coronary artery disease
SaudiVarKB evidence summary derived from retained literature mentions.
276Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| LDLR | HGNC:6547 | 8 | 8 |
| ACE | HGNC:2707 | 6 | 6 |
| MTHFR | HGNC:7436 | 5 | 5 |
| PCSK9 | HGNC:20001 | 4 | 4 |
| PON1 | HGNC:9204 | 4 | 4 |
| APOE | HGNC:613 | 3 | 3 |
| TG | HGNC:11764 | 3 | 3 |
| APOB | HGNC:603 | 3 | 3 |
| CDKN2B | HGNC:1788 | 3 | 3 |
| CETP | HGNC:1869 | 3 | 3 |
| CDKN2A | HGNC:1787 | 3 | 3 |
| ACE2 | HGNC:13557 | 3 | 3 |
| LPL | HGNC:6677 | 2 | 2 |
| APOA5 | HGNC:17288 | 2 | 2 |
| STAT3 | HGNC:11364 | 2 | 2 |
| CBS | HGNC:1550 | 2 | 2 |
| TCF7L2 | HGNC:11641 | 2 | 2 |
| JAK2 | HGNC:6192 | 2 | 2 |
| ABCA1 | HGNC:29 | 2 | 2 |
| APOA1 | HGNC:600 | 2 | 2 |
| AGT | HGNC:333 | 2 | 2 |
| GSTT1 | HGNC:4641 | 2 | 2 |
| HNF1A | HGNC:11621 | 2 | 2 |
| CDKN2B-AS1 | HGNC:34341 | 2 | 2 |
| PNPLA3 | HGNC:18590 | 2 | 2 |
| MEF2A | HGNC:6993 | 2 | 2 |
| PAH | HGNC:8582 | 1 | 1 |
| MVP | HGNC:7531 | 1 | 1 |
| NLRP3 | HGNC:16400 | 1 | 1 |
| AK2 | HGNC:362 | 1 | 1 |
| SCN10A | HGNC:10582 | 1 | 1 |
| KCNQ1 | HGNC:6294 | 1 | 1 |
| COMT | HGNC:2228 | 1 | 1 |
| KLF14 | HGNC:23025 | 1 | 1 |
| GIPR | HGNC:4271 | 1 | 1 |
| HLA-DRB1 | HGNC:4948 | 1 | 1 |
| GSK3B | HGNC:4617 | 1 | 1 |
| CYP2C19 | HGNC:2621 | 1 | 1 |
| GLIS3 | HGNC:28510 | 1 | 1 |
| H19 | HGNC:4713 | 1 | 1 |
| SPG7 | HGNC:11237 | 1 | 1 |
| SYNE1 | HGNC:17089 | 1 | 1 |
| MALAT1 | HGNC:29665 | 1 | 1 |
| HLA-B | HGNC:4932 | 1 | 1 |
| ABO | HGNC:79 | 1 | 1 |
| INS | HGNC:6081 | 1 | 1 |
| CCR5 | HGNC:1606 | 1 | 1 |
| GATA2 | HGNC:4171 | 1 | 1 |
| MAF | HGNC:6776 | 1 | 1 |
| VDR | HGNC:12679 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| C677T | C677T | 2 | 2 |
| rs4646994 | rs4646994 | 2 | 2 |
| G20210A | G20210A | 2 | 2 |
| Q192R | Q192R | 2 | 2 |
| rs2274907 | rs2274907 | 2 | 2 |
| rs2274908 | rs2274908 | 2 | 2 |
| rs1801133 | rs1801133 | 1 | 1 |
| rs6505162 | rs6505162 | 1 | 1 |
| c.335_336insCGAG | c.335_336insCGAG | 1 | 1 |
| p.F114Rfs | p.F114Rfs | 1 | 1 |
| c.622G>A | c.622G>A | 1 | 1 |
| p.E208K | p.E208K | 1 | 1 |
| c.1474G>A | c.1474G>A | 1 | 1 |
| p.D492N | p.D492N | 1 | 1 |
| c.1429G>A | c.1429G>A | 1 | 1 |
| p.D477N | p.D477N | 1 | 1 |
| c.1421C>G | c.1421C>G | 1 | 1 |
| p.S474* | p.S474* | 1 | 1 |
| rs1800629 | rs1800629 | 1 | 1 |
| rs1056827 | rs1056827 | 1 | 1 |
| rs1801131 | rs1801131 | 1 | 1 |
| p.Y419D | p.Y419D | 1 | 1 |
| p.S202Tfs | p.S202Tfs | 1 | 1 |
| rs4680 | rs4680 | 1 | 1 |
| Q192R | Q192R | 1 | 1 |
| rs1805087 | rs1805087 | 1 | 1 |
| rs662 | rs662 | 1 | 1 |
| rs5742905 | rs5742905 | 1 | 1 |
| rs1558861 | rs1558861 | 1 | 1 |
| rs780094 | rs780094 | 1 | 1 |
| rs10911205 | rs10911205 | 1 | 1 |
| rs17145738 | rs17145738 | 1 | 1 |
| rs6982502 | rs6982502 | 1 | 1 |
| rs662 | rs662 | 1 | 1 |
| G1691A | G1691A | 1 | 1 |
| rs3741596 | rs3741596 | 1 | 1 |
| S218G | S218G | 1 | 1 |
| rs10757278 | rs10757278 | 1 | 1 |
| rs12248560 | rs12248560 | 1 | 1 |
| p.I27L | p.I27L | 1 | 1 |
| rs1169288 | rs1169288 | 1 | 1 |
| rs1695 | rs1695 | 1 | 1 |
| rs7903146 | rs7903146 | 1 | 1 |
| rs217727 | rs217727 | 1 | 1 |
| rs4646994 | rs4646994 | 1 | 1 |
| rs1562902 | rs1562902 | 1 | 1 |
| rs12255372 | rs12255372 | 1 | 1 |
| rs333 | rs333 | 1 | 1 |
| rs599839 | rs599839 | 1 | 1 |
| rs2910164 | rs2910164 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026The Potential Protective Effect of Carvedilol on Induced Myocardial Ischemia-Reperfusion Injury in Rats: A Histological and Immunohistochemical Study.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada1 mentions
- 2026Whole-exome sequencing in obstructive coronary artery disease identifies rare and novel variants in cardiac arrhythmia and pulmonary arterial hypertension-associated genes.Biomolecules & biomedicine1 mentions
- 2026Hypoxia-inducible factor-1α in cardiovascular disease, mechanistic insights, pathophysiological roles, and therapeutic targeting strategies.Biochemical pharmacology1 mentions
- 2026National Heart Center/Saudi Heart Association 2025 Guidelines for Cardiovascular Diseases Prevention and Risk Assessment.Saudi medical journal1 mentions
- 2026Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma.The Journal of clinical investigation1 mentions
- 2026A rare ORAI1 missense variant associates with risk of vascular diseases in White British adults.PloS one1 mentions
- 2026Potential cardioprotective and regenerative effects of the fluorinated benzothiazole derivative AS09 in the myocardial infarction-induced zebrafish.Biochimie1 mentions
- 2026Mesenchymal stem cell-conditioned media alleviates diabetic cardiomyopathy by modulating glycemic control, oxidative stress-induced injury and inflammation regulation.Journal of diabetes and metabolic disorders1 mentions
- 2026Metabolic therapy for cardiovascular diseases with propionyl L-carnitine.Canadian journal of physiology and pharmacology1 mentions
- 2026Characterization of biomarker profiles in patients with coronary artery disease: A prospective coronary computed tomography angiography study.American heart journal1 mentions
- 2026Giant Dedifferentiated Liposarcoma of the Mediastinum.Annali italiani di chirurgia1 mentions
- 2026Traditional cardiovascular risk factors and their association with atherosclerotic cardiovascular disease in homozygous familial hypercholesterolemia: A cross-sectional analysis from the HICC registry.Atherosclerosis1 mentions
- 2026Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990-2023: a Global Burden of Disease study.Nature medicine1 mentions
- 2026Cardiac safety of sofosbuvir-based direct-acting antivirals in hepatitis C patients with pre-existing heart disease.Clinics (Sao Paulo, Brazil)1 mentions
- 2026Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition.Frontiers in physiology1 mentions
- 2026Hospital-Based Proportion of Diabetic Retinopathy and Associated Risk Factors Among Patients With Type 2 Diabetes Mellitus.Cureus1 mentions
- 2026Erratum to "The Association between Inflammatory Bowel Disease and Ischemic Heart Disease: A Retrospective Cohort Study" [Saudi Medical Journal 2025 Oct; 46(10):1174-1181].Saudi medical journal1 mentions
- 2026Childhood Obesity: Global Burden, Multifactorial Etiologies, Biological Mechanisms, and Emerging Interventions for Prevention and Management.Saudi medical journal1 mentions
- 2026Premature atherosclerotic cardiovascular disease in the MENA region: economic impact, barriers to care, and policy recommendations for an escalating crisis.Current opinion in lipidology1 mentions
- 2026Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans.American journal of human genetics1 mentions
- 2025Enhancing heart disease classification based on greylag goose optimization algorithm and long short-term memory.Scientific reports1 mentions
- 2025The impact of new-onset atrial fibrillation in the setting of acute coronary syndrome.Journal of cardiology1 mentions
- 2025Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry.European heart journal1 mentions
- 2025Trajectory of Cardiogenic Dementia: A New Perspective.Journal of cellular and molecular medicine1 mentions
- 2025USG-guided bilateral sphenopalatine ganglion block: A useful anesthetic adjuvant for trans nasal trans sphenoidal pituitary surgery in a patient with severely low ejection fraction.Saudi journal of anaesthesia1 mentions
- 2025Plasma Atrial Natriuretic Peptide Predicts Oxidized Low-Density Lipoprotein Levels in Type 2 Diabetes Mellitus Patients Independent of Circulating Adipokine and Cytokine.International journal of molecular sciences1 mentions
- 2025AI-Quantitative CT Coronary Plaque Features Associate With a Higher Relative Risk in Women: CONFIRM2 Registry.Circulation. Cardiovascular imaging1 mentions
- 2025The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma.Lancet (London, England)1 mentions
- 2025The Effect of Lithium Treatment on the Cardiovascular System.Cardiology in review1 mentions
- 2025The prevalence of metabolic syndrome in patients with non-alcoholic fatty liver disease in primary care clinics at King Saud University Medical City, Riyadh, Saudi Arabia.Frontiers in endocrinology1 mentions
- 2025Cardiac Magnetic Resonance Imaging and Coronary Computed Tomography Angiography in Cardiomyopathy: Diagnostic and Prognostic Insights.Echocardiography (Mount Kisco, N.Y.)1 mentions
- 2025Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function.European journal of heart failure1 mentions
- 2025Congenitally corrected transposition of the great arteries and coronary artery disease: a case report in an 83-year-old male.European heart journal. Case reports1 mentions
- 2025Genetic Factors Associated With Myocardial Infarction in Saudi Arabia.Journal of the Saudi Heart Association1 mentions
- 2025Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study.Discovery medicine1 mentions
- 2025Assessment of Primary Health Care Physicians' Awareness, Knowledge, and Practice of Familial Hypercholesterolemia in Jazan, Saudi Arabia.Cureus1 mentions
- 2025Association of Pathogenic/Likely Pathogenic Inherited Cardiomyopathy Variants With Heart Failure: A TOPMed Multiancestry Analysis.Mayo Clinic proceedings1 mentions
- 2025Circulating microRNAs as biomarkers for ischemic heart disease: a systematic review and gene set enrichment analysis.Frontiers in medicine1 mentions
- 2025Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023.Journal of the American College of Cardiology1 mentions
- 2025Prevalence of the QT interval prolongation and its risk factors in hospitalized geriatric patients: findings of a single center cross-sectional study in Pakistan.BMC geriatrics1 mentions
- 2025Whole-Exome Sequencing Reveals Rare Genetic Variants in Saudi COVID-19 Patients with Extreme Phenotypes.Viruses1 mentions
- 2025The association between inflammatory bowel disease and ischemic heart disease: A retrospective cohort study.Saudi medical journal1 mentions
- 2025Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.Lancet (London, England)1 mentions
- 2025Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.Lancet (London, England)1 mentions
- 2025Clinical Relevance of Right Atrial Strain Using Speckle-tracking Echocardiography: Emerging Insights and Future Prospective.Journal of cardiovascular echography1 mentions
- 2025Genetics of Cholesterol and Coronary Disease Risk across Six Global Ancestries.NEJM evidence1 mentions
- 2025Vascular Endothelial Growth Factor B Modulates Cardiac Functions via Ferroptosis Pathways in Post-Myocardial Infarction.Cells1 mentions
- 2025Determinants of place of death among individuals with cardiovascular disease: A Saudi sub-national register study.PloS one1 mentions
- 2025Role of P2X7 Receptor on Hypoxia-Induced Vascular Endothelial Growth Factor Gene Expression in H9c2 Rat Cardiomyocytes.Journal of cardiovascular development and disease1 mentions
- 2025A Message to Health Care Providers: "A" Blood Group Is Associated with Higher Heart Disease Risk in Young Saudi Men.Healthcare (Basel, Switzerland)1 mentions
- 2024Rationale and design of the CONFIRM2 (Quantitative COroNary CT Angiography Evaluation For Evaluation of Clinical Outcomes: An InteRnational, Multicenter Registry) study.Journal of cardiovascular computed tomography1 mentions
- 2024Aromatic Hydrocarbon Receptor Repressor (AHRR) is a biomarker of ambient air pollution exposure and Coronary Artery Disease (CAD).Environmental toxicology and pharmacology1 mentions
- 2024Successful Conservative Therapy for Infected Penile Implants: A Case Series.The American journal of case reports1 mentions
- 2024The Characteristics and Outcomes of Nonhospitalized Patients With Heart Failure in Saudi Arabia: A Contemporary Single-Center Study.Cureus1 mentions
- 2024Temporal Trend in Revascularization for Patients With Ischemic Cardiomyopathy and Multivessel Coronary Artery Disease.Journal of the American Heart Association1 mentions
- 2024Mortality and disability-adjusted life years in North Africa and Middle East attributed to kidney dysfunction: a systematic analysis for the Global Burden of Disease Study 2019.Clinical kidney journal1 mentions
- 2024Novel anti-psoriasis agent-associated cardiotoxicity, analysis of the FDA adverse event reporting system (FAERS).International journal of cardiology1 mentions
- 2024Pacemaker-induced Cardiomyopathy in Patients with Coronary Artery Disease: A Report of Three Cases.The Journal of innovations in cardiac rhythm management1 mentions
- 2024Cardiac Fibrosis Automated Diagnosis Based on FibrosisNet Network Using CMR Ischemic Cardiomyopathy.Diagnostics (Basel, Switzerland)1 mentions
- 2024Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.Nature1 mentions
- 2024Association of a single-nucleotide polymorphism in C12orf43 region with the risk of coronary artery disease.Cellular and molecular biology (Noisy-le-Grand, France)1 mentions
- 2024Quantification of myocardial scar of different etiology using dark- and bright-blood late gadolinium enhancement cardiovascular magnetic resonance.Scientific reports1 mentions
- 2024Cardiovascular Disease and Inpatient Complications in Turner Syndrome: A Propensity Score Analysis.Texas Heart Institute journal1 mentions
- 2024Identifying risk factors and mortality rate of premature coronary artery disease in young Saudi population.Scientific reports1 mentions
- 2024Risk factors for mortality in post-myocardial infarction patients: insights from the improve SCA bridge study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology1 mentions
- 2024Apolipoprotein E Gene Variation in Pakistani Subjects with Type 2 Diabetes with and without Cardiovascular Complications.Medicina (Kaunas, Lithuania)1 mentions
- 2024Impact of preoperative intra-aortic balloon pump on outcomes in coronary artery bypass grafting for unprotected left-main coronary artery disease.Cardiovascular diagnosis and therapy1 mentions
- 2024Characteristics of Stroke-related Seizures and their Predictive Factors: A Tertiary Care Center Experience.Annals of African medicine1 mentions
- 2024Incidence Rate of Cardiovascular Events in Rheumatoid Arthritis: An Observational Cohort Study in Saudi Arabia.Journal of multidisciplinary healthcare1 mentions
- 2024Exploring the Genetic Roles of Diet and Other Modifiable Risk Factors in the Risk of Angina: A Causal Investigation Using Mendelian Randomization in UK Biobank and FinnGen Cohorts.Life (Basel, Switzerland)1 mentions
- 2024Mathematical modeling for prediction of physicochemical characteristics of cardiovascular drugs via modified reverse degree topological indices.The European physical journal. E, Soft matter1 mentions
- 2024Abdominal Obesity-Metabolic Syndrome 3 Misclassified as Type 1 Diabetes Mellitus.JCEM case reports1 mentions
- 2024Impact of rs599839 Polymorphism on Coronary Artery Disease Risk in Saudi Diabetic Patients.Disease markers1 mentions
- 2024Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.The Lancet. Neurology1 mentions
- 2024Comparing the Effectiveness of Open and Minimally Invasive Approaches in Coronary Artery Bypass Grafting: A Systematic Review.Clinics and practice1 mentions
- 2024Rare variant contribution to the heritability of coronary artery disease.Nature communications1 mentions
- 2024Transforming Heart Failure Management: The Power of Strain Imaging, 3D Imaging, and Vortex Analysis in Echocardiography.Journal of clinical medicine1 mentions
- 2024Mechanistic insights and therapeutic potential of astilbin and apigenin in diabetic cardiomyopathy.Heliyon1 mentions
- 2024Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.Discovery medicine1 mentions
- 2024ANRIL's Epigenetic Regulation and Its Implications for Cardiovascular Disorders.Journal of biochemical and molecular toxicology1 mentions
- 2024The burden of diseases, injuries, and risk factors by state in the USA, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.Lancet (London, England)1 mentions
- 2024A Saudi Heart Association Position Statement on Cardiovascular Diseases and Diabetes Mellitus.Journal of the Saudi Heart Association1 mentions
- 2024Prognostic Value of Normal Triglyceride Levels among Patients with Target Low-density Lipoproteins Presenting with First Acute Coronary Syndrome.Heart views : the official journal of the Gulf Heart Association1 mentions
- 2023Independent Risk Factors for Thromboembolic Events in High-Risk Patients With Takotsubo Cardiomyopathy.Current problems in cardiology1 mentions
- 2023Risk of Adverse Cardiovascular Outcomes in Differentiated Thyroid Cancer Survivors: A Systematic Review and Meta-Analysis.Thyroid : official journal of the American Thyroid Association1 mentions
- 2023Stent as a Novel Technology for Coronary Artery Disease and Their Clinical Manifestation.Current problems in cardiology1 mentions
- 2023l-carnitine: Nutrition, pathology, and health benefits.Saudi journal of biological sciences1 mentions
- 2023Paraoxonase gene polymorphisms: Understanding the biochemical and genetic basis of coronary artery disease.Journal of Taibah University Medical Sciences1 mentions
- 2023Various Expressions of PIK3C2A and TXNIP Genes and Their Potential Role as Independent Risk Factors for Chronic Stable Angina and Acute Coronary Syndrome.Biomolecules1 mentions
- 2023Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.medRxiv : the preprint server for health sciences1 mentions
- 2023The impact of viability assessment using cardiac MRI and echocardiogram on the outcome of revascularization in patients with multi-vessels coronary artery disease and moderate to severe ischemic cardiomyopathy.Saudi medical journal1 mentions
- 2023Prevalence, hematological parameters, and coagulation profiles: Cardiovascular diseases statistics in the Asir region, Saudi Arabia.Saudi medical journal1 mentions
- 2023Advances and Challenges for GWAS Analysis in Cardiac Diseases: A Focus on Coronary Artery Disease (CAD).Current problems in cardiology1 mentions
- 2023Association of Statin Use With Risk of Liver Disease, Hepatocellular Carcinoma, and Liver-Related Mortality.JAMA network open1 mentions
- 2023Follow-up of CRT-D patients downgraded to CRT-P at the time of generator exchange.Frontiers in cardiovascular medicine1 mentions
- 2023Cardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysis.European journal of preventive cardiology1 mentions
- 2023Novel LDLR Variant in Familial Hypercholesterolemia: NGS-Based Identification, In Silico Characterization, and Pharmacogenetic Insights.Life (Basel, Switzerland)1 mentions
- 2023Role of single nucleotide polymorphism rs2383206 on coronary artery disease risk among Saudi Population: a case-control study.European review for medical and pharmacological sciences1 mentions
- 2023Advanced glycation end product signaling and metabolic complications: Dietary approach.World journal of diabetes1 mentions
- 2023Takotsubo cardiomyopathy following head and neck surgery: Can the fear of disfigurement be blamed?Saudi journal of anaesthesia1 mentions