CXCR4
HGNC:2561 · 28 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCR4 | “WHIM syndrome in a child without the classic tetrad: a case confirmed by de novo CXCR4 mutation.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “In cancer, xanthohumol demonstrates remarkable efficacy by inhibiting tumor growth, angiogenesis, and metastasis through the suppression of critical pathways like CXCR4 and STAT3.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Discussion: Preclinical studies suggest that beta-blockers modulate molecular pathways implicated in AVM pathophysiology, including VEGF, HIF-1α, SDF1α/CXCR4, MMP-9, and Notch-associated signaling.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “RESULTS: Malignant cells showed the highest expression of MIF, which may interact with CD74 + CXCR4 + and CD74 + CD44 + receptor complexes on B cells, T cells, and myeloid cells, consistent with known MIF-mediated signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Specifically, we investigated the effect of SRN-18 on the mRNA and protein expression levels of CXCR4 and CXCR7, as well as its influence on the expression of MMP-2, MMP-9, and key EMT-associated proteins.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Analysis of the glycosaminoglycan analog dociparstat sodium reveals significant activity in myeloid malignancies, mediated by specific interference with CXCL12/CXCR4 signaling cascades.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “These include the entrance receptors CCR5 and CXCR4, as well as the proviral integration protein LEDGF/p75.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Secretory Trefoil Factor 1 (TFF1) promotes gemcitabine resistance through chemokine receptor CXCR4 in Pancreatic Ductal Adenocarcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “We evaluated the mRNA levels of CCR3, CCR7, CCR9, CXCR3, CXCR4, and CXCR6 chemokine receptors in the brain.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Human Wharton's jelly-derived mesenchymal stromal stem cells preconditioned with valproic acid promote cell migration and reduce renal inflammation in ischemia/reperfusion injury by activating the AKT/P13K and SDF1/CXCR4 pathways.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “CXC chemokine receptor 4 (CXCR4) blockade in cancer treatment.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Toll-Like Receptor Signaling in the Pathogenesis of Chronic Dacryocystitis: Implication of c-FOS Transcription Factor and its Downstream Effector Chemokine Genes CCL2, CCL4, CXCL3, CXCR4 with a Shift of the M1/M2 Macrophage Phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “In the present study, we evaluated the expression of JUNB and CXCR4 in circulating tumor cells (CTCs) of lung cancer patients and investigated whether these proteins have prognostic clinical relevance.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “We compared Ki-67 production in CD3+, CD4+, CD8+, CXCR4+, CXCR7+, CD45R+, HLA-DR+, GATA3+, Helios+, and FOXP3+ peripheral blood mononuclear cells (PBMCs) in autistic children to typically developing (TD) controls using immunofluorescence staining.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “In post-NAT residual tumors, RR cases showed high expression of SOX2 and CXCR4.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Furthermore, 5-AIQ treatment decreased CXCR4, IFN-γ, IL-22, STAT1, and RORγT mRNA expression levels in brain tissue.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “The chemokine receptor CXCR4 and its ligand CXCL12 regulate oculomotor nerve development; mice with loss of either molecule have oculomotor synkinesis.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “The objective of the present study was to further explore the role of S3I-201 in BTBR mice, and this was performed by investigating the effects of S3I-201 treatment on lymphocyte activation markers (CD4+CD25+ and CD4+CD69+), chemokine receptors (CD4+CCR6+, CD4+CCR7+, CD4+CXCR4+, and CD4+CXCR5+), and proinflammatory cytokines (CD4+IL-6+ and CD4+TNF-α+) in the spleen cells of BTBR and C57BL/6 (C57) mice.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “In this study, we examined the effects of A2A receptor antagonist SCH5826 (SCH) and A2A receptor agonist CGS21680 (CGS) on C-C and C-X-C chemokine receptors (CCR3, CCR4, CCR5, CCR6, CCR7, CXCR3, CXCR4, and CXCR5) on splenic CD8+ T cells in the BTBR autistic mouse model.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “MNCs cytometry showed higher percentage of CXCR4 double positivity for both CD34 and CD31 positive cells, indicating a functional improvement.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Flow cytometric analysis, using peripheral blood mononuclear cells (PBMCs), revealed the numbers of CD4+, CD8+, CD28+, CXCR4+, and CCR7+ expressing HLA-DR cells in typically developing (TD) controls and children with ASD.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “Systems analysis led to a strong correlation between Meth exposure and enhancement of molecules associated with chemokines and chemokine receptors, especially CXCR4 and CCR5, which function as co-receptors for viral entry.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “RESULTS: Diabetes and intravitreal injection of HMGB1 in normal rats induced significant upregulation of the mRNA levels of the chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) receptor CXCR4 and protein levels of hypoxia-inducible factor-1α, early growth response-1, tyrosine kinase 2 and the CXCL12/CXCR4 chemokine axis.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “RESULTS: Flow cytometric analysis of the surface expressions of CXCR4 (CXCL12 receptor) and CCR7 (CCL21 receptor) on B and T cells revealed that the surface expressions of CXCR4 and CCR7 were not significantly altered in diabetic and WP-supplemented diabetic mice compared with control mice.” | 0.98 | hgnc_dict_v1 |