multiple sclerosis
SaudiVarKB evidence summary derived from retained literature mentions.
195Phenotype mentions
100Publications
50Associated gene records
37Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| HLA-DRB1 | HGNC:4948 | 5 | 5 |
| MBP | HGNC:6925 | 4 | 4 |
| CD4 | HGNC:1678 | 3 | 3 |
| BDNF | HGNC:1033 | 3 | 3 |
| IRF4 | HGNC:6119 | 2 | 2 |
| MT-ND4 | HGNC:7459 | 2 | 2 |
| CD19 | HGNC:1633 | 2 | 2 |
| CD14 | HGNC:1628 | 2 | 2 |
| PARP1 | HGNC:270 | 1 | 1 |
| TNF | HGNC:11892 | 1 | 1 |
| STAT6 | HGNC:11368 | 1 | 1 |
| SOD1 | HGNC:11179 | 1 | 1 |
| IL2RA | HGNC:6008 | 1 | 1 |
| AQP4 | HGNC:637 | 1 | 1 |
| LIPA | HGNC:6617 | 1 | 1 |
| STAT4 | HGNC:11365 | 1 | 1 |
| IL10 | HGNC:5962 | 1 | 1 |
| CDC42 | HGNC:1736 | 1 | 1 |
| LRRK2 | HGNC:18618 | 1 | 1 |
| PINK1 | HGNC:14581 | 1 | 1 |
| MECP2 | HGNC:6990 | 1 | 1 |
| CNP | HGNC:2158 | 1 | 1 |
| SYNE1 | HGNC:17089 | 1 | 1 |
| AKT1 | HGNC:391 | 1 | 1 |
| MALAT1 | HGNC:29665 | 1 | 1 |
| PTPN22 | HGNC:9652 | 1 | 1 |
| VDR | HGNC:12679 | 1 | 1 |
| SOX5 | HGNC:11201 | 1 | 1 |
| CYP27B1 | HGNC:2606 | 1 | 1 |
| HLA-DQB1 | HGNC:4944 | 1 | 1 |
| CNTF | HGNC:2169 | 1 | 1 |
| CD44 | HGNC:1681 | 1 | 1 |
| HTRA1 | HGNC:9476 | 1 | 1 |
| IL1B | HGNC:5992 | 1 | 1 |
| RAC2 | HGNC:9802 | 1 | 1 |
| GALC | HGNC:4115 | 1 | 1 |
| RPL5 | HGNC:10360 | 1 | 1 |
| GATA3 | HGNC:4172 | 1 | 1 |
| NGF | HGNC:7808 | 1 | 1 |
| NFKB1 | HGNC:7794 | 1 | 1 |
| OPA1 | HGNC:8140 | 1 | 1 |
| OPA3 | HGNC:8142 | 1 | 1 |
| OASL | HGNC:8090 | 1 | 1 |
| DOCK4 | HGNC:19192 | 1 | 1 |
| SNAP25 | HGNC:11132 | 1 | 1 |
| HLA-DQA1 | HGNC:4942 | 1 | 1 |
| IRF5 | HGNC:6120 | 1 | 1 |
| THRIL | HGNC:49503 | 1 | 1 |
| RPL9 | HGNC:10369 | 1 | 1 |
| AXL | HGNC:905 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| m.14484T>C | m.14484T>C | 2 | 2 |
| m.11778G>A | m.11778G>A | 1 | 1 |
| m.11778G>A | m.11778G>A | 1 | 1 |
| m.3460G>A | m.3460G>A | 1 | 1 |
| m.10237T>C | m.10237T>C | 1 | 1 |
| m.9101T>C | m.9101T>C | 1 | 1 |
| rs7975232 | rs7975232 | 1 | 1 |
| rs1544410 | rs1544410 | 1 | 1 |
| rs731236 | rs731236 | 1 | 1 |
| rs2228570 | rs2228570 | 1 | 1 |
| rs2476601 | rs2476601 | 1 | 1 |
| rs3135388 | rs3135388 | 1 | 1 |
| p.R389H | p.R389H | 1 | 1 |
| rs118204009 | rs118204009 | 1 | 1 |
| c.1156C>T | c.1156C>T | 1 | 1 |
| rs1971676214 | rs1971676214 | 1 | 1 |
| D173E | D173E | 1 | 1 |
| rs1242552448 | rs1242552448 | 1 | 1 |
| D173H | D173H | 1 | 1 |
| rs772570115 | rs772570115 | 1 | 1 |
| G176W | G176W | 1 | 1 |
| m.12308A>G | m.12308A>G | 1 | 1 |
| m.11467A>G | m.11467A>G | 1 | 1 |
| m.12372G>A | m.12372G>A | 1 | 1 |
| 10237T>C | 10237T>C | 1 | 1 |
| 15884G>C | 15884G>C | 1 | 1 |
| 9288A>G | 9288A>G | 1 | 1 |
| 14484T>C | 14484T>C | 1 | 1 |
| 15431G>A | 15431G>A | 1 | 1 |
| 8490T>C | 8490T>C | 1 | 1 |
| 5437C>T | 5437C>T | 1 | 1 |
| rs6604026 | rs6604026 | 1 | 1 |
| m.11150G>A | m.11150G>A | 1 | 1 |
| m.11519A>C | m.11519A>C | 1 | 1 |
| m.11523A>C | m.11523A>C | 1 | 1 |
| m.11527C>T | m.11527C>T | 1 | 1 |
| rs71624119 | rs71624119 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026The gut-brain axis: role of gut microbiota in neurological disease pathogenesis and pharmacotherapeutics.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Unraveling the metabolic potential of Moringa oleifera derived metabolites in combating Parkinson's and Alzheimer's disease.Bioorganic chemistry1 mentions
- 2026Built-environment correlates of physical activity in youth with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England)1 mentions
- 2026Setting priorities for how future research in multiple sclerosis in Canada considers equity, diversity and inclusion: A modified e-Delphi study.Multiple sclerosis journal - experimental, translational and clinical1 mentions
- 2026Causal association between multiple sclerosis and trigeminal neuralgia: A Mendelian randomization study with meta-analysis.Cranio : the journal of craniomandibular practice1 mentions
- 2026Effect of late-onset on multiple sclerosis phenotype and outcome: evidence from a multi-national registry.Journal of neurology1 mentions
- 2026Modulating the Gut Microbiome as a Therapeutic Approach in Multiple Sclerosis: Implications for Gut-Brain Interactions and Immune Pathways: A Narrative Review.Brain and behavior1 mentions
- 2026Adenosine A₂A receptor as a dual-acting molecular switch: Glial morphological changes and neurovascular tissue remodeling in neuroinflammation and neurodegeneration.Tissue & cell1 mentions
- 2026An Integrated Network Biology and Molecular Dynamics Approach Identifies CD44 as a Promising Therapeutic Target in Multiple Sclerosis.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2026Higher ultra-processed food consumption is associated with higher likelihood of paediatric-onset multiple sclerosis.Multiple sclerosis and related disorders1 mentions
- 2026Prevalence and predictive factors of epilepsy in multiple sclerosis: A cross-sectional study from Saudi Arabia.Multiple sclerosis and related disorders1 mentions
- 2026Identifying strategies to characterize the diversity of the MS population in Canada: a nominal group study.Frontiers in neurology1 mentions
- 2026Decoding the genetic basis of demyelination: Prediction of potential pathogenic coding and regulatory noncoding MBP SNPs in multiple sclerosis.PloS one1 mentions
- 2026Viral associations in multiple sclerosis: pathogenetic mechanisms and therapeutic implications.Virology journal1 mentions
- 2026Analysis of the comprehension and familiarity among the Saudi Arabian population regarding multiple sclerosis.Journal of family medicine and primary care1 mentions
- 2026Beyond categorical boundaries: Common molecular and cellular pathways in autism spectrum disorder and schizophrenia.Progress in neuro-psychopharmacology & biological psychiatry1 mentions
- 2026The many faces of the multiple sclerosis population in Canada.Multiple sclerosis and related disorders1 mentions
- 2026Genetic and molecular architecture of multiple sclerosis in gulf cooperation council populations: A scoping review and regional precision-neurology perspective.Multiple sclerosis and related disorders1 mentions
- 2026Clinical Characteristics of Multiple Sclerosis and Association of MS Severity with Vitamin D Level in the Madinah Region of Saudi Arabia: A Cross-Sectional Study.Neurosciences (Riyadh, Saudi Arabia)1 mentions
- 2026Obesity and Risk of Pediatric-Onset Multiple Sclerosis (POMS): a Systematic Review and Meta-Analysis.Maedica1 mentions
- 2025Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?Paediatric drugs1 mentions
- 2025Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c-Jun Pathway.Drug development research1 mentions
- 2025Abnormality of Voltage-Gated Sodium Channels in Disease Development of the Nervous System. A Review Article.CNS & neurological disorders drug targets1 mentions
- 2025Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management.Frontiers in chemistry1 mentions
- 2025Therapeutic potential of cannabinoids in neurological conditions: a systematic review of clinical trials.Frontiers in pharmacology1 mentions
- 2025Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review.Frontiers in pharmacology1 mentions
- 2025Associations between fronto-limbic white matter connections and internalizing symptoms in pediatric demyelinating disease.Multiple sclerosis and related disorders1 mentions
- 2025Glucose metabolism is controlled by non-coding RNAs in autoimmune diseases; a glimpse into immune system dysregulation.Human immunology1 mentions
- 2025Mitochondrial Uncoupler, 2,4-Dinitrophenol, Reduces Spinal Cord Paralysis and Retinal Ganglion Cell Loss in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.Biomolecules1 mentions
- 2025Characterizing the diversity of the multiple sclerosis population in Canada: A scoping review.Multiple sclerosis journal - experimental, translational and clinical1 mentions
- 2025Nano-healing: Exploring the Therapeutic Potentials of Nanomedicine for CNS Disorders.Current pharmaceutical design1 mentions
- 2025Cyclophosphamide as initial treatment of aggressive MS (Marburg variant) in resource limited settings - A case report.Clinical neurology and neurosurgery1 mentions
- 2025Emphasizing complementary in "Investigating the complementary value of OCT to MRI in cognitive impairment in relapsing-remitting multiple sclerosis".Multiple sclerosis (Houndmills, Basingstoke, England)1 mentions
- 2025Environmental and Familial Risk Factors for Multiple Sclerosis: Insights from a Saudi Arabian Cohort.Medicina (Kaunas, Lithuania)1 mentions
- 2025The janus face of astrocytes in multiple sclerosis: Balancing protection and pathology.Brain research bulletin1 mentions
- 2025Physical activity demonstrates protective associations with structural visual metrics in children with multiple sclerosis through time.Multiple sclerosis (Houndmills, Basingstoke, England)1 mentions
- 2025Cannabidiol as an immune modulator: A comprehensive review.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2025Clinical profile of seizures among multiple sclerosis patients in a tertiary care center.Multiple sclerosis and related disorders1 mentions
- 2025A Patient with Marburg's Variant of Multiple Sclerosis Responded Well to Cyclophosphamide.Annals of African medicine1 mentions
- 2025Potential therapeutic effects of ibudilast and retinoic acid against cuprizone-induced behavioral and biochemical changes in mouse brain.Frontiers in molecular neuroscience1 mentions
- 2025Unraveling the Role of THRIL/miR-137 in Fine-Tuning the Immunological Transcriptional Loop STAT4/STAT6/GATA3 in Multiple Sclerosis: Implications on Neurological Complications and Disease Subtypes.ACS chemical neuroscience1 mentions
- 2025Age of multiple sclerosis symptom onset affects mental and physical health-related quality of life in opposite directions.Multiple sclerosis and related disorders1 mentions
- 2025Dysregulation and gene polymorphisms of Vitamin D receptor: its implications in lipid metabolic disorders.Molecular biology reports1 mentions
- 2025Outcome of two siblings with late-onset Krabbe disease following allogeneic hematopoietic stem cell transplantation: And review of literature.Molecular genetics and metabolism reports1 mentions
- 2025From Molecules to Medicines: The Role of AI-Driven Drug Discovery Against Alzheimer's Disease and Other Neurological Disorders.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2025Access to therapy for children and adolescents with multiple sclerosis: global considerations in preventing disease progression.The Lancet. Child & adolescent health1 mentions
- 2025The Microbiota-Gut-Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders.CNS neuroscience & therapeutics1 mentions
- 2025Impact of the CYP27B1 p.R389H mutation on protein stability and function: implications for multiple sclerosis pathogenesis.Scientific reports1 mentions
- 2025IVIM-DWI-Based Radiomics for Lesion Phenotyping and Clinical Status Prediction in Relapsing-Remitting Multiple Sclerosis.Journal of clinical medicine1 mentions
- 2025A cross-sectional study investigating age of multiple sclerosis onset and its association with self-management knowledge and behaviors.Multiple sclerosis and related disorders1 mentions
- 2025A comprehensive overview of the effects of probiotics, prebiotics and synbiotics on the gut-brain axis.Frontiers in microbiology1 mentions
- 2025Multiple sclerosis pathophysiology: a comprehensive review of genetic, environmental, and immunological drivers.Inflammopharmacology1 mentions
- 2025Exploring the role of genetic variants in susceptibility to autoimmune Diseases: A molecular genetics approach.Human immunology1 mentions
- 2025Exploring the Neuroprotective Role of the Sulfonamide Derivative KM11 in Ethidium Bromide-induced Demyelination in Zebrafish Model Through Modulation of Antioxidant and Inflammatory Cytokine Pathways.Molecular neurobiology1 mentions
- 2025Mitochondrial-Immune Overlap in Leber Hereditary Optic Neuropathy: A Case Report and Lessons Learned.Reports (MDPI)1 mentions
- 2024Neuro-Behcet's disease misdiagnosed and treated as multiple sclerosis: a deceiving masquerader.The International journal of neuroscience1 mentions
- 2024Short-chain fatty acid producers in the gut are associated with pediatric multiple sclerosis onset.Annals of clinical and translational neurology1 mentions
- 2024Bridging autoimmunity and epigenetics: The influence of lncRNA MALAT1.Pathology, research and practice1 mentions
- 2024Potential clinical implications of molecular mimicry-induced autoimmunity.Immunity, inflammation and disease1 mentions
- 2024The Role of Gut-derived Short-Chain Fatty Acids in Multiple Sclerosis.Neuromolecular medicine1 mentions
- 2024Increased IL-22 in cerebrospinal fluid of neuro-behçet's disease patients.Cytokine1 mentions
- 2024Deciphering the Enigma of Neuron-Glial Interactions in Neurological Disorders.Frontiers in bioscience (Landmark edition)1 mentions
- 2024An Uncommon Coexistence of Ischemic Stroke in a Multiple Sclerosis Patient With Duplicated Superior Cerebellar Artery: A Case Report From Saudi Arabia.Cureus1 mentions
- 2024Tepilamide Fumarate as a Novel Potentiator of Virus-Based Therapy.Viruses1 mentions
- 2024Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits.Ageing research reviews1 mentions
- 2024Tumefactive demyelinating lesions: A literature review of recent findings.Neurosciences (Riyadh, Saudi Arabia)1 mentions
- 2024FTY720 Reduces the Biomass of Biofilms in Pseudomonas aeruginosa in a Dose-Dependent Manner.Antibiotics (Basel, Switzerland)1 mentions
- 2024A Comprehensive Review of Leber Hereditary Optic Neuropathy and Its Association with Multiple Sclerosis-Like Phenotypes Known as Harding's Disease.Eye and brain1 mentions
- 2024circRNAs as Epigenetic Regulators of Integrity in Blood-Brain Barrier Architecture: Mechanisms and Therapeutic Strategies in Multiple Sclerosis.Cells1 mentions
- 2024Multiple sclerosis and amyotrophic lateral sclerosis: is there an association or a red flag? A case report and literature review.BMC neurology1 mentions
- 2024Social network characteristics and their relationships with physical activity in children with multiple sclerosis.Multiple sclerosis and related disorders1 mentions
- 2024Interplays Between Matrix Metalloproteinases and Neurotropic Viruses: An Overview.Reviews in medical virology1 mentions
- 2024Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation1 mentions
- 2024Establishing consensus on lifestyle recommendations and behaviour change strategies to promote brain health-focussed care for multiple sclerosis: A modified e-Delphi study.Multiple sclerosis and related disorders1 mentions
- 2024Need for neurorehabilitation in the Middle East and North Africa from 1990 to 2021: an analysis based on the global burden of disease study.Annals of medicine and surgery (2012)1 mentions
- 2024Management and outcomes of pediatric optic neuritis in a tertiary hospital in Riyadh, Saudi Arabia: a retrospective study.BMC neurology1 mentions
- 2024Corneal Confocal Microscopy Identifies and Differentiates Patients With Multiple Sclerosis and Epilepsy.Translational vision science & technology1 mentions
- 2024Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis.Frontiers in molecular neuroscience1 mentions
- 2023Diagnosis and treatment of progressive multiple sclerosis: A position paper.European journal of neurology1 mentions
- 2023CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.Human genetics1 mentions
- 2023Magnetization transfer saturation reveals subclinical optic nerve injury in pediatric-onset multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England)1 mentions
- 2023Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis.European journal of neurology1 mentions
- 2023Experience and perception of utilizing virtual clinic in neurological assessment in Saudi Arabia.Frontiers in neurology1 mentions
- 2023Online Health Information Seeking by Individuals With Physical Disabilities Caused by Neurological Conditions in Saudi Arabia.Cureus1 mentions
- 2023Probiotic-Fermented Camel Milk Attenuates Neurodegenerative Symptoms via SOX5/miR-218 Axis Orchestration in Mouse Models.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2023Molecular insights into the pathogenic impact of vitamin D deficiency in neurological disorders.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1 mentions
- 2023Nogo receptor-Fc delivered by haematopoietic cells enhances neurorepair in a multiple sclerosis model.Brain communications1 mentions
- 2023Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): A challenging diagnosis and a rare multiple sclerosis mimic.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association1 mentions
- 2023The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles.International immunopharmacology1 mentions
- 2023Medication Adherence Status and Its Association With Quality of Life Among Individuals With Neurological Conditions in Saudi Arabia.Cureus1 mentions
- 2023The small molecule Erk1/2 signaling pathway inhibitor PD98059 improves DNA repair in an experimental autoimmune encephalomyelitis SJL/J mouse model of multiple sclerosis.Mutation research. Genetic toxicology and environmental mutagenesis1 mentions
- 2023Exploring the impact of miR-128 in inflammatory diseases: A comprehensive study on autoimmune diseases.Pathology, research and practice1 mentions
- 2023Multiple Sclerosis-A Demyelinating Disorder and Its Dental Considerations-A Literature Review with Own Case Report.Brain sciences1 mentions
- 2023The protective effects of sesamol and/or the probiotic, Lactobacillus rhamnosus, against aluminum chloride-induced neurotoxicity and hepatotoxicity in rats: Modulation of Wnt/β-catenin/GSK-3β, JAK-2/STAT-3, PPAR-γ, inflammatory, and apoptotic pathways.Frontiers in pharmacology1 mentions
- 2023Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities.Biomolecules1 mentions
- 2023DNA Methylation Signatures of Multiple Sclerosis Occur Independently of Known Genetic Risk and Are Primarily Attributed to B Cells and Monocytes.International journal of molecular sciences1 mentions
- 2023The microRNAs (miRs) overexpressing mesenchymal stem cells (MSCs) therapy in neurological disorders; hope or hype.Biotechnology progress1 mentions
- 2023Exploring the Role of Plasma Lipids and Statin Interventions on Multiple Sclerosis Risk and Severity: A Mendelian Randomization Study.Neurology1 mentions
- 2023Metabolite Alterations in Autoimmune Diseases: A Systematic Review of Metabolomics Studies.Metabolites1 mentions
- 2023Sleep, physical activity, and psychological outcomes in children and adolescents with pediatric onset multiple sclerosis.Multiple sclerosis and related disorders1 mentions