CD4
HGNC:1678 · 59 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “Patients with EZR and ARPC1B deficiency had markedly reduced CD4+ and CD8+ T cell frequencies, whereas the BCL10-deficient patient had a near absence of NK cells, highlighting mutation-specific immune distributions.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Immunological evaluation revealed hypergammaglobulinemia, impaired T-cell proliferation, reduced CD19+ B cells, inverted CD4/CD8 ratio, and absence of CD25 expression.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “We examined how ursolic acid affects the expression of Th1 (IFN-γ, TNF-α, STAT1, STAT4, and T-bet), Th17 (IL-17, RORγt, and STAT3), and T regulatory (Treg; IL-10, TGF-β1, and Foxp3) markers in CD4+ T cells within the spleens of BTBR and C57BL/6 mice.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Splenic tissue was analyzed for oxidative stress markers, including malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD); pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and nuclear factor kappa B (NF-κB); apoptotic markers, including caspase-3 and B-cell lymphoma 2 (BCL-2); and immune-regulatory genes, including cluster of differentiation 4 and 8 (CD4 and CD8).” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “RESULTS: Four hub genes, IFNG, TNF, CD4, and CD8A, were identified as central immune regulators.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “The resultant aberrations in immunity included a selective antibody deficiency, expansion of CD8 memory and double-positive CD4+CD8+ T cells, skewed TCR repertoire, and enhanced IL-2 secretion and T-cell proliferation.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Immunological workup at 18 years of age showed CD4+ and CD8+ T-cell lymphopenia, and genetic analysis revealed a homozygous pathogenic ZAP70 splice-site mutation (c.402 + 2 T>C).” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Upregulated genes were positively associated with various immune cells, including B cells, CD8+ and CD4+ T cells, macrophages, neutrophils, and dendritic cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Cognitive and anti-inflammatory effects of Palmaria palmata in a schizophrenia mouse model: insights into CREB signaling, Iba-1 expression, and CD4+ cell modulation.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Specific genetic disorders that result in ID can also have immune system anomalies, such as changes in T (CD4+ and CD8+) cell activity.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “METHODS: This study evaluated the effect of an extensively used pyrethroid insecticide, fenpropathrin (FTN) (15 mg/kg b.wt), on the innate and humoral immune components, blood cells, splenic oxidative status, and mRNA expression of CD3, CD20, CD56, CD8, CD4, IL-6, TNF-α, and Caspase3 in a 60-day trial in rats.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “In contrast to the untreated group, animals given PZQ and/or DLE exhibited an enhanced immunological response, as indicated by increased serum IFNγ, TNFα, IL4 and IL10 levels, increased numbers of CD4 + and CD25 + cells in blood and spleen and altered expression of apoptosis-related genes (low Bax and caspase3 and high Bcl2) in the spleen.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Two cohorts of MERS-CoV survivors (31 unvaccinated, 38 COVID-19 vaccinated) were assessed for MERS-CoV IgG, memory CD4+/CD8+ T cells, and neutralizing antibodies against MERS-CoV and SARS-CoV-2 variants.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Flow cytometry was used to examinethe effects of WY14643 on the expression of IL-17A, STAT3, RORγT, IL-21, IL-21R, IL-22, and TNF-α in splenic CD4+ T cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “This study evaluated the potential efficacy of eco-friendly biofabricated zinc oxide nanoparticles (GS-ZnONP) (10 mg/kg b.wt) to reduce the impacts of long-term oral acrylamide (ALD) exposure (20 mg/kg b.wt) on the blood cells, immune components, splenic oxidative status, and expression of CD20, CD3, CD4, CD8, TNF-α, caspase-3, microRNA-181a-5p, and microRNA-125-5p in rats in a 60-day experiment.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Phenotypically, elevated cortisol level was associated with an expanded CD4 T-cell population, reduced γδ T cells percentage, decreased CD172a expression on neutrophils and monocytes, reduced CD14 and CD163 expression on monocytes, and enhanced CD45 and MHC I expression on lymphocytes.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Therefore, this study investigated the effect of DNMT inhibitor, 5-aza-2'-deoxycytidine (AZA) on DEHP-induced changes in the expression of DNMT1, global DNA methylation, and anti-/inflammatory parameters (p-STAT3, IL-17A, IL-6, iNOS, IL-10, Foxp3, Nrf2, HO-1) in the skin and the peripheral adaptive/ myeloid immune cells (CD4+ T cells/CD11b+ cells) in imiquimod (IMQ) model of psoriasiform inflammation.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Activated mice expressing a PIK3CD gain-of-function mutation (aPIK3CD) specifically within the Treg compartment exhibited weight loss and evidence for chronic inflammation, as demonstrated by increased memory/effector CD4+ and CD8+ T cells with enhanced IFN-γ secretion, spontaneous germinal center responses, and production of broad-spectrum autoantibodies.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Furthermore, correlational analyses revealed the positive and negative correlations among the expression of the real hub genes and various ancillary data, including tumor purity, promoter methylation status, overall survival (OS), genetic alterations, infiltration of CD8+ T and CD4+ immune cells, and a few more, across TNBC samples.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “This study aims to determine whether HVEM is an immune checkpoint target with inhibitory effects on anti-tumor CD4+ T cell responses in vitro and whether HVEM gene expression is dysregulated in patients with acute lymphocytic leukemia (ALL).” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Immune cell infiltration analysis demonstrated robust positive correlations between DSCC1 expression and CD8+ T cells, CD4+ T cells, and B cells, influencing the tumor microenvironment.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Analysis of immune cell infiltration revealed a positive correlation between HS6ST2 expression and the infiltration of CD8+ T and CD4+ T cells in CESC, KICH, LUAD, and STAD, highlighting its involvement in the tumor immunology processes.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Correlation analysis revealed positive associations between CDCA8 expression and infiltrating immune cells, particularly CD8+ and CD4+ T cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “TAOK3 expression is positively correlated with immune infiltrates, which include activated CD4 T cells, CD8 T cells, and type 2T helper cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Immunophenotyping demonstrated a predominance of CD3+ T cells with a 1:1 CD4/CD8 ratio and reduced CD7 expression.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “It has been demonstrated that several genetic and epigenetic factors control autoimmune encephalomyelitis (EAE), a murine model of MS, through CD4+ T-cell population quantity.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Aged mice expressing a PIK3CD gain-of-function mutation (aPIK3CD) specifically within the Treg compartment exhibited weight loss and evidence for chronic inflammation as demonstrated by increased memory/effector CD4+ and CD8+ T cells with enhanced IFN-γ secretion, spontaneous germinal center responses and production of broad-spectrum autoantibodies.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Piezo1 is a mechanosensitive cation channel with high expression on both CD4+ and CD8+ T cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Further analyses demonstrated positive correlations between MCM10 expression and immune cell infiltration, particularly CD8+ T cells and CD4+ T cells, offering insights into the gene's influence on the tumor immune microenvironment.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Immune infiltration analysis showed significant associations between SLC31A1 expression and the presence of CD8+ T cells, CD4+ T cells, and macrophages in the tumor microenvironment.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “GPC3 expression was also found to correlate significantly with infiltration of B cells, CD8+, CD4+, macrophages, neutrophils, and dendritic cells in LUAD.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “In addition, hub genes were involved in the "Fc epsilon RI signaling pathway, asthma, natural cell killer mediated cytotoxicity, T cell receptor signaling pathway, primary immunodeficiency, Fc gamma R-mediated phagocytosis, malaria, leukocyte transendothelial migration, and legionellosis" pathways and associated with the infiltration level of CD8+ T, CD4+ T, and macrophage cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Further correlational analyses showed diverse associations among real hub genes' expression and other important parameters, including promoter methylation status, genetic alteration, overall survival (OS), relapse-free survival (RFS), tumor purity, CD8+ T, CD4+ T immune cell infiltration, and different mutant genes across BRIC samples.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “The highest level of mutation occurred in naïve CD4+ T cells (median, 51.2%; range, 3.8%-93.5%).” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “In addition, patients with T2DM showed lower percentage of total T-lymphocytes (CD3+) and CD4 T-cells, but higher CD8 T-cell expression.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Immune cell restriction findings show that above three genes are highly expressed by T-follicular helper CD4+ T cells, naïve B cells, and monocytes, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “The patient had a low CD4 count at presentation, however, he was HIV negative at the time of diagnosis; also Human herpesvirus-8 was negative on immunohistochemical stain, but Epstein-Barr virus showed expression in scattered cells through the utilization of EBV-EBER.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “We characterised time-series of primary human naïve CD4+ T cells during early T helper type 1 differentiation with RNA-sequencing and mass-spectrometry proteomics.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “This study investigated effect of DEHP exposure during juvenile period on DNA methylation (global DNA methylation/DNMT1 expression) and inflammation (IL-17A, IL-6, MCP-1, TNF-α) in CD4 + T cells/CD11c + DCs and cortex, and autism-like symptoms (three-chambered sociability test, self-grooming and marble burying test) in asocial BTBR and social C57 mice at adulthood.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “AIM: The purpose of this study was to assess the expression of CD204+ M2-polarized TAMs in glioblastomas and their relationship with CD4+TILs, Iba+microglia, and IDH1 mutation.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “We define credible sets of T1D-associated variants and show that they are enriched in immune-cell accessible chromatin, particularly CD4+ effector T cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Material & methods: We generated paired assay for transposase-accessible chromatin sequencing and RNA-sequencing profiles from sorted blood immune CD4+ and CD8+ T cells, CD14+ monocytes and CD19+ B cells from healthy controls (HCs) and MS patients.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “CARMIL2 protein expression was significantly reduced in CD4+ T cells and CD8+ T cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Association of IL-10 Gene Polymorphism With IL-10 Secretion by CD4 and T Regulatory Cells in Human Leprosy.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Further, sulforaphane-treated BTBR mice had reduced Th17 immune responses (STAT3, RORC, IL-17 A and IL-23R expression in CD4 + T cells), oxidative stress parameters in neutrophils/cerebellum (NFkB, iNOS, and lipid peroxides).” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “We examined IL-16 expression in CD4+, CD8+, CD14+, CCR3+, and CXCR7+ cells in typically developing (TD) controls and children with ASD using flow cytometry in peripheral blood mononuclear cells (PBMCs).” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “The study aimed to assess the tangled relation between various CD25 subsets (positive, negative and high) of CD4+ FoxP3+ T cells and H. pylori including its virulence genes (CagA and VacA).” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Upregulation of peripheral CXC and CC chemokine receptor expression on CD4+ T cells is associated with immune dysregulation in children with autism.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “The expression of PD-1 as well as co-expression of negative immune checkpoints TIM-3 and LAG-3 on PD-1 positive cells were increased on both CD4 as well as CD8 T cells upon interaction with and priming by NK-DC cross talk cultures exposed to C-HIV.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells from a BTBR T+ Itpr3tf/J mouse model of autism.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “We previously revealed that Tregs rapidly suppress T cell receptor (TCR)-induced calcium store depletion in conventional CD4+CD25- T cells (Tcons) independently of IP3 levels, consequently inhibiting NFAT signaling and effector cytokine expression.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Further, we examined the effects of A2ARs on the expression of the cytokines interleukin 2 (IL-2), IL-6, IL-9, interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and transforming growth factor β (TGF-β) in the spleen and in splenic CD4+ T cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “In this study, we investigated the potential effects of the A2A adenosine receptor (A2AR) antagonist SCH 5826 (SCH) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A+, RORγt+, Foxp3+, and IL-10+ in CD4+ T spleen cells in BTBR and C57BL/6 (B6) mice.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “In our study, cells from children with AU had increased IL-21 and IL-22 and decreased CTLA-4 expression on CD4+ T cells as compared with cells from the TD control.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated that they profoundly affect the magnitude of polyclonal T cell response, particularly CD4(+) T cells and expression of CD45RA and CD45RO, and cytokine secretion in vitro in SLE patient PBMCs.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Replication using whole-blood DNA from 2377 White adults in the Framingham Heart Study and CD4+ T cell DNA from 991 Whites in the Genetics of Lipid Lowering Drugs and Diet Network Study was followed by testing using adipose tissue DNA from 648 women in the Multiple Tissue Human Expression Resource cohort.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “Adenoviral vectors secreting NP-CD40L fusion protein (denoted as rAd-SNP40L) afforded full protection of immunocompetent and immunocompromised mice (CD40L(-/-) and CD4(-/-)) against lethal influenza infection.” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “We investigated the expression of T-cell markers (CD3, CD4, and CD8), B cells (CD19), and natural killer cells (CD16 and CD56).” | 0.98 | hgnc_dict_v1 |
| gene | CD4 | “His peripheral blood lymphocytes were found to contain predominant CD4+ CD45R+ T cells with a clear deficiency of CD4+ CDw29+ as well as CD8+ T cells.” | 0.98 | hgnc_dict_v1 |