thyroid cancer
SaudiVarKB evidence summary derived from retained literature mentions.
187Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| BRAF | HGNC:1097 | 51 | 51 |
| TERT | HGNC:11730 | 25 | 25 |
| RET | HGNC:9967 | 14 | 14 |
| NRAS | HGNC:7989 | 11 | 11 |
| KRAS | HGNC:6407 | 9 | 9 |
| HRAS | HGNC:5173 | 9 | 9 |
| PIK3CA | HGNC:8975 | 8 | 8 |
| PTEN | HGNC:9588 | 7 | 7 |
| EIF1AX | HGNC:3250 | 6 | 6 |
| TP53 | HGNC:11998 | 5 | 5 |
| BRCA2 | HGNC:1101 | 4 | 4 |
| TG | HGNC:11764 | 3 | 3 |
| CTNNB1 | HGNC:2514 | 3 | 3 |
| XIAP | HGNC:592 | 3 | 3 |
| NF1 | HGNC:7765 | 2 | 2 |
| ATM | HGNC:795 | 2 | 2 |
| MMP9 | HGNC:7176 | 2 | 2 |
| POLE | HGNC:9177 | 2 | 2 |
| CYP24A1 | HGNC:2602 | 2 | 2 |
| CHEK2 | HGNC:16627 | 2 | 2 |
| IDH1 | HGNC:5382 | 2 | 2 |
| IDH2 | HGNC:5383 | 2 | 2 |
| GAS8-AS1 | HGNC:1197 | 2 | 2 |
| POLD1 | HGNC:9175 | 2 | 2 |
| PPM1D | HGNC:9277 | 2 | 2 |
| SIRT1 | HGNC:14929 | 1 | 1 |
| TNF | HGNC:11892 | 1 | 1 |
| COL8A2 | HGNC:2216 | 1 | 1 |
| CD34 | HGNC:1662 | 1 | 1 |
| NAT2 | HGNC:7646 | 1 | 1 |
| DNMT3A | HGNC:2978 | 1 | 1 |
| STAT3 | HGNC:11364 | 1 | 1 |
| STAT1 | HGNC:11362 | 1 | 1 |
| MTHFR | HGNC:7436 | 1 | 1 |
| SPTA1 | HGNC:11272 | 1 | 1 |
| IL2RG | HGNC:6010 | 1 | 1 |
| IL10 | HGNC:5962 | 1 | 1 |
| GNAS | HGNC:4392 | 1 | 1 |
| MAP2K1 | HGNC:6840 | 1 | 1 |
| BRCA1 | HGNC:1100 | 1 | 1 |
| AKT1 | HGNC:391 | 1 | 1 |
| CA2 | HGNC:1373 | 1 | 1 |
| ATG5 | HGNC:589 | 1 | 1 |
| MSH6 | HGNC:7329 | 1 | 1 |
| RAD51 | HGNC:9817 | 1 | 1 |
| DICER1 | HGNC:17098 | 1 | 1 |
| CGA | HGNC:1885 | 1 | 1 |
| STK11 | HGNC:11389 | 1 | 1 |
| MMP8 | HGNC:7175 | 1 | 1 |
| HLA-C | HGNC:4933 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| V600E | V600E | 18 | 18 |
| C228T | C228T | 4 | 4 |
| V600E | V600E | 3 | 3 |
| V600E | V600E | 2 | 2 |
| K601E | K601E | 2 | 2 |
| C250T | C250T | 2 | 2 |
| C250T | C250T | 2 | 2 |
| c.1901G>C | c.1901G>C | 1 | 1 |
| p.Cys634Ser | p.Cys634Ser | 1 | 1 |
| c.760C>T | c.760C>T | 1 | 1 |
| p.Q254* | p.Q254* | 1 | 1 |
| p.V804M | p.V804M | 1 | 1 |
| c.3132T>G | c.3132T>G | 1 | 1 |
| p.R2223H | p.R2223H | 1 | 1 |
| c.6725G>A | c.6725G>A | 1 | 1 |
| c.6396C>T | c.6396C>T | 1 | 1 |
| p.S2113L | p.S2113L | 1 | 1 |
| c.2200T>G | c.2200T>G | 1 | 1 |
| c.3082A>G | c.3082A>G | 1 | 1 |
| R721G | R721G | 1 | 1 |
| A756D | A756D | 1 | 1 |
| Y791C | Y791C | 1 | 1 |
| E734K | E734K | 1 | 1 |
| E805K | E805K | 1 | 1 |
| F893L | F893L | 1 | 1 |
| R897Q | R897Q | 1 | 1 |
| R897G | R897G | 1 | 1 |
| R912Q | R912Q | 1 | 1 |
| R912G | R912G | 1 | 1 |
| M918T | M918T | 1 | 1 |
| p.Met918Thr | p.Met918Thr | 1 | 1 |
| p.Arg897Gln | p.Arg897Gln | 1 | 1 |
| G13R | G13R | 1 | 1 |
| p.R304Q | p.R304Q | 1 | 1 |
| p.R175H | p.R175H | 1 | 1 |
| c.22G>A | c.22G>A | 1 | 1 |
| c.617A>C | c.617A>C | 1 | 1 |
| c.824C>T | c.824C>T | 1 | 1 |
| c.162_163insGAG | c.162_163insGAG | 1 | 1 |
| c.1126C>G | c.1126C>G | 1 | 1 |
| c.769G>T | c.769G>T | 1 | 1 |
| c.76A>G | c.76A>G | 1 | 1 |
| c.1323_1325del | c.1323_1325del | 1 | 1 |
| c.347C>T | c.347C>T | 1 | 1 |
| c.1799T>A | c.1799T>A | 1 | 1 |
| G12D | G12D | 1 | 1 |
| rs113488022 | rs113488022 | 1 | 1 |
| rs77709286 | rs77709286 | 1 | 1 |
| n.714T>C | n.714T>C | 1 | 1 |
| rs55742939 | rs55742939 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Circulating microRNA electrochemical assays in thyroid cancer.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Synchronous Presence of Papillary, Medullary, and Anaplastic Thyroid Tumors in a Single Patient: A Rare Case Report.The American journal of case reports1 mentions
- 2026Papillary Thyroid Carcinoma in Patients with Carotid Body Tumors: Prevalence and Management in a Retrospective Surgical Series from Two Tertiary Centers.Journal of clinical medicine1 mentions
- 2026Radioactive iodine effects on ovarian reserve: a systematic review and metaanalysis.Frontiers in endocrinology1 mentions
- 2026STK11 and DNA Repair Gene Mutations Define Hereditary Subset of Middle Eastern Papillary Thyroid Cancer.International journal of molecular sciences1 mentions
- 2026Recurrent primary hyperparathyroidism with ipsilateral multifocal papillary thyroid carcinoma of classical, warthin-like, and follicular variants harboring distinct BRAF and NRAS mutations: a rare case report.World journal of surgical oncology1 mentions
- 2026Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements.Redox biology1 mentions
- 2026Positron emission tomography tracers in medullary thyroid carcinoma: Current evidence and emerging targets.World journal of radiology1 mentions
- 2026Ethnic Background as a Determinant of Thyroid Cancer Risk: A Decade-Long National Cohort Study Reveals Divergent Epidemics in Saudi Arabia.Saudi medical journal1 mentions
- 2026LncRNA GAS8-AS1 is downregulated, correlates with early-stage disease and lymph node metastasis, and its knockdown promotes proliferation, migration, and invasion in differentiated thyroid cancer.Frontiers in endocrinology1 mentions
- 2026Modeling the Effects of Single Nucleotide Polymorphisms (SNPs) on the Structure and Function of the Human RET Gene: An In Silico Study.Human mutation1 mentions
- 2025The Prognostic Impact of Tumor Size and BRAF Mutational Status in Middle Eastern Differentiated Thyroid Cancer.The Journal of clinical endocrinology and metabolism1 mentions
- 2025Prognostic Indicators and Comparative Treatment Outcomes in High-Risk Thyroid Cancer with Laryngotracheal Invasion.Endocrinology and metabolism (Seoul, Korea)1 mentions
- 2025Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis.Frontiers in endocrinology1 mentions
- 2025Characteristics and Prognostic Markers of Aggressive Subtypes of Thyroid Cancer: A Retrospective Study.Cancer reports (Hoboken, N.J.)1 mentions
- 2025Deciphering the role of Hashimoto's Thyroiditis-related key genes in thyroid cancer via detailed in silico analysis followed by the experimental validation.Hereditas1 mentions
- 2025Identification of novel prognostic biomarkers for thyroid cancer by integrated transcriptome analysis of metastasis-associated genes.Frontiers in oncology1 mentions
- 2025What Is a Significant Nuclear Groove in Thyroid Fine Needle Aspiration Cytology?Diagnostic cytopathology1 mentions
- 2025Synchronous presentation of Hodgkin lymphoma and papillary thyroid carcinoma in a young patient: a case review.Journal of surgical case reports1 mentions
- 2025Exploring the Public Awareness of Thyroid Cancer in Northern Saudi Arabia: A Preliminary Stage for Health Promotion.Healthcare (Basel, Switzerland)1 mentions
- 2025Role of TERT gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review).Molecular and clinical oncology1 mentions
- 2025Tall Cell Variant Histology Predicts Poorer Disease-Free Survival in Papillary Thyroid Carcinoma: A Propensity-Matched Cohort Study.World journal of surgery1 mentions
- 2025Warthin-like variant of papillary thyroid carcinoma: a rare case report.Journal of surgical case reports1 mentions
- 2025Re: Tall Cell Variant Histology Predicts Poorer Disease-Free Survival in Papillary Thyroid Carcinoma: A Propensity Matched Cohort Study.World journal of surgery1 mentions
- 2025Olive Oil Polyphenols: A Promising Approach for Cancer Prevention and Therapy.Food science & nutrition1 mentions
- 2025From Inconclusive Fine Needle Aspiration to Double Malignancies: A Case Report of Primary Thyroid Lymphoma With Concurrent Papillary Thyroid Carcinoma in a Sickle Cell Disease Patient in Saudi Arabia.Cureus1 mentions
- 2025Genetic alterations in papillary thyroid cancer: clinicopathological correlations and diagnostic implications.Folia histochemica et cytobiologica1 mentions
- 2025Optimizing high dimensional data classification with a hybrid AI driven feature selection framework and machine learning schema.Scientific reports1 mentions
- 2025Germline Telomere-Regulating Gene Variants Are Not Associated with Thyroid Cancer in a Saudi Arabian Population.Thyroid : official journal of the American Thyroid Association1 mentions
- 2025Associations between cadmium and lead exposure and thyroid disorders: A systematic review and meta-analysis.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)1 mentions
- 2025Prognostic factors for survival and recurrence in papillary thyroid carcinoma: a retrospective study.Gland surgery1 mentions
- 2025Advances in genetic and molecular insights into thyroid disorders: Implications for diagnosis, prognosis, and personalized treatment.Saudi medical journal1 mentions
- 2025Circulating MiRNAs in thyroid cancer: prognostic promise of miR-155 and limitations of miR-429.Molecular biology reports1 mentions
- 2025No prognostic or molecular disparity between synchronous and metachronous metastases in differentiated thyroid cancer: insight from middle eastern cohort.International journal of surgery (London, England)1 mentions
- 2025Familial Risk Factors in Thyroid Cancer Across Generations and Geographics: A Systematic Review and Meta-Analysis.Current oncology (Toronto, Ont.)1 mentions
- 2025Papillary thyroid carcinoma and primary aldosteronism: A new syndrome or a mere association?World journal of clinical cases1 mentions
- 2025De novo mutation of the RET proto-oncogene revealing multiple endocrine neoplasia type 2A: a sporadic case from Western Algeria.The Gulf journal of oncology1 mentions
- 2024PLK1 and FoxM1 expressions positively correlate in papillary thyroid carcinoma and their combined inhibition results in synergistic anti-tumor effects.Molecular oncology1 mentions
- 2024LncRNA GAS8-AS1 dinucleotide genetic variantn.713A>G, n.714T>C is associated with early-stage disease, lymph node, and distant metastasis in differentiated thyroid cancer.Endocrine1 mentions
- 2024BRAF and RET polymorphism association with thyroid cancer risk, a preliminary study from Khyber Pakhtunkhwa population.Molecular biology reports1 mentions
- 2024Histone H3 trimethylation on lysine 27 immunostaining pattern in DICER1-associated tumors.Translational pediatrics1 mentions
- 2024Radioactive iodine refractoriness in Middle Eastern differentiated thyroid cancer: clinical outcome and risk factor analysis.Frontiers in endocrinology1 mentions
- 2024Thyroid cancer trends in China and its comparative analysis with G20 countries: Projections for 2020-2040.Journal of global health1 mentions
- 2024Diagnostic utility of anti-thyroid peroxidase immunohistochemistry in the identification of papillary thyroid carcinoma.Annals of diagnostic pathology1 mentions
- 2024Pediatric thyroid cancer in Saudi Arabia: a literature review of current trends in management and outcomes.Gland surgery1 mentions
- 2024Referred otalgia in patients with thyroid cancer: Case series from Saudi Arabia.International journal of surgery case reports1 mentions
- 2024DEL-Thyroid: deep ensemble learning framework for detection of thyroid cancer progression through genomic mutation.BMC medical informatics and decision making1 mentions
- 2024Cheminformatics-based identification of phosphorylated RET tyrosine kinase inhibitors for human cancer.Frontiers in chemistry1 mentions
- 2024Association of the Genetic Diversity of Killer Cell Immunoglobulin-like Receptor Genes and HLA-C Ligand in Saudi Women With Thyroid Cancer.Cancer control : journal of the Moffitt Cancer Center1 mentions
- 2024Clinical and Histopathological Features of Thyroid Cancer with TERT Promoter Molecular Alterations in Isolation Versus with Concurrent Molecular Alterations: A Multicenter Retrospective Study.Cancers1 mentions
- 2024The role of genetic and epigenetic modifications as potential biomarkers in the diagnosis and prognosis of thyroid cancer.Frontiers in oncology1 mentions
- 2024A novel role for nonactin: interfering with G-quadruplex in RET-driven medullary thyroid cancer.BMC cancer1 mentions
- 2024Molecular Mutations and Clinical Behavior in Bethesda III and IV Thyroid Nodules: A Comparative Study.Cancers1 mentions
- 2024Clinicopathological Characteristics of Thyroid Cancer: A 10-Year Experience at a Tertiary Care Center in Saudi Arabia.Cureus1 mentions
- 2023Risk of Adverse Cardiovascular Outcomes in Differentiated Thyroid Cancer Survivors: A Systematic Review and Meta-Analysis.Thyroid : official journal of the American Thyroid Association1 mentions
- 2023Identification of potential inhibitor targeting KRAS mutation in Papillary Thyroid Carcinoma through molecular docking and dynamic simulation analysis.Computers in biology and medicine1 mentions
- 2023Effect of Having Concurrent Mutations on the Degree of Aggressiveness in Patients with Thyroid Cancer Positive for TERT Promoter Mutations.Cancers1 mentions
- 2023Overexpression of the pro-protein convertase furin predicts prognosis and promotes papillary thyroid carcinoma progression and metastasis through RAF/MEK signaling.Molecular oncology1 mentions
- 2023Molecular Genetics of Diffuse Sclerosing Papillary Thyroid Cancer.The Journal of clinical endocrinology and metabolism1 mentions
- 2023Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes.Cancers1 mentions
- 2023Vandetanib.Profiles of drug substances, excipients, and related methodology1 mentions
- 2023Food Toxicity of Mycotoxin Citrinin and Molecular Mechanisms of Its Potential Toxicity Effects through the Implicated Targets Predicted by Computer-Aided Multidimensional Data Analysis.Life (Basel, Switzerland)1 mentions
- 2023Thyroid Cancer, Neuroendocrine Tumor, Adrenal Adenoma, and Other Tumors in a Patient With a Germline PMS1 Mutation.Journal of the Endocrine Society1 mentions
- 2023Clinical use of Molecular Data in Thyroid Nodules and Cancer.The Journal of clinical endocrinology and metabolism1 mentions
- 2023In silico Screening and Validation of Achyranthes aspera as a Potential Inhibitor of BRAF and NRAS in Controlling Thyroid Cancer.Anti-cancer agents in medicinal chemistry1 mentions
- 2023β-catenin attenuation leads to up-regulation of activating NKG2D ligands and tumor regression in BrafV600E-driven thyroid cancer cells.Frontiers in immunology1 mentions
- 2023Osseous Metastases in Thyroid Cancer: Unveiling Risk Factors, Disease Outcomes, and Treatment Impact.Cancers1 mentions
- 2023Challenges and Opportunities in the Crusade of BRAF Inhibitors: From 2002 to 2022.ACS omega1 mentions
- 2023Whole Exome-Wide Association Identifies Rare Variants in GALNT9 Associated with Middle Eastern Papillary Thyroid Carcinoma Risk.Cancers1 mentions
- 2023How do BRAFV600E and TERT promoter mutations interact with the ATA and TNM staging systems in thyroid cancer?Frontiers in endocrinology1 mentions
- 2023Loss of CDH16 expression is a strong independent predictor for lymph node metastasis in Middle Eastern papillary thyroid cancer.Scientific reports1 mentions
- 2023Matrix Metalloproteinase 9/microRNA-145 Ratio: Bridging Genomic and Immunological Variabilities in Thyroid Cancer.Biomedicines1 mentions
- 2023Anaplastic thyroid cancer: Pathogenesis, prognostic factors and genetic landscape (Review).Molecular and clinical oncology1 mentions
- 2023Impact of iodine supplementation and mtDNA mutations on papillary thyroid cancer in saudi women following a vegetarian diet.Cellular and molecular biology (Noisy-le-Grand, France)1 mentions
- 2023Metastatic papillary thyroid carcinoma in pleural effusion: a case report and review of the literature.Journal of medical case reports1 mentions
- 2023The Impact of BRAF V600E Mutation Allele Frequency on the Histopathological Characteristics of Thyroid Cancer.Cancers1 mentions
- 2022Controversy on the management of patients carrying RET p.V804M mutation.Endocrine1 mentions
- 2022Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models.Scientific reports1 mentions
- 2022Identification of DPP4/CTNNB1/MET as a Theranostic Signature of Thyroid Cancer and Evaluation of the Therapeutic Potential of Sitagliptin.Biology1 mentions
- 2022GLUT1 and ASCT2 Protein Expression in Papillary Thyroid Carcinoma Patients and Relation to Hepatitis C Virus: A Propensity-Score Matched Analysis.International journal of general medicine1 mentions
- 2022APOBEC SBS13 Mutational Signature-A Novel Predictor of Radioactive Iodine Refractory Papillary Thyroid Carcinoma.Cancers1 mentions
- 2022Male Sex Is an Independent Predictor of Recurrence-Free Survival in Middle Eastern Papillary Thyroid Carcinoma.Frontiers in endocrinology1 mentions
- 2022TERT Promoter Mutations Are an Independent Predictor of Distant Metastasis in Middle Eastern Papillary Thyroid Microcarcinoma.Frontiers in endocrinology1 mentions
- 2022Analysis of anti-apoptotic PVT1 oncogene and apoptosis-related proteins (p53, Bcl2, PD-1, and PD-L1) expression in thyroid carcinoma.Journal of clinical laboratory analysis1 mentions
- 2022Risk Factors for TERT Promoter Mutations with Papillary Thyroid Carcinoma Patients: A Meta-Analysis and Systematic Review.Computational and mathematical methods in medicine1 mentions
- 2022Papillary Thyroid Cancer and a TERT Promotor Mutation-positive Paraganglioma in a Patient With a Germline SDHB Mutation.Journal of the Endocrine Society1 mentions
- 2022Fumarate Hydratase is a Novel Gene for Familial Non-Medullary Thyroid Cancer.The Journal of clinical endocrinology and metabolism1 mentions
- 2022Large-scale transcriptomic analysis of coding and non-coding pathological biomarkers, associated with the tumor immune microenvironment of thyroid cancer and potential target therapy exploration.Frontiers in cell and developmental biology1 mentions
- 2022Molecular Testing for Thyroid Nodules: The Experience at McGill University Teaching Hospitals in Canada.Cancers1 mentions
- 2022Radicular variant of dens in dente (RDinD) in a patient undergoing radioisotope therapy.Journal of Taibah University Medical Sciences1 mentions
- 2022High COX-2 immunostaining in papillary thyroid carcinoma is associated with adverse survival outcomes.Annals of Saudi medicine1 mentions
- 2022TSH-β gene polymorphism in Saudi patients with thyroid cancer: A case-control study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2022Molecular Landscape of Pediatric Thyroid Cancer: A Review.Diagnostics (Basel, Switzerland)1 mentions
- 2022X-linked inhibitor of apoptosis protein (XIAP) predicts disease-free survival in BRAFV600E mutant papillary thyroid carcinoma in middle eastern patients.Frontiers in endocrinology1 mentions
- 2021VE1 immunohistochemistry is an adjunct tool for detection of BRAFV600E mutation: Validation in thyroid cancer patients.Journal of clinical laboratory analysis1 mentions
- 2021Single nucleotide polymorphisms in matrix metalloproteinase 2 (MMP2) enhance BRAFV600E mutation-mediated oncogenicity and invasiveness of papillary thyroid cancer cells.Endocrine-related cancer1 mentions
- 2021Lenvatinib-induced multiorgan adverse events in Hurthle cell thyroid cancer: A case report.World journal of clinical oncology1 mentions
- 2021Recurrent Somatic MAP2K1 Mutations in Papillary Thyroid Cancer and Colorectal Cancer.Frontiers in oncology1 mentions
- 2021Selective Antitumor Activity of Datelliptium toward Medullary Thyroid Carcinoma by Downregulating RET Transcriptional Activity.Cancers1 mentions
- 2021β-Catenin Attenuation Inhibits Tumor Growth and Promotes Differentiation in a BRAFV600E-Driven Thyroid Cancer Animal Model.Molecular cancer therapeutics1 mentions