MDM2
HGNC:6973 · 34 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MDM2 | “MDM2 gene amplification in surgical pathology: biology, diagnostic utility, and clinical relevance in the modern era.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Murine double minute 2 (MDM2) as an appealing target for natural products in cancer treatment.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Beyond MDM2 amplification: chromosomal translocations as diagnostic drivers in adipocytic tumours-a histopathological and molecular reappraisal.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “However, novel therapeutic approaches provide promising avenues, including MDM2 inhibitors, p53-reactivating agents, pathway-targeted inhibitors (Hedgehog, Wnt, NF-κB), immune modulation (checkpoint inhibitors, CAR-T therapy), metabolic interventions (fatty acid metabolism, glycolysis), and gene-editing technologies (CRISPR/Cas9, base editing).” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Four constituents of A. alba-Avicenol B, Avicenol C, Avicequinone B, and Avicequinone C-were verified, leading to the identification of 10 hub genes (i.e., EGFR, PIK3CA, JAK2, MTOR, JUN, ERBB2, IGF2, SRC, MDM2, and PARP1) associated with CRC.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “To address this issue, advances have been made in therapies targeting molecular pathways related to the murine double minute 2 proto-oncogene (MDM2)-tumor proteinp53 (TP53) interaction.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Molecular analyses revealed no MDM2 amplification and excluded EBV infection.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Anticancer activity of MDM2 inhibition in 2D and bioprinted 3D retinoblastoma cell models.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Diagnosis was confirmed using fluorescence in situ hybridization (FISH) for MDM2 gene amplification, emphasizing the importance of molecular diagnostic testing in such complex cases.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “This study evaluated ethosomes as a novel nanodelivery system for nutlin-3a, a known MDM2 inhibitor and activator of the p53 pathway, to improve nutlin-3a's poor solubility, limiting its bio-distribution and therapeutic efficacy.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Ubiquitin-specific protease-7 (USP7) is an important drug target as it regulates multiple proteins and genes (such as MDM2 and p53) with roles in cancer progression.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Genotypes at three SNPs, rs1799883 in FABP2, rs3813865 in CYP2E1, and rs1042522 in TP53, were found to be associated with the development of CRC, while rs1042522 in MDM2 was not.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Assessment of MDM2 Gene Locus Amplification by Fluorescence In-Situ Hybridization in Juvenile Ossifying Fibroma.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Additionally, we explored the binding affinity of spirooxindole analogs, particularly compound 6d, to MDM2, a protein involved in regulation of p53.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Corrigendum to "Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators" [Bioorg.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “The adopted design rationale and synthetic routes relied on mimicking the general thematic features of lead MDM2 inhibitors incorporating multiple aromatic rings.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development Approach.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “MDM2 inhibitors-mediated disruption of mitochondrial metabolism: A novel therapeutic strategy for retinoblastoma.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Enhancement of MDM2 inhibitory effects through blocking nuclear export mechanisms in ovarian cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Murine Double Minute 2 Gene (MDM2) rs937283A/G variant significantly increases the susceptibility to breast cancer in Saudi Women.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “The tumor suppressor gene TP53 and its downstream genes P21 and MDM2 play crucial roles in combating DNA damage at the G1/S cell cycle checkpoint.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “PURPOSE: Mouse double minute 2 (MDM2) homolog is a protein that in humans is encoded by the MDM2 gene.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Genetic polymorphisms of TP53 (rs1042522) and MDM2 (rs2279744) and colorectal cancer risk: An updated meta-analysis based on 59 case-control studies.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “On the other hand, the murine double minute 2 (MDM2) oncogene protein is an important cellular antagonist of p53.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Dysfunction of the MDM2/p53 axis is linked to premature aging.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “In addition to confirming known genes of OSCC (TP53, CDKNA2, CASP8, PIK3CA, HRAS, FAT1, TP63, CCND1 and FADD) the analysis identified several candidate novel driver events including mutations of NOTCH3, CSMD3, CRB1, CLTCL1, OSMR and TRPM2, amplification of the proto-oncogenes FOSL1, RELA, TRAF6, MDM2, FRS2 and BAG1, and deletion of the recently described tumor suppressor SMARCC1.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “In tumours that harbour wild-type p53, p53 protein function is frequently disabled by the mouse double minute 2 protein (MDM2, or HDM2 in humans).” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “MDM2 (RS769412) G>A Polymorphism in Cigarette Smokers: a Clue for the Susceptibility to Smoking and Lung Cancer Risk.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “The aim of this study was to investigate the association between 10 SNPs in genes involved in cell cycle control and DNA repair (p21 C31A, p53 G72C, ATM G1853A, XRCC1 G399A, XRCC3 C241T, Ku80 A2790G, DNA Ligase IV C9T, DNA-PKcs A3434G, TGF-beta T10C, MDM2 promoter T309G) and the risk to develop head and neck cancer.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “The tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in carcinogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “Multiple different oncogenes have been described previously to be amplified in breast cancer including HER2, EGFR, MYC, CCND1, and MDM2.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “The expression of the MDM2 gene, a p53 binding protein, in thyroid carcinogenesis.” | 0.98 | hgnc_dict_v1 |