TERT
HGNC:11730 · 43 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TERT | “The genes associated with tumor suppression (p53, BRCA1, and BRCA2), telomere length maintenance (TERT), DNA damage response (FGFR2), and DNA repair (CHD1) are recognized for their intricate function in tumor genesis and progression.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Circulating tumor DNA (ctDNA) enables the quantitative tracking of BRAF, NRAS, and TERT mutations using droplet digital PCR (ddPCR) and next-generation sequencing (NGS).” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “TERT mutation alone occurred in 16.9% of SDM vs.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “These included 3 ACD variants in 30 patients (NM_001082486.2: c.22G>A, c.617A>C and c.824C>T), 2 variants in TERF1 in 4 patients (NM_003218.4: c.162_163insGAG and c.1126C>G) and 3 variants in TERT in 5 patients (NM_198253: c.769G>T, c.76A>G and c.1323_1325del).” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “On multivariate analysis, TCV histology remained an independent predictor of recurrence (OR = 2.09; 95% CI, 1.28-3.40; p = 0.0031), along with age ≥ 55, extrathyroidal extension, nodal metastases, advanced T stage, and TERT promoter mutations.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Role of TERT gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review).” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “This study investigates eight key genes (BRAF, EIF1 AX, FOXE1, KRAS, PDGFRA, PIK3 CA, PTEN, and TERT) that are deregulated in Hashimoto's Thyroiditis and their roles in thyroid cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Additionally, the NCP treatment upregulated the expression of key genes of oxidative stress resistance, mitochondrial function, and reproductive health, including SIRT1, FOXO3a, and TERT.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “TERT promoter mutations in gliomas: Molecular roles in tumorigenesis, metastasis, diagnosis, prognosis, therapeutic targeting, and drug resistance.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Advances in molecular diagnostics have identified key genetic alterations - particularly BRAFV600E, RAS mutations, RET/PTC fusions, and TERT promoter mutations - that are strongly linked to tumor aggressiveness and prognosis.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “For instance, renal cell carcinoma frequently harbors alterations in VHL, PBRM1, and BAP1, influencing therapeutic responses, while urothelial carcinoma is characterized by FGFR3 mutations and TERT promoter alterations, which have implications for targeted therapy.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Clinical and Histopathological Features of Thyroid Cancer with TERT Promoter Molecular Alterations in Isolation Versus with Concurrent Molecular Alterations: A Multicenter Retrospective Study.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “On multivariate analysis, age (more than 45 years), presence of metastatic disease and tumors harboring telomerase reverse transcriptase (TERT) promoter mutations were independent prognostic factors for poor DTC-specific survival.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Identification of polymorphic alleles in TERC and TERT gene reprogramming the telomeres of newborn and legacy with parental health.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Real-time qPCR data showed that the level of telomere length- gene TERT significantly downregulated (10.43 ± 0.1) in the D-Gal-treated mice with respect to control (21.97 ± 0.5).” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “We also conducted BRAF and TERT mutations analyses through Sanger sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “How do BRAFV600E and TERT promoter mutations interact with the ATA and TNM staging systems in thyroid cancer?” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Other important genetic alterations in the more advanced types of TC include TERT promoter, TP53, EIF1AX, and epigenetic alterations.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “RESULTS: Three tumors were tested only by Sanger sequencing and were negative for BRAFV600E, HRAS, KRAS, NRAS, TERT promoter, PTEN, and PIK3CA mutations.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Effect of Having Concurrent Mutations on the Degree of Aggressiveness in Patients with Thyroid Cancer Positive for TERT Promoter Mutations.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “RESULTS: All patients were IDH wild-type and TERT wild-type, and P53 was overexpressed.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Upregulated Telomerase activity and reactivation of telomeres is observed in > 70 % of cancer patients by TERT point mutations, rearrangements, DNA amplifications, and transcript fusions, making it a useful marker in diagnosis and prognosis of various cancers.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “PTCH1 (14/31), TERT (12/31), and SMO (7/31) variants were common.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Papillary Thyroid Cancer and a TERT Promotor Mutation-positive Paraganglioma in a Patient With a Germline SDHB Mutation.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Various studies on genomic analyses of glioma found a variety of deregulated genes with somatic mutations including TERT, TP53, IDH1, ATRX, TTN, etc.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Risk Factors for TERT Promoter Mutations with Papillary Thyroid Carcinoma Patients: A Meta-Analysis and Systematic Review.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “TERT Promoter Mutations Are an Independent Predictor of Distant Metastasis in Middle Eastern Papillary Thyroid Microcarcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “There was a higher rate of recurrence (p < 0.0001) and TERT mutations (p = 0.0003) in male PTC patients than in female patients.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “RAI-refractory tumors were significantly associated with distinct aggressive clinicopathological features, including positive surgical margins (p = 0.016) and the presence of lymph node metastases at primary diagnosis (p = 0.012); higher nonsilent tumor mutation burden (p = 0.011); TERT promoter (TERTp) mutation (p < 0.0001); and the enrichment of the APOBEC-related single-base substitution (SBS) COSMIC mutational signatures 2 (p = 0.030) and 13 (p < 0.001).” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Sanger Sequencing and immunohistochemistry was employed to investigate the TERT promoter mutations and TERT protein expression with their association to clinicopathological characteristics in over 2200 samples of Middle Eastern origin from 13 different types of cancers.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “An additional analysis of these samples for the most frequently reported mutations in DTC such as BRAFV600E, TERT promoter, and RAS showed a prevalence of 38.87% (117/301), 11.96% (36/301), and 7.64% (23/301), respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Promoter mutation in the telomerase reverse transcriptase (TERT) gene is identified to be a prognostic marker in PTC.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Recently tested CNSTs biomarkers include VEGFR-2, EGFRvIII, IL2, PDGFR, MMPs, BRAF, STAT3, PTEN, TERT, AKT, NF2, and BCL2.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “This study comprehensively investigated a large series of pediatric DTC for single point mutations in BRAF, HRAS, KRAS, NRAS, PIK3CA, PTEN, and TERT.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “TERT Promoter Mutations in Thyroid Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Erratum to: TERT promoter hot spot mutations are frequent in Indian cervical and oral squamous cell carcinomas.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Uncommon TERT Promoter Mutations in Pediatric Thyroid Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “TERT promoter hot spot mutations are frequent in Indian cervical and oral squamous cell carcinomas.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40,245 controls, we found that the protective allele [G] at one previously-identified CRC polymorphism, rs2736100 near TERT, was associated with EC risk (odds ratio (OR) = 1.08, P = 0.000167); this polymorphism influences the risk of several other cancers.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “TERT promoter mutations in thyroid cancer: a report from a Middle Eastern population.” | 0.98 | hgnc_dict_v1 |
| gene | TERT | “Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs.” | 0.98 | hgnc_dict_v1 |