C677T
C677T · SaudiVarKB evidence summary derived from retained literature mentions.
23Variant mentions
23Publications
8Associated gene records
16Associated phenotype records
Associated gene records
Co-mentioned in the same publicationsAssociated phenotype records
Co-mentioned in the same publications| Phenotype | Identifier / context | Articles | Mentions |
|---|---|---|---|
| diabetes mellitus | — | 5 | 5 |
| myocardial infarction | — | 4 | 4 |
| hypertension | — | 3 | 3 |
| stroke | — | 3 | 3 |
| obesity | HP:0001513 | 2 | 2 |
| coronary artery disease | — | 2 | 2 |
| leukemia | — | 1 | 1 |
| epilepsy | HP:0001250 | 1 | 1 |
| autism spectrum disorder | HP:0000729 | 1 | 1 |
| lymphoma | — | 1 | 1 |
| sickle cell disease | HP:0001878 · 603903 | 1 | 1 |
| renal failure | — | 1 | 1 |
| infertility | — | 1 | 1 |
| colorectal cancer | — | 1 | 1 |
| breast cancer | — | 1 | 1 |
| recurrent pregnancy loss | — | 1 | 1 |
Associated population records
Co-mentioned in the same publications| Population | Identifier / context | Articles | Mentions |
|---|---|---|---|
| Population record | Cohort 2 | 1 | 1 |
| Population record | Cohort 50 | 1 | 1 |
| Saudi Arabia · Jeddah | Cohort 87 | 1 | 1 |
| Population record | Cohort 200 | 1 | 1 |
| Population record | Cohort 62 | 1 | 1 |
| Saudi Arabia | Cohort 160 | 1 | 1 |
| Saudi Arabia · Eastern Province | — | 1 | 1 |
| Population record | Cohort 118 | 1 | 1 |
| Population record | Cohort 129 | 1 | 1 |
| Saudi Arabia | Cohort 105 | 1 | 1 |
| Population record | Cohort 413 | 1 | 1 |
| Population record | Cohort 106 | 1 | 1 |
| Population record | Cohort 138 | 1 | 1 |
| Population record | Cohort 96 | 1 | 1 |
| Population record | Cohort 300 | 1 | 1 |
| Population record | Cohort 66 | 1 | 1 |
| Saudi Arabia | Cohort 171 | 1 | 1 |
| Saudi Arabia · Qassim | Cohort 123 | 1 | 1 |
Supporting publications
23 records- 2025Colorimetric loop-mediated isothermal amplification (cLAMP) assay for the genotyping of a thrombophilia genetic risk factor, MTHFR (C677T).Analytical methods : advancing methods and applications1 mentions
- 2024Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with major depressive disorder in the Saudi patients attending Erada complex for mental health and Erada services - Jeddah, Saudi Arabia.Die Pharmazie1 mentions
- 2023Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor.Metabolites1 mentions
- 2023The Association Between MTHFR C677T Gene Polymorphism and Repeated Pregnancy Loss in Arabic Countries: a Systematic Review and Meta-Analysis.Reproductive sciences (Thousand Oaks, Calif.)1 mentions
- 2023Genetic Variants in the Mitochondrial Thymidylate Biosynthesis Pathway Increase Colorectal Cancer Risk.Current oncology (Toronto, Ont.)1 mentions
- 2023Detection of Methylene Tetrahydrofolate Reductase (MTHFR C677T) Mutation among Acute Lymphoblastic Leukemia in Sudanese Patients.Reports of biochemistry & molecular biology1 mentions
- 2022Role of metabolizing MTHFR gene polymorphism (rs1801133) and its mRNA expression among Type 2 Diabetes.Journal of diabetes and metabolic disorders1 mentions
- 2021MTHFR C677T Polymorphism and Serum Homocysteine Level as Risk Factors of Coronary Heart Disease in Patients with Androgenetic Alopecia: A Case Control Study.The American journal of the medical sciences1 mentions
- 2017Application of adaptive neuro-fuzzy inference systems (ANFIS) to delineate estradiol, glutathione and homocysteine interactions.Clinical nutrition ESPEN1 mentions
- 2016Population-level diversity in the association of genetic polymorphisms of one-carbon metabolism with breast cancer risk.Journal of community genetics1 mentions
- 2016Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders.Psychiatric genetics1 mentions
- 2016Associations of recurrent miscarriages with chromosomal abnormalities, thrombophilia allelic polymorphisms and/or consanguinity in Saudi Arabia.BMC medical genetics1 mentions
- 2015Evaluation of Gestational Diabetes Mellitus Risk in South Indian Women Based on MTHFR (C677T) and FVL (G1691A) Mutations.Frontiers in pediatrics1 mentions
- 2015Impact of MTHFR (C677T) gene polymorphism on antiepileptic drug monotherapy in North Indian epileptic population.Annals of Saudi medicine1 mentions
- 2013Combination of factor V Leiden and MTHFR mutations in myocardial infarction.Annals of Saudi medicine1 mentions
- 2012Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.International journal of health sciences1 mentions
- 2011Cerebral venous thrombosis associated with homozygous factor V Leiden mutation in a 15-year-old girl of Tunisian origin.Annals of Saudi medicine1 mentions
- 2009Case-control Study of methylenetetrahydrofolate reductase mutations and hyperhomocysteinemia and risk of stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association1 mentions
- 2008Thrombophilia in young patients with acute myocardial infarction.Saudi medical journal1 mentions
- 2008Polymorphism in methylenetetrahydrofolate reductase, plasminogen activator inhibitor-1, and apolipoprotein E in hemodialysis patients.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia1 mentions
- 2007Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East.Annals of hematology1 mentions
- 2004Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia.American journal of hematology1 mentions
- 2004Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease.Journal of thrombosis and thrombolysis1 mentions