CYP2D6
HGNC:2625 · 33 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP2D6 | “With respect to literature, the polymorphisms in the key metabolic enzymes CYP2D6, UGT2B7, and COMT, as well as variations in the OPRM1, are important modifiers of the pharmacokinetics and pharmacodynamics of opioids.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “For metabolism, most drugs rely on CYP3A-mediated metabolism, primarily through CYP3A4, CYP2D6, and CYP2C8.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Pharmacogenomic factors, especially CYP2D6 and CYP1A2 polymorphisms, significantly influence duloxetine metabolism and therapeutic response.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “We evaluated CYP2D6/CYP2C19 and three drug classes (opioids, selective serotonin reuptake inhibitors [SSRIs], proton pump inhibitors [PPIs]).” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “This review examines current evidence on how selected herbal extracts influence key enzymes such as cytochrome P450 family 3 subfamily A member 4 (CYP3A4), cytochrome P450 family 2 subfamily D member 6 (CYP2D6), cytochrome P450 family 2 subfamily C member 9 (CYP2C9), and UDP-glucuronosyltransferases (UGTs), and highlights the implications for drug safety and efficacy.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “AIM: To investigate the impact of tamoxifen dose, CYP2D6 inhibitors, CYP2D6*4 genotype, and non-genetic parameters on the outcomes of tamoxifen treated female breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “The Axiom PharmacoFocus Array technique was employed to generate accurate star allele-predicted phenotypes of 3 PK genes (CYP3A4, CYP3A5, and CYP2D6).” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “DNA was isolated from Ph-ve CML patients and a control group for PCR-RFLP analysis of SNPs CYP1A1*2C and CYP2D6*4.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Key genetic markers, such as the APOE ε4 allele in AD and the CYP2D6 polymorphisms in PD, are highlighted for their roles in modulating drug efficacy.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Notably, 6 CYP2D6 variants exhibited strong linkage disequilibrium; however, they significantly influenced only the metabolic ratio and had no considerable effects on the individual estimates of RIS, 9-OH-RIS, or the total active moiety.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “The Frequency of CYP2D6 and CYP3A4/5 Genotypes and The Impact of Their Allele Translation and Phenoconversion-Predicted Enzyme Activity on Risperidone Pharmacokinetics in Saudi Children with Autism.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Those samples of 1-hexadecanol were found to be 1-hexadecanol (BBB 0.783), GI High, Pgp Substrate Yes, CYP2C19 Inhibitor Yes, CYP2D6 Yes, and HI -89.803.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “We assessed the performance of seven sequence-based (SIFT, PolyPhen2, mutation accessor, FATHMM, PhD-SNP, MutPred2, and SNPs & Go) and five structure-based (mCSM, SDM, DDGun, CupSat, and MAESTROweb) tools in predicting the impact of 118 nsSNPs in the CYP2C19, CYP2C9, CYP2B6, CYP2D6, and DPYD genes with known function (24 normal, one increased, 42 decreased, and 51 no-function).” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “In in silico ADME prediction, ALC was shown to have poor water solubility and high gastrointestinal absorption along with inhibition of some cytochrome P450s (CYP2C19 and CYP2C9) without inhibition of others (CYP1A2, CYP3A4, and CYP2D6) and P-glycoprotein substrate.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Profiling of pharmacogenomic variants in CYP2D6 and DPYD in indigenous Arab breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Corrigendum to "Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6) are associated with long term tramadol treatment-induced oxidative damage and hepatotoxicity" [Toxicology and Applied Pharmacology 346 (2018) 37-44].” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “CYP2D6 genetic polymorphisms in Saudi systemic lupus erythematosus patients: A cross-sectional study.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “The cytochrome P450 genes (CYP2C9, CYP2C19, and CYP2D6) were estimated to impact responses of 54.3% (n = 1,156,113) of the used drugs (27.2% are possibly affected by CYP2C9, 12.8% by CYP2C19, and 14.3% by CYP2D6).” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Literature mining based variant analysis highlighted the importance of rs1800716 variant, located on the CYP2D6 gene, involved in a range of important functions, such as RNA spicing, drug interaction, death, and urotoxicity.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “We hypothesized that a potential confounding variable for not finding differences in Length of Stay and Re-admission rate in a major depression clinical trial is the equivalence between treatment protocols in the standard treatment (S) and CYP2D6 genotype (G) treatment groups.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “The impact of CYP2D6*41 on CYP2D6 enzyme activity using phenotyping methods in urine, plasma, and saliva.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Frequencies of CYP2D6 genetic polymorphisms in Arab populations.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “We identify eight novel associations after Bonferroni correction, three of which are replicated or validated in the UK Biobank or have other supporting results: The C-allele at rs4918758 in CYP2C9 was associated with a 25% (15-44%) lower odds of dose reduction of quinine, P = 1.6 × 10-5 ; the A-allele at rs9895420 in ABCC3 was associated with a 46% (24-62%) reduction in odds of dose reduction with doxazosin, P = 1.2 × 10-4 , and altered blood pressure response in the UK Biobank; the CYP2D6*2 variant was associated with a 30% (18-40%) reduction in odds of stopping ramipril treatment, P = 1.01 × 10-5 , with similar results seen for enalapril and lisinopril and with other CYP2D6 variants.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Missense variants were filtered as potential nonsynonymous single nucleotide polymorphisms among the available data for the target genes (REN, CYP2D6, CYP3A4).” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Among DMEs, deleterious mutation in dihydropyrimidine dehydrogenase (DPYD; rs67376798), solute carrier organic anion transporter family member 1B1 (SLCO1B1*5), and cytochrome P450 2D6 (CYP2D6*10) associated with metabolism of anticancer drugs was detected to be in high frequency of 26%, 21% and 25% respectively.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “We aimed to summarize and investigate the current evidence regarding the frequency of CYP2D6, CYP2C9, CYP2C19, and MDR1 in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “CYP1A1 and CYP2D6 Polymorphisms and Susceptibility to Chronic Myelocytic Leukaemia.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “This study aimed at investigating the association of CYP2D6*2A (rs1080985) and CYP2D6*10 (rs1065852) single-nucleotide polymorphism (SNP) with Bisoprolol response in cardiac patients attending King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Full-gene haplotypes refine CYP2D6 metabolizer phenotype inferences.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “In this review, we discuss some of the most clinically important CYPs isoforms (CYP2D6, CYP2A6, CYP2C19, CYP2C9, CYP1B1 and CYP1A2) with respect to gene polymorphisms and drug metabolism.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “The pharmacogene, CYP2D6, is commonly used to infer metabolizer phenotype of many marketed drugs and endogenous toxins in ante- and post-mortem patients but only represents the efficiency of phase 1 metabolism.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2D6 | “Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians.” | 0.98 | hgnc_dict_v1 |