM1null genotype was observed to protect against the development of CML (OR = 0.53, P = .01).” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Combined GSTT1 Null, GSTM1 Null and XPD Lys/Lys Genetic Polymorphisms and Their Association with Increased Risk of Chronic Myeloid Leukemia.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Genetic Polymorphism of GSTP1, GSTM1 and GSTT1 Genes and Susceptibility to Chronic Myeloid Leukaemia.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “In the GST gene, GSTM1 and GSTT1 variants were genotyped by multiplex PCR, and GSTP1 variants were genotyped by PCR-RFLP analysis.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Association Of GSTM1, GSTT1 And GSTP1 Polymorphisms With Breast Cancer Among Jordanian Women.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “The aim of the current study is to investigate the association between GSTT1 and GSTM1 polymorphisms and chronic myeloid leukemia (CML) among Sudanese patients.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Of the five polymorphisms studied, GSTT1 (OR: 1.07, 95% CI: 1.02-1.12 and OR: 1.08, 95% CI: 1.01-1.15 for fixed-effect and random-effect models, respectively) and GSTM1 (OR: 1.22, 95% CI: 1.17-1.26 and OR: 1.25, 95% CI: 1.12-1.35 for fixed-effect and random-effect models, respectively) null polymorphisms exhibited an increased risk for breast cancer in both the models.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “This model depicted hypertension and alcohol intake as the key predictors of CAD risk followed by cSHMT C1420T, GCPII C1561T, diabetes, GSTT1, CYP1A1 m2, TYMs 5'-UTR 28 bp tandem repeat and MTRR A66G.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Genomic DNA was taken from buccal cells of 52 patients with UBC and 104 controls for genotyping of GSTT1, GSTM1, rs4646903, rs1048943, TP53 rs1042522, rs1801133, and rs1801394 using PCR and TaqMan® assays.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “The objective of our study was to evaluate the oxidative stress profile caused by IR in 29 Tunisian medical staff from radiology and radiotherapy departments, and to find an association between the GSTM1 null, GSTT1 null, and GSTP1 Ile105Val polymorphisms and oxidative stress biomarkers.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “We identified frequent (present at least in 10% of patients) alterations including three macro-alteration at 8p23.1, 10q11.21-q11.22 and 15q11.2 as well as large numbers of micro-deletions/amplifications with affected genes including 22q11.23 (GSTT1), 3p22.2 (CTDSPL), 6p21.32 (HLA), and 8p22 (MSR1).” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “The aim of the study was to evaluate the genetic association of GSTM1 and GSTT1 gene deletion/null polymorphism with disease susceptibility and risk development in CRC patients of ethnic Kashmiri population.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Association of glutathione S-transferase GSTM1 and GSTT1 deletion polymorphisms with obesity and their relationship with body mass index, lipoprotein and hypertension among young age Saudis.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “The frequencies of homozygous GSTM1 and GSTT1 deletion carriers are very high in most of the populations studied to date.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “METHODS: 223 incident papillary thyroid cancer cases and 513 controls recruited from Saudi Arabian population were analyzed for the association between polymorphisms in genes encoding folic acid metabolizing enzymes MTHFR and six xenobiotics-metabolizing enzymes including CYP1A1 T3801C, C4887A, GSTP1 A1578G, C2293T, GSTM1, GSTT1, NAT2 G590A, NQO*1 C609T, using PCR-RELP.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Polymorphisms in five genes (CYP1A1, GSTT1, GSTP1, GSTM1, and NQO1) were characterized in 182 individuals with DLBCL and 513 normal controls using PCR-RFLP method.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “In humans, GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) are associated with a variety of pathologic processes including certain ophthalmologic diseases.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “BACKGROUND: The association of the deletion in GSTT1 and GSTM1 genes with coronary artery disease (CAD) among smokers is controversial.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “The frequencies of alleles and/or genotypes for CYP1A1*2A, GSTT1 null, GSTT1 and GSTM1 double null, and GSTP1 A1578G in Arabs were significantly higher than those reported in Caucasians.” | 0.98 | hgnc_dict_v1 |