CASP3
HGNC:1504 · 31 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CASP3 | “Pro-apoptotic signaling (BAX, CASP3 upregulation; BCL2 downregulation) and mitochondrial dysfunction further compromise mammary epithelial viability.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Hub genes such as TNF, IL6, CASP3, and GPX1 highlighted potential interactions among pathways affected by niclosamide.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Oxidative stress indicators (serum malondialdehyde [MDA] and reduced glutathione [GSH]) and pro-inflammatory cytokine transcription (CASP3, interleukin-6 (IL-6), tumor necrosis factor α (TNF-α)) were evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Protein expression validation was performed using immunofluorescence microscopy and qRT-PCR analysis targeting key apoptotic genes (p53, BAX, BCL-2, CASP3, Cyclin D1).” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Gene expression analysis using qRT-PCR examined key apoptosis-related markers (TP53, BAX, BCL2, CASP3).” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “In NT2/D1 cells, TG7 silencing using 20 nM DsiRNA3 led to a dose-dependent reduction in cell viability, with up to 48% inhibition observed at 200 nM (MTT assay, ****p < 0.0001). qRT-PCR analysis revealed significant upregulation of IL6 (3.2-fold), TNFα (2.8-fold), and CASP3 (2.5-fold) mRNA levels following TG7 knockdown (p < 0.0001), while p53 expression remained unchanged.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “RESULTS: Network pharmacology recognized 87 overlapping targets of Rhamnolipid and Surfactin with Alzheimer's disease, with hub genes involving CASP3, SRC, CTNNB1, HSP90AA1 and STAT3.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Protein-protein interaction (PPI) analysis highlighted ten key genes-EGFR, ESR1, HIF1A, HSP90AA1, MAPK1, BCL2, STAT3, TP53, CASP3, and SRC-implicated in the progression of various cancers, including breast, colorectal, liver, and lung tumors.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Subsequently, protein-protein interaction (PPI) network analysis identified top hub genes including AKT1, CASP3, TNF, and BCL2 as central to disease modulation.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Network pharmacology yielded 30 of such common targets of AD-neolupenol (e.g., GSK3B, CASP3, TNF, and BACE1), enriched in pathways such as amyloid processing, tau phosphorylation, oxidative stress response, and lipid metabolism (FDR-adjusted p < 0.0001).” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Platelet-Rich Plasma (PRP) Mitigates Silver Nanoparticle (AgNP)-Induced Pulmonary Fibrosis via iNOS/CD68/CASP3/TWIST1 Regulation: An Experimental Study and Bioinformatics Analysis.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Network pharmacology identified ESR1, CASP3, PPARG, and PTGS2 as key targets, with MQLEO components engaging apoptosis, inflammation (TNF, IL-17), and estrogen pathways.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Results demonstrated significant elevations in hepatic enzyme levels (ALT, AST), oxidative stress markers (MDA), inflammatory mediators (MAPK, NF-κB1, NLRP3, IL-1β, IL-6), and apoptotic factors (CASP3, BAX, P53), alongside reductions in antioxidant enzymes (GSH, GPx) in the ACR group.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Furthermore, hub genes such as IRS1, PIK3CA, CASP3, MAPK7, and PDGFRB were identified, supporting their central role in metabolic dysregulation during pregnancy.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Based on the STRING and Cytoscape network-analysis platforms, the top ten anti-AD core targets include APP, CASP3, IL6, BACE1, IL1B, ACE, PSEN1, GAPDH, GSK3B and ACHE.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “The most frequently interacting genes were HMOX1, CAT, NFE2L2, CASP3, MAPK1, CXCL8, PARP1, TNF, and PYGM.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Significant enhanced mRNA expression revealed enhanced induced CASP3, p53, and Beclin-1 mediated pro-apoptosis and induced NF-κB mediated autophagy in Hep-2 cells.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “AFB1 downregulated the expression of immune-inflammatory genes such Nrf2, IL-10, and BCL-2 genes, while up-regulating the caspase-3 (CASP3) gene (P < 0.05).” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Furthermore, network pharmacology analysis identified the top 10 hub genes, namely AKT1 (protein kinase B), CTNNB1 (catenin beta-1), SRC (proto-oncogene c-Src), TNF (tumor necrosis factor), EGFR (epidermal growth factor receptor), HSP90AA1 (heat shock protein 90α), MAPK3 (mitogen-activated protein kinase 3), STAT3 (signal transducer and activator of transcription 3), CASP3 (caspase protein), and ESR1 (estrogen receptor 1), which are responsible for hepatoprotective activity.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “The impact of fisetin on the mRNA and protein expression levels of apoptosis regulatory genes such as BIRC2/c-IAP1, CFLAR/cFLIP, CASP3, CASP7, CASPP9, TNFRSF10A/DR4, TNFRSF10B/DR5, and BID were examined by PCR array, qRT-PCR, and flow cytometry.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “In this in silico study, berberine chloride greatly modulated several potent CVDs-related targets, including SIGMAR1, GRP78, CASP3, BECN1, PIK3C3, SQSTM1/p62, LC3B, GLUT3, INSR, LDLR, LXRα, PPARγ, IL1β, IFNγ, iNOS, COX-2, MCP-1, IL10, GPx1, and SOD3.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Stimulation of apoptosis was achieved by upregulating the expression of BAX and CASP3 genes and downregulating the expression levels of BCL-2 gene.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “All the flavonoids were predicted to be orally bioavailable, with more than 90% targets as enzymes, including kinases and lyases, and with common targets such as NOS2, CASP3, CASP9, CAT, BCL2, TNF, and HMOX1.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Also, rutin significantly decreased the accumulation of β-galactosidase and reduced the expression of p53, p21, Bcl-2-associated X protein (Bax), caspase-3 (CASP3), and mammalian target of rapamycin (mTOR) in brain and hepatic tissues.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “In summary, we proposed that quercetin, luteolin, apigenin, catechin, epicatechin, stigmasterol, beta-sitosterol, celastrol, and betulic acid inhibit tumor growth by affecting tumor protein 53 (TP53), interleukin 6 (IL6), RAC-alpha serine/threonine protein kinases 1 (AKT1), caspase-3 (CASP3), tumor necrosis factor (TNF), jun proto-oncogene (JUN), heat shot protein 90 AA1 (HSP90AA1), vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor (EGFR), and SRC proto-oncogene (SRC).” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “PCT-ZN NSs pro-apoptotic activity was confirmed by the observed significant increased mRNA expression of CASP3, p53, and Bax as well as decreased expression of Bcl2.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Oleanolic acid interacted with the proteins AKR1B10, CASP3, CASP8, CYP1A2, CYP1A2, HMGB1, NAMPT, NFE2L2, NQO1, PPARA, PTGIR, TOP1, TOP2A, UGT2B10, and UGT2B11 and stigmasterol with ABCA1, ABCG5, ABCG8, CTSE, HMGCR, IL10, CXCL8, NR1H2, NR1H3, SLCO1B1, SREBF2, and TNF.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Of the top 15 proteins found by Cytoscape 3.6.1, 8, CAT and OGG1 (downregulated) and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 (upregulated), were dysregulated in diabetes-related kidney disease.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Notably, all tested SiO2NP concentrations significantly upregulated the transcription of CASP3 gene in gills and liver of Nile tilapia as compared to the control group.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “The ingredients (quercetin, formononetin, kaempferol, etc.,) from core herbs could modulate targets (PTGS2 (COX2), PTGS1 (COX1), IL6, CASP3, NOS2, and TNF, etc.), and thereby prevent the pharmacological and non-pharmacological renal injury comparable to that from COVID-19 infection.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Involvement of CASP3 promoter polymorphism (-1337 C > G) in the development and progression of non-small cell lung cancer.” | 0.98 | hgnc_dict_v1 |