sickle cell anemia
HP:0001878 · 603903 · SaudiVarKB evidence summary derived from retained literature mentions.
330Phenotype mentions
100Publications
21Associated gene records
18Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| G6PD | HGNC:4057 | 8 | 8 |
| HBB | HGNC:4827 | 7 | 7 |
| BCL11A | HGNC:13221 | 6 | 6 |
| CRP | HGNC:2367 | 2 | 2 |
| IMPACT | HGNC:20387 | 2 | 2 |
| ANTXR1 | HGNC:21014 | 2 | 2 |
| SIRT1 | HGNC:14929 | 1 | 1 |
| NLRP3 | HGNC:16400 | 1 | 1 |
| CD34 | HGNC:1662 | 1 | 1 |
| KLF1 | HGNC:6345 | 1 | 1 |
| CD19 | HGNC:1633 | 1 | 1 |
| MYH9 | HGNC:7579 | 1 | 1 |
| HMOX1 | HGNC:5013 | 1 | 1 |
| PGD | HGNC:8891 | 1 | 1 |
| CCR5 | HGNC:1606 | 1 | 1 |
| LIN28A | HGNC:15986 | 1 | 1 |
| BCL7A | HGNC:1004 | 1 | 1 |
| BCL2L1 | HGNC:992 | 1 | 1 |
| KLF6 | HGNC:2235 | 1 | 1 |
| GATA6 | HGNC:4174 | 1 | 1 |
| ZBTB7A | HGNC:18078 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| rs333 | rs333 | 1 | 1 |
| rs3834466 | rs3834466 | 1 | 1 |
| rs28440105 | rs28440105 | 1 | 1 |
| rs10128556 | rs10128556 | 1 | 1 |
| rs968857 | rs968857 | 1 | 1 |
| rs2071746 | rs2071746 | 1 | 1 |
| rs4527238 | rs4527238 | 1 | 1 |
| rs35685045 | rs35685045 | 1 | 1 |
| rs1427407 | rs1427407 | 1 | 1 |
| rs6706648 | rs6706648 | 1 | 1 |
| rs6738440 | rs6738440 | 1 | 1 |
| rs7606173 | rs7606173 | 1 | 1 |
| c.364G>A | c.364G>A | 1 | 1 |
| p.Glu122Lys | p.Glu122Lys | 1 | 1 |
| rs4671393 | rs4671393 | 1 | 1 |
| rs1427407 | rs1427407 | 1 | 1 |
| rs9399137 | rs9399137 | 1 | 1 |
| rs28384513 | rs28384513 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Health-related quality of life and adherence to hydroxyurea in patients with sickle cell anemia in Saudi Arabia.Medicine1 mentions
- 2026Magnitude of Involvement of Peripheral Nervous System in Sickle Cell Anemia Patients in Vaso-Occlusive Crisis.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion1 mentions
- 2026Pyruvate Kinase Activators for Sickle Cell Disease: An Exploratory Systematic Review and Meta-Analysis.Hemoglobin1 mentions
- 2026Frequency of Alloimmunization in Patients on Regular Blood Transfusion in Riyadh, Saudi Arabia: A Multicenter Retrospective Study.Journal of clinical medicine1 mentions
- 2026Predictors of Critical Care Interventions and Length of Stay in Pediatric Sickle Cell Acute Chest Syndrome: A Five-Year Pediatric Intensive Care Unit (PICU) Cohort Study.Cureus1 mentions
- 2026Influenza A-Triggered Severe Acute Chest Syndrome in a Child With Sickle Cell Disease Complicated by Plastic Bronchitis and Posterior Reversible Encephalopathy Syndrome.Cureus1 mentions
- 2026Predictors of Cerebrovascular Accident Among Sudanese Children with Sickle Cell Anemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion1 mentions
- 2026Oral Radiographic Changes in Severe Sickle Cell Anemia Patients: A Retrospective Comparative Study.Clinical, cosmetic and investigational dentistry1 mentions
- 2026CRISPR and Fanzor in sickle cell disease: current progress and future prospects.Frontiers in genome editing1 mentions
- 2025The Direct Medical Costs of Sickle Cell Disease in Saudi Arabia: Insights from a Single Center Study.Healthcare (Basel, Switzerland)1 mentions
- 2025Evaluation of low-cost techniques to detect sickle cell disease and β-thalassemia: an open-label, international, multicentre study.The Lancet regional health. Southeast Asia1 mentions
- 2025The Prevalence and Predictors of Sickle Cell Anemia in the Saudi Arabia General Population: Findings from a Cross-Sectional Study.Healthcare (Basel, Switzerland)1 mentions
- 2025Fox-Fordyce Disease in Women: A Case Report Highlighting Laser-Based Interventions.Cureus1 mentions
- 2025The Economic Impact of Premarital Screening (PMS) of Sickle Cell Anemia on the Saudi Health System: A Cost Analysis Study.Healthcare (Basel, Switzerland)1 mentions
- 2025Non-Traumatic Fat Embolism Syndrome in Two HbSS Sickle Cell Disease Patients: A Case Series and Review.Journal of blood medicine1 mentions
- 2025Radiologic Evaluation of Paranasal Sinuses in Sickle Cell Anemia and Thalassemia: Case-Control Study.Laryngoscope investigative otolaryngology1 mentions
- 2025Therapeutic drug monitoring of busulfan in pediatric patients: a 5-year observational study.BMC pharmacology & toxicology1 mentions
- 2025Fulminant Pneumococcal Meningitis With Neurovascular Complications in an Adult With Sickle Cell Anemia: A Case Report.Cureus1 mentions
- 2025Genetic patterns & public health implications of sickle cell anaemia across populations: A systematic review.The Indian journal of medical research1 mentions
- 2025The Impact of Aging on Organ Systems in Sickle Cell Disease: a Comparative Review of Physiological Adaptation and Dysfunction.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology1 mentions
- 2024Plasminogen activator inhibitor-2 and impaired fibrinolysis in pregnancy and sickle cell anemia.Archives of gynecology and obstetrics1 mentions
- 2024CRISPR-Cas9 system: a novel and promising era of genotherapy for beta-hemoglobinopathies, hematological malignancy, and hemophilia.Annals of hematology1 mentions
- 2024Non-traumatic bilateral epidural hematoma in a child with sickle cell anemia: A case report and a review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery1 mentions
- 2024Successful Conservative Therapy for Infected Penile Implants: A Case Series.The American journal of case reports1 mentions
- 2024Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats.Toxicology1 mentions
- 2024Risk factors for acute chest syndrome among children with sickle cell anemia hospitalized for vaso-occlusive crises.Scientific reports1 mentions
- 2024A Saudi Woman with Ceftriaxone Induced Fixed Drug Eruption.Case reports in dermatological medicine1 mentions
- 2024Beyond pulmonary embolism: Alternative diagnosis and incidental findings on CT pulmonary angiography in sickle cell disease.Emergency radiology1 mentions
- 2024Knowledge, Attitude, Motivators, and Barriers to Blood Donation Among Adults in Al-Qunfudah Governorate, Saudi Arabia: A Cross-Sectional Study.Cureus1 mentions
- 2024Total Hip Arthroplasty Complications in Sickle Cell Disease: Systematic Review and Meta-Analysis.Journal of clinical medicine1 mentions
- 2024Targeted therapeutic management based on phytoconstituents for sickle cell anemia focusing on molecular mechanisms: Current trends and future perspectives.Phytomedicine : international journal of phytotherapy and phytopharmacology1 mentions
- 2024Genetic Patterns of Oral Cavity Microbiome in Patients with Sickle Cell Disease.International journal of molecular sciences1 mentions
- 2024Assessment of Burden on Family Caregivers of Children With Sickle Cell Anemia in Al Madinah Al Munawwarah, Saudi Arabia.Cureus1 mentions
- 2024Impaired phagocytosis and oxidative respiratory burst activity in sickle cell anemia leukocytes.Journal of Taibah University Medical Sciences1 mentions
- 2024Opioid Control for Patients With Sickle Cell Anemia in Emergency Departments in the Western Region of Saudi Arabia.Cureus1 mentions
- 2024Outcome of Pediatric Patients With Sickle Cell Anemia Admitted With Fever: A Retrospective Single-Center Study.Cureus1 mentions
- 2024Associations of haematological and inflammatory biomarkers with brain volume in patients with sickle cell anaemia: A cross-sectional retrospective study.Tropical medicine & international health : TM & IH1 mentions
- 2024Quality of Life and Out-of-Pocket Expenditures for Sickle Cell Disease Patients in Saudi Arabia: A Single-Center Study.Healthcare (Basel, Switzerland)1 mentions
- 2024Prevalence and classification of anemia among children in Sudan: a systematic review and meta-analysis.Journal of medicine and life1 mentions
- 2024Nationwide survey on awareness of consanguinity and genetic diseases in Saudi Arabia: challenges and potential solutions to reduce the national healthcare burden.Human genomics1 mentions
- 2023Impact of hydroxyurea on lymphocyte subsets in children with sickle cell anemia.Pediatric research1 mentions
- 2023Oral microbiota analyses of Saudi sickle cell anemics with dental caries.International dental journal1 mentions
- 2023The effect of different types of anemia on HbA1c levels in non-diabetics.BMC endocrine disorders1 mentions
- 2023Moyamoya syndrome secondary to mitochondrial disease in a patient with partial trisomy 13q14 and 13q31: A novel case report and literature review.Heliyon1 mentions
- 2023The Prevalence of Cardiovascular Manifestations in Pediatric Sickle Cell Anemia Patients in a Large Tertiary Care Hospital in the Western Region of Saudi Arabia.Cureus1 mentions
- 2023Outcomes of Cholelithiasis Among Patients With Sickle Cell Disease: A Tertiary Care Center Experience.Cureus1 mentions
- 2023The perception of pediatric sickle cell anemia patient's caregivers toward hematopoietic stem cell transplantation (single-center experience, Saudi Arabia).Frontiers in pediatrics1 mentions
- 2023Sickle cell anemia in pregnant Saudi women and its impact on birth weight and gestational maturity.Journal of the Chinese Medical Association : JCMA1 mentions
- 2023Molecular Detection of Hemoglobin O-Arab in the Sudanese Population.International journal of general medicine1 mentions
- 2023Assessing the Impact of COVID-19 Vaccines on Sickle Cell Anaemia Patients: A Comparative Analysis of Biochemical and Haematological Parameters.Biomedicines1 mentions
- 2023Therapeutic benefits of prophetic medicine remedies in treating hematological diseases (A review article).American journal of blood research1 mentions
- 2023Epidemiology of Glucose-6-Phosphate Dehydrogenase Deficiency in Arab Countries: Insights from a Systematic Review.Journal of clinical medicine1 mentions
- 2023Painless Orbital Bone Infarction in a Child with Sickle Cell Anemia: A Case of Misdiagnosed Periorbital Cellulitis.The American journal of case reports1 mentions
- 2023Multiple small bowel obstructions due to unusual formation of biliary phytobezoars following laparoscopic cholecystectomy in a sickler patient: A case report, an atypical surgical approach.International journal of surgery case reports1 mentions
- 2023Moyamoya Syndrome in Children With Sickle Cell Disease in Saudi Arabia: A Single-Center Experience.Cureus1 mentions
- 2023Frequency of Painful Crisis and Other Associated Complications of Sickle Cell Anemia Among Children.Cureus1 mentions
- 2023Renal outcomes in pediatric patients with sickle cell disease: a single center experience in Saudi Arabia.Frontiers in pediatrics1 mentions
- 2023Response to Lisinopril in Patients with Sickle Cell Anemia and Proteinuria.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia1 mentions
- 2022Telomere length and telomere repeat-binding protein in children with sickle cell disease.Pediatric research1 mentions
- 2022Prevalence of and risk factors for obstructive sleep apnea in children with sickle cell: a multicentric cross sectional study.Annals of hematology1 mentions
- 2022The association between obstructive sleep apnea and stroke in sickle-cell disease children.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery1 mentions
- 2022Phenotypic variation in sickle cell disease: the role of beta globin haplotype, alpha thalassemia, and fetal hemoglobin in HbSS.Expert review of hematology1 mentions
- 2022Rescue of photoreceptor with human mesenchyme stem cell and human mesenchyme stem cell expressing erythropoietin in total degeneration of retina animal model.Indian journal of ophthalmology1 mentions
- 2022Accuracy of transcranial Doppler in detecting intracranial stenosis in patients with sickle cell anemia when compared to magnetic resonance angiography.Journal of clinical ultrasound : JCU1 mentions
- 2022Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-κB pathway by leonurine attenuate iron overload-induced hepatotoxicity.Chemico-biological interactions1 mentions
- 2022Protective potential of royal jelly against hydroxyurea -induced hepatic injury in rats via antioxidant, anti-inflammatory, and anti-apoptosis properties.PloS one1 mentions
- 2022A Huge Subcapsular Splenic Cyst Like Hematoma in Sickle Cell Anemia.Cureus1 mentions
- 2022Platelet volume parameters as a tool in the evaluation of acute ischemic priapism in patients with sickle cell anemia.Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica1 mentions
- 2022Pulmonary function in children and adolescents with sickle cell disease after nonmyeloablative hematopoietic cell transplantation.Pediatric blood & cancer1 mentions
- 2022The prevalence of sickling abnormality in Oman: A review of relevant publications.Acta bio-medica : Atenei Parmensis1 mentions
- 2022Hematological and molecular analyses of the HbS allele among the Sudanese population.The Journal of international medical research1 mentions
- 2022Rheumatological picture of a patient having multifocal osteonecrosis associated with sickle cell anemia: a case study.American journal of blood research1 mentions
- 2022Cross-talk between PPARγ, NF-κB, and p38 MAPK signaling mediates the ameliorating effects of bergenin against the iron overload-induced hepatotoxicity.Chemico-biological interactions1 mentions
- 2022Prevalence of anemia in pre-school tribal children with reference to parasitic infections and nutritional impact.Journal of Taibah University Medical Sciences1 mentions
- 2022miRNA Expression Associated with HbF in Saudi Sickle Cell Anemia.Medicina (Kaunas, Lithuania)1 mentions
- 2022Deep Vein Thrombosis of the Left Lower Limb in a Sudanese Child with Sickle Cell Disease.Medicines (Basel, Switzerland)1 mentions
- 2022The Frequencies of ABO and Rh Phenotypes among Male Blood Donors in Northwestern Saudi Arabia.Clinical laboratory1 mentions
- 2022Impact of Abnormal Leukocyte Count in the Pathophysiology of Sickle Cell Anemia.Journal of blood medicine1 mentions
- 2022Skeletal and dental manifestations of Glucose-6-phosphate dehydrogenase deficiency, thalassemia, and sickle cell anemia patients in Saudi Arabia.European review for medical and pharmacological sciences1 mentions
- 2022High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia.World journal of pediatric surgery1 mentions
- 2022Deferasirox versus deferoxamine in managing iron overload in patients with Sickle Cell Anaemia: a systematic review and meta-analysis.The Journal of international medical research1 mentions
- 2022Awareness of stroke signs, symptoms, and risk factors among Jazan University students: An analytic cross-sectional study from Jazan, Saudi Arabia.Medicine1 mentions
- 2021Risk Factors and Complications Among Pediatric Patients With Sickle Cell Anemia: A Single Tertiary Center Retrospective Study.Cureus1 mentions
- 2021Sevuparin for the treatment of acute pain crisis in patients with sickle cell disease: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.The Lancet. Haematology1 mentions
- 2021Co-Inheritance of α-thalassemia gene mutation in patients with sickle cell Disease: Impact on clinical and hematological variables.Nigerian journal of clinical practice1 mentions
- 2021Commonly used agent for acute pain management of sickle cell anemia in Saudi Emergency Department: A narrative review.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2021Rare presentation of infective endocarditis due to Salmonella entrica subspecies salamae (subgroup ll) in a sickle cell anemia girl.IDCases1 mentions
- 2021Evaluation of role of HPLC (Merits & Pitfalls), in the diagnosis of various hemoglobinopathies & thalassemic syndromes.Indian journal of pathology & microbiology1 mentions
- 2021Incidence and predictors of bacterial infections in febrile children with sickle cell disease.International journal of pediatrics & adolescent medicine1 mentions
- 2021Analysis of Causes of Hospitalization Among Children with Sickle Cell Disease in a Group of Private Hospitals in Jeddah, Saudi Arabia.Journal of blood medicine1 mentions
- 2021COVID-19 in Saudi Patients With Sickle Cell Disease: A Retrospective Multi-Center Study.Cureus1 mentions
- 2021Infectious complications in adult sickle cell anemia patients undergoing hematopoietic stem cell transplantation.Bone marrow transplantation1 mentions
- 2021Testicular Volume in Children with Sickle Cell Anaemia in Uyo, a South-South Nigerian City.Journal of tropical pediatrics1 mentions
- 2021Iron Chelation Reduces DNA Damage in Sickle Cell Anemia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis1 mentions
- 2021Prevalence of Red Blood Cell Alloimmunization Among Beta-Thalassemia and Sickle Cell Anemia Patients: a Study from Saudi Arabia.Clinical laboratory1 mentions
- 2021Epidemiology of community-acquired acute kidney injury in children as seen in an emergency room of Tertiary Hospital in South-South Nigeria.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia1 mentions
- 2021Distal Renal Tubular Acidosis due to Primary Sjögren's Syndrome: Presents as Hypoakalemic Paralysis with Hypokalemia-Induced Nephrogenic Diabetes Insipidus.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia1 mentions
- 2020Multi-focal Clostridioides (Clostridium) difficile osteomyelitis in a patient with sickle cell anemia: case presentation and literature review.Diagnostic microbiology and infectious disease1 mentions
- 2020The role of hydroxyurea in decreasing the occurrence of vasso-occulusive crisis in pediatric patients with sickle cell disease at King Saud Medical City in Riyadh, Saudi Arabia.Saudi medical journal1 mentions
- 2020The Effect of Serum Ferritin Level on Gonadal, Prolactin, Thyroid Hormones, and Thyroid Stimulating Hormone in Adult Males with Sickle Cell Anemia.Journal of blood medicine1 mentions