MYC
HGNC:7553 · 27 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MYC | “Functional analysis of ARR, MYC, and FLS genes in alfalfa under salt stress using Agrobacterium rhizogenes-mediated composite plants.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “To further explore STAT1‑associated functional effect, we conducted pathway analyses for the IFN‑γ response and MYC‑driven proliferative pathway using the Hallmark gene sets "INTERFERON_GAMMA_RESPONSE" and "MYC_TARGETS_V1," respectively.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Moreover, it can inhibit inflammatory markers (IL-6, TNF-α, and IL-1β), downregulate oncogenes (Ras, HER2, MYC, and BCR/ABL1), and upregulate tumor suppressor genes (TSGs) such as TP53, PTEN, and BRCA1 and BRCA2 expression.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Further analysis revealed that applying of B. velezensis VB7 activated strong immune responses in tomato plants, significantly induced MAMP-triggered immunity via the expression of various transcription factors/defense genes by several folds to MAPK, NPR1, PAD1, MYC, and CAT in comparison to those RKN-inoculated and healthy control through qRT-PCR.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Trophoblast cells were passaged three times using feeder-free culture conditions and immunofluorescence analysis confirmed the expression of key trophoblast markers including CDX2, GATA3, syncytin-1, β-catenin, SOX2, Fascin, SOX9, BMP4, MYC, KRT7, and KRT18.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “This review highlights key molecular pathways involved in oncogenesis, focusing on genetic alterations (mutations, amplifications, and translocations) in oncogenes (RAS and MYC) and tumor suppressor genes (TP53 and PTEN).” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Moreover, anthocyanins downregulate oncogenes (Bcl-2, MYC, and HER2) and improve the activity of tumor suppressor genes (TP53, BRCA1, and RB1).” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “This work corroborates previous studies, showing significant enrichment of MYC activity and heme metabolism in SF3B1 mutant cells.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Immunohistochemistry was positive for GATA3 in the tumor cells, and next generation sequencing revealed CDC73 mutation, MYC rearrangement, ASXL1 mutation, and a tumor mutational burden (TMB) of 11 Muts/Mb.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “An in-silico analysis identified the dysregulation of several critical genes AXIN2, MYC, TEAD4, MET, LPAR1, and ADCY9 in colorectal cancer, highlighting their involvement in the Hippo and Rap1 signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Furthermore, CNVs in the MYC and PTEN genes were observed in 15% and 10% of the patients, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Ag NPs also upregulated the hepatic and renal genes involved in inflammation such as the interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α), nuclear factor kappa B (nf-κβ), apoptosis such as the BCL2 associated X (bax), casp3, and other related to metabolism including asparagine synthetase (asns), suppressor of cytokine signaling 3 (socs3), MYC proto-oncogene (myc), and C-C motif chemokine ligand 2 (ccl2).” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Genetic investigations, led by high-throughput sequencing, have unveiled recurrent mutations in genes such as MYC, BCL2, and BCL6, casting light on the underlying genetic chaos propelling DLBCL's aggressiveness.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Wnt/β-catenin target genes (MYC, MYB, and RUNX1) showed upregulation, while Wnt/β-catenin inhibitors (CXXR, DKK1-4, SFRP1-4, SOST, and WIFI) were suppressed in elderly AML compared to pediatric AML and controls.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “TLR4 activation in turn caused c-JUN-dependent and STAT3-dependent translocations of MYC loci to suppress transactivation of CD95/FAS.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “We also find that ADCY8, MYC, PTK2, CTNNB1, TP53, RB1, PRKCA, TCF7L2, PAK1, ITPR2, CYP3A4, UGT1A6, GCK, and FGFR2/3 appear to be among the prominent genes based on the networks of genes and pathways based on the copy number alterations, mutations, and structural variants study.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “The key genes, including EGFR, MYC, VEGFA, and PTEN, are targeted by TF such as AR, Sp1, TP53, NF-KB1, STAT3, RELA.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “CONCLUSION: Based on our study, we conclude that the potential genes which are affected due to infection are NFKBIA, MYC, FOXO3, BIRC3, ICAM1, IL8, CXCL1/2/5, GADD45A, RELB, SGK1, AREG, BBC3, DDIT3/4, EGR1, MTHFD2, and SESN2 and the functional changes are mainly associated with these pathways: TNF, cytokine, NF-kB, TLR, TCR, BCR, Foxo, and TGF signaling pathways are among them and there are additional pathways such as hippo signaling, apoptosis, estrogen signaling, regulating pluropotency of stem cells, ErbB, Wnt, p53, cAMP, MAPK, PI3K-AKT, oxidative phosphorylation, protein processing in endoplasmic reticulum, prolactin signaling, adipocytokine, neurotrophine signaling, and longevity regulating pathways.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Promoter analysis revealed the presence of diverse cis-regulatory elements among which CAAT box, MYB, MYC, unnamed-4 were common to all of them.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Recently miRNAs were also identified to act either as oncogenes or tumor suppressors in DLBCL pathology by altering the expression levels of some of the known DLBCL related oncogenes. i.e., miR-155, miR-17-92 and miR-21 act as oncogenes by altering the expression levels of MYC, SHIP and FOXO1, respectively, conversely; miR-34a, mir-144 and miR-181a act as tumor suppressors by altering the expression levels of SIRT1, BCL6 and CARD11, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Out of these 10 modules that consist of 19 key genes (11 downregulated and 8 up-regulated), Module 1 (RPL13, RPLP0, RPS24, and RPS2) and module 5 (MYC, COX7B, and SOCS3) had the highest number of these genes.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Network construction ultimately lead to the identification of nine gene named FN1, EGR1, FOS, JUN, SERPINE1, MMP2, ATF3, MYC, and IL1B and one novel key miRNA namely, has-miR-144-3p as biomarker for diagnosis and therapy of IgAN.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “BACKGROUND: Colorectal cancer (CRC) is categorized by alteration of vital pathways such as β-catenin (CTNNB1) mutations, WNT signaling activation, tumor protein 53 (TP53) inactivation, BRAF, Adenomatous polyposis coli (APC) inactivation, KRAS, dysregulation of epithelial to mesenchymal transition (EMT) genes, MYC amplification, etc.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Carter O17 Recurrent somatic mutation in the MYC associated factor X in brain tumors H.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Moreover, MLLT1-mutant tumours show an increase in MYC gene expression and HOX dysregulation.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Protein expression from MYC and HMGA2 was elevated when HPV integrated into flanking regions.” | 0.98 | hgnc_dict_v1 |
| gene | MYC | “Amplification of the two oncogenes ERBB2 and MYC and deletion of the tumor suppressor gene TP53 are frequently encountered in cancerous tissues.” | 0.98 | hgnc_dict_v1 |