HMGB1
HGNC:4983 · 34 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HMGB1 | “HMGB1 regulation was linked to genomic instability and metastasis, yet it showed potential protective effects in survival analyses.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “SNPs in genes related to inflammation (e.g., TNF-α, HMGB1), lipid metabolism (ANGPTL4, DIAPH1), oxidative stress (MTHFR), and regulatory RNAs (MIAT, microRNAs) were associated with stroke susceptibility, subtype-specific risk, post-stroke recovery, or recurrence.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Nephroprotective Potential of Tectorigenin Against Thiamethoxam Instigated Renal Toxicity Via Regulating HMGB1/RAGE, TLR4/MyD88, and NF-κB Pathway in Sprague Dawley Rats: An In-Vivo and In-Silico Investigation.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Results: NiSO4 exposure induced marked hepatic injury, evidenced by reduced body weight, adverse serum biochemical profiles, increased hepatic enzymes and bilirubin, elevated oxidative damage markers (MDA, protein carbonyls), increased proinflammatory cytokines, and upregulation of HMGB1, PI3K, mTOR, JAK/STAT, and proapoptotic genes, accompanied by aberrant nickel accumulation and severe histopathological alterations.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “HMGB1/NF-κB Axis, IL-8, and Cuproptosis Contribute to Cisplatin-Induced Testicular Injury: Protective Potential Effect of Thymol.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Estimating high mobility group box protein 1 (HMGB1) single nucleotide polymorphisms among hepatitis B virus infected patients of Pakistan origin.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Neuroprotective potential of fortunellin against titanium dioxide nanoparticles induced neurotoxicity via regulating NLRP3, HMGB1/RAGE, and NF-κB pathway: A biochemical, histological and in-silico experimentation.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Platelet-rich plasma enhances remodeling of combined gastrocnemius muscle and Achilles tendon injuries in rat model: Reducing fibrosis, modulating gene (MMP9, Bax, HMGB1, and IGF) expression, and restoring histopathological and ultrastructural changes.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Gut microbiota-derived TMAO and SIRT1/HMGB1 Axis: unveiling mechanisms of renal impairment in beta-thalassemia major.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Pharmacotherapeutic potential of artemetin against amiodarone instigated sub-chronic hepatotoxicity via modulating TLR4/HMGB1/RAGE and NF-κB signaling pathways: An in-vivo and in-silico approach.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Retraction notice to "Ameliorative effects of vanillin against pentylenetetrazole-induced epilepsy and associated memory loss in mice: The role of Nrf2/HO-1/NQO1 and HMGB1/RAGE/TLR4/NFκB pathways" [Int.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “All treatments remarkably improved MSG-induced abnormalities in neurotransmitters' levels; biochemical markers; along with histological findings, via modulating HMGB1/RAGE/JAK-2/STAT-3, PI3K/AKT/CREB/BDNF, AMPK/SIRT-1 and PERK/CHOP pathways.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Treatment resulted in substantial reductions in key inflammatory markers, including HMGB1, RAGE, TLR4 expression, NFκB activity, pro-inflammatory cytokines (TNF-α and IL-6), and apoptosis marker caspase-3.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Pharmacotherapeutic role of astringin against chromium induced nephrotoxicity via modulating TLR4/MyD88, HMGB1/RAGE and NF-κB pathway: A biochemical and pharmacokinetic approach.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Nephroprotective potential of robinin to counteract aldicarb induced renal dysfunction via modulating TLR4/MyD88, HMGB1/RAGE, NF-κB pathway: A biochemical and pharmacodynamic approach.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Special emphasis is placed on the most recent findings related to key proteins such as TREM2 (triggering receptor expressed on myeloid cells 2) and HMGB1 (high mobility group box 1 protein).” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Alirocumab boosts antioxidant status and halts inflammation in rat model of sepsis-induced nephrotoxicity via modulation of Nrf2/HO-1, PCSK9/HMGB1/NF-ᴋB/NLRP3 and Fractalkine/CX3CR1 hubs.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Additionally, it decreased the expression of high motility group box protein 1 (HMGB1), toll-like receptor 4 (TLR4), nuclear factor kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and NOD-like receptor (NLR) Family Pyrin Domain Containing 3 (NLRP3) inflammasome in the pancreas.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “The immunoreactivity of PCNA and HMGB1 was examined immunohistochemically.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Unlocking the miRNA-34a-5p/TGF-β and HMGB1/PI3K/Akt/mTOR crosstalk participate in the enhanced cardiac protection of liraglutide against isoproterenol-induced acute myocardial injury rat model.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Ameliorative effects of vanillin against pentylenetetrazole-induced epilepsy and associated memory loss in mice: The role of Nrf2/HO-1/NQO1 and HMGB1/RAGE/TLR4/NFκB pathways.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Rutin is a natural flavonoid with many pharmacological activities and its role in acetic acid-induced ulcerative colitis through the high mobility group B1 (HMGB1)/ toll-like receptor-4 (TLR4)/ myeloid differentiation primary response protein 88 (MYD88)/ nuclear factor-kB (NF-kB) signaling pathway needs to be explored.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “The immunological (IKBKG, LGALS, IL1B, CCL2, RANTES, MASP2, HMGB1, and S-LZ) genes' nucleotide sequence differences between healthy buffaloes and buffaloes affected by inflammatory reproductive diseases were found by employing PCR-DNA sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Dual luciferase reporter gene and RNA immunoprecipitation assays were carried out to verify the interaction between miR-340-5p and HMGB1.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Anethole reduced gene and protein expression levels of HMGB1, TLR2, TLR4, MYD88, and NFκB.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “High cytokine levels (IL-1β, IL-6, IFN-α, GM-CSF, and HMGB1) were observed acutely in the MIS-C children, and a persistent elevation of some cytokines were reported at midterm follow-up, especially in Group B.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Oleanolic acid interacted with the proteins AKR1B10, CASP3, CASP8, CYP1A2, CYP1A2, HMGB1, NAMPT, NFE2L2, NQO1, PPARA, PTGIR, TOP1, TOP2A, UGT2B10, and UGT2B11 and stigmasterol with ABCA1, ABCG5, ABCG8, CTSE, HMGCR, IL10, CXCL8, NR1H2, NR1H3, SLCO1B1, SREBF2, and TNF.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Celecoxib Decrease Seizures Susceptibility in a Rat Model of Inflammation by Inhibiting HMGB1 Translocation.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Notably, no former studies have linked JAK2/STAT3, HMGB1/NF-κB, and Nrf2/HO-1 signaling in TNBS-evoked colitis.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Moreover, a significant upregulation of gene and protein expressions of TLR4, NF-κB, and high-mobility group box-1 (HMGB1) along with caspase-3 protein expression was observed in the HIR group when compared with the sham group.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “Cardiomyocyte-fibroblast interaction contributes to diabetic cardiomyopathy in mice: Role of HMGB1/TLR4/IL-33 axis.” | 0.98 | hgnc_dict_v1 |
| gene | HMGB1 | “PURPOSE: The expression of high-mobility group box-1 (HMGB1) is upregulated in epiretinal membranes and vitreous fluid from patients with proliferative diabetic retinopathy and in the diabetic retina.” | 0.98 | hgnc_dict_v1 |