Population record
· 78 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| population | Population | “The region of the Americas carried the highest foodborne chemical DALY rate in children younger than 5 years, with 749 DALYs (435-1260) per 100 000 children, mainly due to the effect of methylmercury on intellectual disability (91·0%).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “MR studies included over one million participants, while cross-sectional studies involved over 43,000 participants, and the cohort studies included 421 migraine cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “To evaluate the current status and guide future interventions, we present the latest epidemiological estimates of enteric infectious diseases from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 and assess progress towards the Global Action Plan for the Prevention and Control of Pneumonia and Diarrhoea (GAPPD) mortality target of fewer than 20 deaths per 100 000 children younger than 5 years by 2025.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “RESULTS: Nine RCTs, including 4,000 participants, met eligibility criteria.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “It is estimated that approximately 100,000 new cases of melanoma were diagnosed in 2022, resulting in over 7600 deaths in the United States alone.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “FINDINGS: Globally, in 2023, there were an estimated 377 000 incident childhood cancer cases (95% UI 288 000-489 000), 144 000 deaths (131 000-162 000), and 11·7 million (10·7-13·2) DALYs due to childhood cancer.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The four WHO-defined preventable meningitis pathogens of interest (S pneumoniae, N meningitidis, Haemophilus influenzae, and Group B streptococcus) contributed to 98 700 deaths (77 000-127 000) and 594 000 cases (514 000-686 000).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The estimated incidence is around 1:10,000 children per year.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Progress was assessed towards the GAPPD target of less than three deaths from pneumonia per 1000 livebirths, which is roughly equivalent to a mortality rate of less than 60 deaths per 100 000 children younger than 5 years.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “A cohort of over 15,000 patients has provided clinical evidence showing an important correlation between high levels of serum TK1 and tumor burden, disease stage, and treatment response in hematology and solid tumors.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “This search yielded randomized controlled trials, which together enrolled over 60,000 participants between the ages of 70 and 84.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Statistical analyses were conducted to calculate age-adjusted mortality rates (AAMRs) per 100,000 individuals and annual percent changes with 95% confidence intervals (CIs).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Age-adjusted mortality rates (AAMRs) were calculated per 100,000 individuals using the 2000 U.S. standard population.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Materials and Methods: A comprehensive dataset comprising 10,000 patient records with 12 clinical and demographic features was utilized.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In addition, around 500,000 infants are born with SCD and 60,000 people are diagnosed with BT every year.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The CDC has designated it as an underdiagnosed, serious, and potentially preventable disorder, contributing to an estimated 600,000-900,000 cases and 100,000 deaths annually in the United States.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Melanoma, a globally prevalent skin cancer with over 325,000 new cases annually, necessitates a comprehensive under- standing of its molecular components.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “BACKGROUND: Cervical cancer is the fourth most frequent cancer in women worldwide, with an expected 604,000 new cases and 342,000 deaths in 2020.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The unprecedented global spread of Clade IIb Mpox in 2022, affecting over 99,000 individuals across 118 countries, underscored the potential for widespread transmission beyond endemic regions.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Serum levels of progesterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were significantly elevated in the BEON0.5 and BEON1.0 groups compared to the control group (P < 0.01).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The framework was evaluated using two distinct datasets: MIMIC-IV, a critical care database containing clinical data of critically ill patients, and the UK Biobank, which comprises genetic, clinical, and lifestyle data from 500,000 participants.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Eight lines of foxtail millet; U2, V19, V73, V93, V101, V106, V107, and V111, were under study along with NPK fertilizers' treatments; T1 = 000 NPK as a control, T2 = 20:15:15 NPK, T3 = 30:20:20 NPK, T4 = 40:25:25 NPK, and T5 = 50:30:30 NPK (kg ha- 1).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We used a standard thyroid-balanced dataset containing 7,000 patient records to apply advanced machine-learning methods.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Thyroid cancer (TC) is the most common endocrine cancer, which contributes to more than 43,600 deaths and 586,000 cases worldwide every year.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Globally, this particular cancer ranks sixth in prevalence, resulting in an annual mortality rate above 325,000 individuals.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Hepatocellular carcinoma (HCC) affects approximately 800,000 individuals globally each year.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Up to 30,000 patients will be included from up to 50 international multi-continental clinical CCTA sites and followed for 3-4 years.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Positive correlation exists between maternal age, particularly in advanced cases, and the global annual incidence is over 200,000 cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The toughness of CBM3-BC films reached 7.9, 28.0, 13.3, and 13.6 MJ/m3, which were 6.1, 1.3, 1.4, and 3.0 folds over the control for conditions of dry, wet, acidic, and basic, respectively.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “For example, in the European Union and North America only 35,000 and 22,000 cases, respectively, will require anti-HDV testing annually.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “INTRODUCTION: The current monkeypox (MPX) outbreak, caused by the monkeypox virus (MPXV), has turned into a global concern, with over 59,000 infection cases and 23 deaths worldwide.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The study plans to recruit 1,000 adults aged ≥18 years following ischemic stroke from participating hospitals over 12 months.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In general, the estimated prevalence of this condition is one in 15,000-20,000 individuals.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The prevalence of PKU varies widely among ethnicities and geographic regions, affecting approximately 1 in 24,000 individuals worldwide.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: Exome/genome sequencing and human phenotype ontology data of nearly 40 000 patients from our Bio/Databank were analysed.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Through a search of our bio/databank with information from genetic testing of >55 000 individuals, we identified nine additional patients from seven families with six novel homozygous ZNFX1 variants.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “According to a survey of the United States of America, there are more than 17,000 sarcoma patients registered each year which is 15% of all cancer cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Tetralogy of Fallot (TOF) is the most prevalent cyanotic congenital cardiac abnormality, affecting three out of every 10,000 live infants with a prevalence rate of 5-10% of all congenital cardiac defects.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “According to a survey within the United States of America, there are more than 282,000 breast adenocarcinoma patients registered each 12 months, and most of them are women.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “According to the United States of America survey, more than 282,000 breast cancer patients are registered each year; most of them are women.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We performed gene-based association testing of blood lipid levels with rare (minor allele frequency < 1%) predicted damaging coding variation by using sequence data from >170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African, 16,440 Hispanic/Latino, 10,420 East Asian, and 1,182 Samoan.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most prevalent cancer worldwide, with an annual incidence of 600,000 new cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “RESULTS: The number of digoxin users in the USA declined by 47% from 766 users per 100,000 adults in 2010-11 to 402 users per 100,000 adults in 2016-17.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “UC is a well-known health challenge affecting 200-250 per 100 000 individuals worldwide, with a similar prevalence in both sexes and elevated upon activation of gut immune responses.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS/DESIGN: This is a cross-sectional study that will use the UK Biobank database, which will include a subset of 381,000 participants: males and females aged 50 years and above who completed the baseline assessments.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “During this study period, 25,000 hard adult ticks of Hyalomma species were collected from freshly slaughtered imported camels to determine the presence of Crimean-Congo hemorrhagic fever virus (CCHFV) and genetic lineage of the virus.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Surprisingly, the coexistence of both distinct common clinical conditions is extremely rare, and it is thought that the incidence of polycystic HSK varies from one in 134,000 to one in 8,000,000 cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Sickle cell disease (SCD) affects more than 300,000 children annually worldwide.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The incidence of MDR-iNTS disease exceeded 100/100 000 person-years-of-observation in children aged <5 years in several West African countries.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Gene-disease association was assessed using our data repository that combines ES/GS data and Human Phenotype Ontology terms from over 33,000 patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Aphallia is mostly described in males with a frequency of less than one per 40 000 male newborns.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Health-Related Quality of Life and Mortality in Heart Failure: The Global Congestive Heart Failure Study of 23 000 Patients From 40 Countries.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS AND ANALYSIS: We have designed an international inception cohort study including at least 1,000 consecutive adult patients acutely admitted to the ICU without prior history of persistent or permanent AF.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Inborn errors of mitochondrial fatty acid oxidation (FAO) comprise the most common group of disorders identified through expanded newborn screening mandated in all 50 states in the United States, affecting 1:10,000 newborns.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “This study, which aggregated data from >18,000 individuals who underwent gene panel or exome testing for inherited cardiomyopathies, identified 32 probands with VCL loss-of-function variants and confirmed enrichment in probands with dilated cardiomyopathy (odds ratio [OR] = 9.01; confidence interval [CI] = 4.93-16.45).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Patients aged >7 years completed the HEAR-QL-26, HEAR-QL-28, and PedsQL 4.0 self-report tool, while parents completed the PedsQL 4.0 parent proxy report for children aged ≤7 years.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Background: With a prevalence of 170 000 adults in the US alone, meningiomas are the most common primary intracranial tumors.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Outcome of ambulatory video-EEG monitoring in a ˜10,000 patient nationwide cohort.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “However, there were no significant differences between WBA measured at TPP and 0 daPa for infants from 3 to 6 months of age.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In 2017, the year of its inauguration and the first year of operation, the Magrabi ICO Cameroon Eye Institute provided ophthalmology subspecialty care to more than 25 000 patients and surgery for pediatric and adult cataract, glaucoma, retinal disease, oculoplastic disorders, and other vision-threatening conditions.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Assessment The 31 of 37 HTCs responding served over 10,000 individuals, or one-third of the national HTC patient population.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Exome-wide association study of plasma lipids in >300,000 individuals.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Hereditary factor X (FX) deficiency affects 1:500 000 to 1:1 000 000 individuals, and no specific replacement FX concentrate has been available.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “PURPOSE: Retinoblastoma (RB) is a rare intraocular malignant tumor of the developing retina with an estimated incidence of 1:20,000 live births in children under the age of 5 years.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The largest viraemic populations were in Pakistan (7 001 000 cases) and Indonesia (3 187 000 cases).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Through sequencing or genotyping of ~150,000 individuals across 5 ancestry groups, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.Trp325Arg) associated with T2D risk and glucose and proinsulin levels.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The prevalence of DS is 3-6% of epilepsy cases in infancy, and the incidence is less than one per 40,000 infants.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The incidence of CDSP varies depending on ethnicity; however the frequency in the United States is estimated to be approximately 1 in 50,000 individuals based on newborn screening data.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Leptospirosis, a zoonosis of global importance and it is underreported in India and more than 50,000 severe cases are reported each year.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “There may be up to 82,000 children with non-traumatic cataract in Africa, with approximately 19,000 new cases each year.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “If the true efficacy of 4RMP is ≥75%, a trial powered to detect non-inferiority with a lower limit of 60% estimated efficacy (~20 000 subjects) may lead to cost savings within 10 years, even with the extreme assumption that Canada bears the entire cost.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The estimated incidence in childhood is approximately 20 per 100,000 children per year.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In a comprehensive screening and educational programme, we tested around 34,000 infants for G6PD deficiency.” | 0.80 | saudi_context_rules_v1 |