TLR2
HGNC:11848 · 62 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “Molecular docking analysis demonstrated a favorable binding affinity for Toll-like receptor 2 (TLR2), while molecular dynamics simulations confirmed the structural stability of the complex.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Subsequently, the VC2 were docked to the toll-like receptors (TLR2, TLR3, and TLR4) and showed high binding affinities of -14.2 to -23.1kcal/mol, along with H-bonds (9 to 20).” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Protein-protein docking computationally predicted favorable binding interactions between the vaccine construct and human TLR2 and TLR4 receptors, with ClusPro docking scores of -1489.2 and -1198.1, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Docking studies revealed the stable binding of the vaccine construct to TLR1, TLR2, and TLR5, supported by favorable binding free energy values, indicating a robust immunogenic potential.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Across 500 ns molecular dynamics simulations, the vaccine construct remained conformationally stable and showed favorable predicted interactions with innate immune receptors, with strong binding free energies for TLR9 (ΔG = - 148.8 kcal/mol) and TLR2 (ΔG = - 16.7 kcal/mol).” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “A Mangifera indica L. extract functions as a broad TLR2/4/6 signalling rheostat to attenuate MyD88/NF-κB-driven inflammation and macrophage polarization.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Physicochemical and docking analysis identified constructs V1 and V5 as having strong binding affinities to Toll-like receptors TLR4 and TLR2, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Docking evaluation of hMPVbeta1 with TLR2, MHC class I, and MHC class II exhibited robust polar and non-polar interactions, signifying strong binding stability.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Association of TLR2 (rs5743708) Gene Polymorphism with Asthma Susceptibility and the Impact of Smoking: (Case-Control Study).” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Targeting FOXO3a, TLR2/MyD88/NF-κB cascade, and ferroptosis by theaflavin ameliorates iron-elicited liver toxicity.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Molecular docking and molecular dynamics (MD) simulations evaluated the interactions of V1 with human toll-like receptors (TLR2 and TLR3).” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “The docking investigation demonstrated the strong activity of the vaccine towards the TLR2 and TLR3, having binding affinity − 10.8 kcal/mol-1 and − 15.8 kcal/mol-1, and also disclosed remarkable constancy based on the 500ns simulation period.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “The constructed vaccine's physiochemical and structural features (secondary and tertiary), with structural stability (confirmed by molecular docking followed by dynamic simulation with TLRs (TLR4 & TLR2) and MHCs), were determined.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Gene expression analysis revealed that TLR2, CLEC4E, PTX3, CXCL8, and IL15RA were significantly upregulated (p < 0.05) in pneumonic ewes, while SOCS3 expression was markedly downregulated.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Various parameters were used to validate the designed MEVC which involved prediction of physiochemical properties, modeling and validation of the 3D structure, interaction with the immune receptors such as TLR2 (Toll-like receptor) and TLR4.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Recent findings suggest that the NP acts as a pathogen-associated molecular pattern (PAMP) that binds to Toll-like receptor 2 (TLR2), activating NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and MAPK (mitogen-activated protein kinase) signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “We aimed to assess the serum levels of wingless integration site family member 5 A (Wnt5a), leptin, and tumor necrosis factor-alpha (TNF-α) as markers of obesity-associated metaflammation and investigate the association with toll-like receptors2 (TLR2) gene (Arg753Gln) single nucleotide polymorphism (SNP) among Egyptian females.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “This effect was mediated through the downregulation of pro-inflammatory and stress-related genes, including IL-6, COX-2, iNOS, TLR2, TLR4, NLRP3, CHOP, JNK, XBP1, and ATF6.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, and TLR9 were significantly downregulated in both genotypes as compared to controls, with genotype D showing greater downregulation of TLR1, TLR5, TLR6, and TLR7 among HBV-positive patients.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Docking was conducted to check the binding energy of the designed peptide vaccine with the human immune receptors, namely TLR2 and TLR4.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Remarkably, QRT supplementation elicited dose-dependent upregulation (P < 0.001) of key immune-related genes, such as intеrlеukin-4 (IL-4), interferon-γ (INF-γ), Toll-like receptor 2 (TLR2), and tumor necrosis factor-α (TNF-α) in the splenic tissue.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “The mRNA abundance of the proinflammatory genes tumor necrosis factor, toll-like receptor 2 (TLR2), and TLR4 in the ruminal epithelium peaked (P < 0.05) at FRP and remained higher at POST.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Protein-protein docking and MD simulation found that vaccines 3 was more stable and had a higher binding affinity for TLR2 and TLR4 immune receptors.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Toll-like receptor 2 (TLR2) play an essential role in innate immunity.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Moreover, the molecular interaction of MEVC with TLR2, molecular simulation, and binding free energy analyses further validated the immune potential of the construct.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Molecular docking results validated the robust interaction of MEVC with immune receptors such as TLR2/4.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Moreover, qPCR and western blot results indicated that TLR2, TLR4, proinflammatory mediators, and apoptosis-mediated genes upregulated except Bcl-2, which is antiapoptotic, and there were downregulations of oxidative stress-related genes in the infected uterine tissue.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “The vaccine's binding stability with Toll-like receptor 2 (TLR2) and TLR4 was confirmed using molecular docking and molecular dynamics (MD) simulation.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Zerumbone reduces TLR2 stimulation-induced M1 macrophage polarization pattern via upregulation of Nrf-2 expression in murine macrophages.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “In addition, dietary 2.0-mL SEO/kg diet significantly upregulated antioxidant genes expression (CAT, SOD, GPx, GST, and GSR) with downregulation of apoptotic genes (HSP70, TLR2, caspase-3, and PCNA) in the liver.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Furthermore, strong interactions were demonstrated with toll-like receptors 2 (TLR2) and 4 (TLR4) according to the molecular dynamic simulation studies.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “In silico docking and simulation studies suggested a stable interaction between the multi-epitope candidate vaccine and human toll-like receptor 2 (TLR2).” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Molecular docking, binding free energy calculation, and in silico cloning revealed robust interaction of the designed MVC with toll-like receptor 2 (TLR2) and efficient expression in E.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “DNA sequencing of PRLR (304-bp), LTF (904-bp), TLR2 (420-bp), TLR4 (335-bp), CLA-DRB3.2 (285-bp), SOD3 (735-bp), CAT (1526-bp), GPX4 (782-bp), and GST (690-bp) revealed SNPs associated with reproductive disorders tolerance/susceptibility in investigated does.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “In parallel, heat-inactivated PD-associated total bacteria and Klebsiella variicola increased the expression of TNFα, IL-1β, IL-6, TLR2, and TLR9 in microglial cells (1.6-, 83-, 3.2-, 1.5-, 1.5-fold, respectively p < 0.01).” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “The present study aimed to use a whole milk stimulation assay for investigating the modulatory effect of selected Toll-like receptor (TLR) ligands on the phenotype and function of milk immune cells. (2) Methods-camel milk samples (n = 7) were stimulated in vitro with the TLR4 ligand LPS or the TLR2/1 ligand Pam3CSK4, and separated milk cells were evaluated for stimulation-induced shape change, the expression of cell surface markers, phagocytosis, apoptosis, ROS production, and NETosis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Leishmania LPG can utilizes TLR2 to evade host-immune responses.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “The aim of the present study was to investigate the role of the toll-Like receptors (TLR2 and TLR4) signaling pathway and its downstream effector chemokine genes in the pathogenesis of chronic dacryocystitis.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Investigation of TLR2 and TLR4 Polymorphisms and Sepsis Susceptibility: Computational and Experimental Approaches.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Whereas, other gene mutations in ABCB1, ABCC1, CASR, IL-17F, NOTCH1, NOTCH4, PRNCR1, TDG, TLR2, TLR4, TLR-9, TSLP, TSLPR and TNF-α genes showed irrelevant correlation with CRC risk in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “SRA1 expression associated with TLR2, IRAK1, and IRF3 expression only in individuals with obesity, regardless of diabetes status.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “AIM: This work aims to compare the changes in kidney and heart function bioindicators and expressions of TLRs (TLR2 and TLR2) as well as ACE2 and NRP-l receptors in moderate and severe COVID-19 patients.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “The Protective Effect of Anethole against Renal Ischemia/Reperfusion: The Role of the TLR2,4/MYD88/NFκB Pathway.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Molecular docking and molecular dynamics simulation indicated a stable and energetically favourable interaction between the constructed antigen and Toll-like receptors (TLR2, TLR3, and TLR4).” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Molecular interactions with major histocompatibility complex-1 (MHC-I), Toll-like receptors-2 (TLR2), and glucose-regulated protein 78 (GRP78), with scores of -896.0, -948.4, and -925.0, respectively, demonstrated its potential to bind with the human immune receptors.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “In this study, we compared the relative gene expression levels of the Akt1s1, FGF, GH, IGF1, MSTN, TLR2, TLR4 and TLR5 genes in blood in groups of common carps (Cyprinus carpio), which belonged to different growth types and phenotypes.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Synonymous and non-synonymous polymorphisms in toll-like receptor 2 (TLR2) gene among complicated measles cases at a tertiary care hospital, Peshawar, Pakistan.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Twelve SNPs were investigated as follows: rs16944 (IL-1B), rs1143634 (IL-1B), rs1800587 (IL-1A), rs2069762 (IL-2), rs3212227 (IL-12B), rs2234650 (IL-1R1), rs315952 (IL-1RN), rs3804099 (TLR2), rs4986790 (TLR4), rs4986791 (TLR4), rs1800629 (TNF) and rs361525 (TNF).” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “The impact of Prg4 recombination on synovial macrophage populations of 2- and 6-month-old animals and infiltration of pro-inflammatory macrophages in response to a TLR2 agonist challenge was determined.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “The objectives of this study were to investigate polymorphisms and changes in expression patterns of the genes FGF5, PGAM2, TLR2 and IL10 in V-line, Baladi Black and Baladi Red rabbits.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “MATERIALS AND METHODS: The association between the common single nucleotide polymorphisms (SNPs) in the genes of TLR2, 4, 9 and 10 and H. pylori-related gastric diseases were investigated by molecular methods after the confirmation of H. pylori infection.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Interestingly, we could not see any involvement of TLR2 or TLR3 nor suppression of infection by IFN-β production.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Continuous exposure to 108 CFU of bifidobacteria activated both macrophages and Treg immune cells through significantly increasing the expression of mucosal TLR2 and IL10-mRNA genes, but inhibited Th1 and Th2 cells via significant downregulation of IL4 and IFNγ gene expression, compared to untreated mice.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “We investigated the effect of resveratrol treatment on TLR2, TLR3, TLR4, NF-κB, and inducible nitric oxide synthase (iNOS or NOS2) levels in CD4 spleen cells.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Our aim was to investigate the expression and polymorphisms of TLR2 and their association with colon cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Toll-like receptor2 (TLR2) and Nod-like receptor protein 3 (NLRP3) Inflammasome are implicated in hepatic steatosis, inflammation and fibrosis; the histological landmark stages of NASH.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Treatment of BTBR mice with SCH increased the percentage of splenic CD14+TLR2+ cells, CD14+TLR3+ cells, CD14+TLR4+ cells, and decreased the percentage of CD14+IL-27+ cells, as compared to the untreated BTBR mice.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “OBJECTIVE: In this study, the genotype frequencies of TLR2 and TLR6 in smoking and nonsmoking population were examined.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “PATIENTS AND METHODS: Polymorphisms of the TLR2, 3, 4, and 9 genes were measured in 52 cases of EBVaGC and 157 cases of EBV-negative GC (EBVnGC).” | 0.98 | hgnc_dict_v1 |