PTEN
HGNC:9588 · 116 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PTEN | “The cross-talk between GSK-3β, RKIP, and PTEN as potential targets for therapeutic implications in cancer: a comprehensive insight.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Expression of cell cycle regulators (CCND1, CCND3, p21, and p27), apoptotic markers (BCL2, Bcl-2-associated X protein, cytochrome c, caspase-8, caspase-9, and caspase-3), and metabolic mediators (protein kinase B [Akt], mammalian target of rapamycin [mTOR], adenosine monophosphate-activated protein kinase [AMPK], and phosphatase and tensin homolog [PTEN]) was analyzed by quantitative reverse transcription-polymerase chain reaction.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Elacestrant improved progression-free survival in ESR1-mutated disease in the EMERALD trial, capivasertib plus fulvestrant demonstrated significant benefit in tumors harboring AKT/PIK3CA/PTEN pathway alterations in CAPItello-291, and inavolisib plus palbociclib and fulvestrant achieved both progression-free and overall survival improvement in PIK3CA-mutated patients with early relapse in INAVO120.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “BACKGROUND: The process of cancer progression is maintained through a feedback loop whereby reactive oxygen species (ROS) induce inflammatory cytokines, which activate STAT3 and result in miRNA-21 upregulation. miRNA-21 enhances the AKT signaling pathway and suppresses PTEN, promoting the proliferation of the cancerous cells and the additional production of ROS.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Dysregulation of this pathway, often through PTEN loss or upstream receptor activation, has been increasingly implicated in the pathogenesis of LMS, making it a critical therapeutic target.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Gene expression analysis by qRT-PCR and immunofluorescence showed altered expressions of genes linked to apoptotic (Caspase-3, 8, 9, and Bcl2, Bax, Bid, Cytochrome c, PTEN) and metastasis (MMP-9) protein.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Targeting DNMT1 restores PTEN expression in colorectal cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Validated targets concentrated on key leukemia-related genes like PTEN, BCL2L11, CDKN1A, CCND1, RB1, E2F1, and TGFBR2.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Luteolin, a dietary flavone, has emerged as a promising candidate due to its regulatory effects on redox balance, NF-κB/MAPK signaling, PI3K/AKT/PTEN pathways, TGF-β/Smad-mediated fibrosis, and estrogen and progesterone receptor activity.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “In prostate cancer this pathway is generally altered due to the mutation or deletion of the PTEN (phosphatase and tensin homolog) gene and unnecessary activities of some components of PI3K, AKT, or mTOR.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Major tumor suppressive pathways affected include Tp53-mediated apoptosis and genomic stability, RB-dependent cell cycle regulation, PTEN/PI3K/AKT survival signaling, Hippo pathway control of proliferation and stemness, and DNA damage response mechanisms.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “PFI identified IDH1 as the most critical predictor, while SHAP values revealed that, in addition to IDH1, features like Age, PTEN, ATRX, and CIC have considerable influence on model predictions.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The oncoproteins E6 and E7 from HPV can disrupt normal miRNA biogenesis, leading to the suppression of tumor-suppressor genes such as PTEN and PDCD4 and the activation of oncogenic signaling networks.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Galangin mitigates letrozole-induced polycystic ovary syndrome in rats by restoring PI3K/pAKT/PTEN signaling.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Bannayan-Riley-Ruvalcaba Syndrome (BRRS) is a rare genetic disorder caused by germline mutations in the phosphatase and tensin homolog (PTEN) gene, leading to overgrowth and classified under PTEN hamartoma tumor syndrome (PHTS).” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Notably, 38 patients were classified as rare monogenic SAIDs, linked to mutations in genes, including NLRC4, LPIN2, RIPK1, PLCG2, PIK3CD, ISG15, ZNFX1, STAT1, SOCS1, OTULIN, PTEN, GJB2, SLC29A3, and IL-17RA.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Then, protein-protein interaction (PPI) network analysis pinpointed seven top-ranked DEGs (GAPDH, PTEN, CCND1, APOE, ESR1, MAPK3/ERK1, and SNCA) as KGs or central modulators of PD pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Molecular docking provided comparative predictions of miR-155 interactions with regulatory proteins (IL-13RA1, SOCS1, PTEN, BCL-6, TP53INP1).” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “These variants exhibited a strong chromatin profile. hsa-miR-6074 was reported to regulate p53 signaling, melanoma, FoxO signaling, glioma, MAPK, IL-17, PD-L1, HIF1A, TRAF6, PTEN, carbon metabolism, autophagy, and cellular senescence related pathways.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “High-risk genes, including BRCA1, BRCA2, PALB2, TP53 and PTEN, with germline pathogenic or likely pathogenic variants (PVs/LPVs), substantially increase the risk of breast cancer and other malignancies.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Targeting WWPI HECT Domain by Small Inhibitors for Restoring PTEN Tumor Suppressive Role in Glioblastoma Therapy.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The oncogenesis includes activation of pro-inflammatory markers (IL-6, IL-1β, TNF-α), resulting in overexpression of oncogenes, downregulation of tumor suppressor genes (TSGs) like p53, pRb, APC, PTEN, suppression of antioxidant enzymes (GSH, CAT, SOD), and activation of signaling pathways (PI3K/Akt/mTOR/NF-κB, Ras/MAPK).” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Tumor suppressor genes (TSGs) like p53, PTEN, INK4, MADR2, APC, and oncogenes such as HER2, BCR/ABL1, CMYC, EML4AK, RAS, WNT, ERK, and TRK get mutated by OS.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Moreover, it can inhibit inflammatory markers (IL-6, TNF-α, and IL-1β), downregulate oncogenes (Ras, HER2, MYC, and BCR/ABL1), and upregulate tumor suppressor genes (TSGs) such as TP53, PTEN, and BRCA1 and BRCA2 expression.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Top scored complexes PD-L1/Ligands and PTEN/ligands were simulated using molecular dynamics.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Various molecular pathways involved in causing lung cancer such as PTEN/PI3K/AKT pathway, JAK/STAT pathways, RAF-MEK-ERK, PI3K-AKT-mTOR, and RALGDS-RA, PI3K, AKT, and PI3K/AKT/mTOR pathway.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “This study investigates eight key genes (BRAF, EIF1 AX, FOXE1, KRAS, PDGFRA, PIK3 CA, PTEN, and TERT) that are deregulated in Hashimoto's Thyroiditis and their roles in thyroid cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “This review highlights key molecular pathways involved in oncogenesis, focusing on genetic alterations (mutations, amplifications, and translocations) in oncogenes (RAS and MYC) and tumor suppressor genes (TP53 and PTEN).” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “This was evidenced by downregulation of PI3K, AKT, and mTOR genes alongside the upregulation of PTEN, a critical tumor suppressor.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The triple therapy also showed the strongest suppression of the PI3K/AKT/mTOR/HIF1α pathway, with a concurrent increase in its endogenous inhibitors (PTEN and AMPKα) in all cell lines used.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “These miRNAs influence key genes, including FOXO3, NFAT3, PTEN, RHOA, VEGFA, SMAD7, and CDK2, playing significant roles in both tumor suppression and oncogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Differential co-expression analyses revealed distinct gene and miRNA profiles for IDH1Wt and IDH1Mu glioblastomas, with specific upregulation of PTEN and downregulation of MUC16 in IDH1Wt, and upregulation of PIK3R1 in IDH1Mu.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Investigation of GSTP1 and PTEN gene polymorphisms and their association with susceptibility to colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Furthermore, the therapeutic implications of ncRNAs such as lncRNA UCA1 and miR-3960 in chemoresistance and progression are also discussed via suppression of EZH2 and PTEN/AKT pathways.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Somatic PTEN and ARID1A loss and endometriosis disease burden: a longitudinal study.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Targeting of PP2 A/GSK3β/PTEN Axis in Alzheimer Disease: The Mooting Evidence, Divine, and Devil.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Genetic testing using whole exome sequencing confirmed the diagnosis, identifying a pathogenic de novo phosphatase and tensin homolog gene (PTEN) variant (Chr10 NM_000314.8: c.17_18del p.(Lys6Argfs*4)) in a heterozygous state.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Here, we studied cases with a PTEN pathogenic variant identified between 2007 and 2020 in our laboratory (n = 58), and for whom brain imaging was available.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Furthermore, CNVs in the MYC and PTEN genes were observed in 15% and 10% of the patients, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Furthermore, unlike Sorafenib, treatment with Acivicin and Azaserine significantly affected apoptotic signaling in treated cells, indicating the role of both amino acid analogs in activating programmed cell death (PCD), as assessed by the Annexin-V assay, DAPI staining, and the relative expression of tumor suppressor genes PTEN and P53.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Our analysis revealed that hsa-miR-320a-3p and its key targets, including PTEN, AKT1, BCL2, FOXO1 and MYC, are dysregulated in T1D, along with their interacting partners namely BLIMP3, GSK3B, CAV1, CXCL3, TGFB, and IL10.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “These include hereditary diffuse GC, familial adenomatous polyposis, hereditary nonpolyposis colon cancer, Lynch syndrome, and three major hamartomatous polyposis syndromes associated with CRC and GC, namely Peutz-Jeghers syndrome, juvenile polyposis syndrome, and PTEN hamartoma syndrome.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Sanger sequencing was used to analyze peripheral blood DNA from these individuals to detect disease-causing mutations in the BRCA1, BRCA2, PTEN, TP53, and ATM genes.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “In addition, the qRT-PCR technique authenticates the A. fragrantissima -induced apoptotic network genes (Caspase-3, Caspase-8, Caspase-9, Cytochrome c, BCL-2, BID, BAX, PARP, PTEN, PI3K, and Akt) expression were evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Different studies have suggested that a few autophagy-oriented genes, such as PTEN, Rab11a, Atg12, SIPA1L2, and ATG5, are all targeted by miR-21, indicating its essential role in the regulation.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “We did not find any mutations in genes such as BRAF, IDH1, CDKN2A, PTEN, and TP53, which are also listed as cancer-driver genes in gliomas.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Seven genes (PTEN, H3, ARIH1, SDR16C5, PFN, glnA GLUL, and SRX1) were identified as the most significant (Log2 (FC) value 4) for molecular mode of action in vitro.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Prognostic role of immunohistochemical PTEN (phosphatase and tensin homolog) expression and PTEN (rs701848) genotypes among Egyptian patients with different stages of colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “PTEN, ERG, SPINK1, and TFF3 Status and Relationship in a Prostate Cancer Cohort from Jordanian Arab Population.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “PROGNOSTIC IMPLICATIONS OF PD-L1 EXPRESSION AND LOSS OF PTEN IN PATIENTS WITH RHABDOMYOSARCOMA, EWING'S SARCOMA AND OSTEOSARCOMA.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Mutational Landscape and In-Silico Analysis of TP53, PIK3CA, and PTEN in Patients with Breast Cancer from Khyber Pakhtunkhwa.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “As a result, higher gene and protein expression levels of PTEN, P27, and P57 were observed in patients with oligospermia.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “In addition, 99 cases (32.8%) were associated with CS, and 60 (19.9%) had a confirmed phosphatase and tensin homolog (PTEN) mutation.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Out of these genes, MCL1, IGF1R, CCND1, and PTEN were identified as hub genes and were found to have significant (p < 0.05) variations in their mRNA and protein expressions and effects on the overall survival (OS) of the KIRC patients.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Dysregulation of molecular pathways such as PTEN, PI3K/Akt, Nrf2 and others result in changes in CP response of GC cells.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “LncRNAs and PTEN/PI3K signaling: A symphony of regulation in cancer biology.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Out of a total of 25 PI3K pathway-related genes, we developed and validated a diagnostic and prognostic model based on the up-regulation of TP53 (tumor protein 53) and CCND1 (Cyclin D1) and the down-regulation of PTEN (Phosphatase and TENsin homolog deleted on chromosome 10), and GSK3B (Glycogen synthase kinase-3 beta) hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “After comprehensively analyzing these 233 ferroptosis driver genes by various TCGA databases, RNA-sequencing (RNA-seq), and Reverse Transcription Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR) techniques, TP53 (tumor protein 53), PTEN (Phosphatase and TENsin homolog deleted on chromosome 10), KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), and HRAS (Harvey Rat sarcoma virus) were identified as differentially expressed hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “RESULTS: We identified 355 DEGs and predicted BC-associated pathways, including kinetochore metaphase signaling, PTEN, senescence, and phagosome-formation pathways.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Of the 310 subjects, 119 (38.4%) were carriers of pathogenic or likely pathogenic variants (PVs) affecting one or more of the following genes: TP53, ATM, CHEK2, CDH1, CDKN2A, BRCA1, BRCA2, PALB2, BRIP1, RAD51D, APC, MLH1, MSH2, MSH6, PMS2, PTEN, NBN/NBS1 and MUTYH.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The best model of 7/52 genetic CNAs, which included the SPOP alteration, SPP1 alteration, CCND1 amplification, PTEN deletion, CDKN1B deletion, PARP8 deletion, and NKX3.1 deletion, stratified the PCa cases into a localised and advanced disease with an accuracy of 70.0%, sensitivity of 85.4%, specificity of 44.9%, positive predictive value of 71.67%, and negative predictive value of 65.35%.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Genetic alterations and the overexpression of several genes, such as FOXA1, AR, PTEN, RB1, TP53, etc., suppress the immune response, resulting in drug resistance to conventional drugs in prostate cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The main targets of toxicity were casp3, TNF, IL10, IL1B, BAG3, CCNB1, CCNE1, and CDC25A, and the biological pathways implicated were signal transduction involved in DNA damage checkpoints, cellular and chemical responses to oxidative stress, DNA damage response signal transduction by P53, stress-activated protein kinase signaling cascade, netrin-UNC5B signaling, PTEN gene regulation, and immune response.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “RESULTS: Three tumors were tested only by Sanger sequencing and were negative for BRAFV600E, HRAS, KRAS, NRAS, TERT promoter, PTEN, and PIK3CA mutations.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The triple therapy also revealed the best suppression of the PI3K/mTOR/HIF1α pathway by increasing its endogenous inhibitors (PTEN/AMPKα) in all cell lines.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Notch signaling, PTEN/Akt/mTOR axis, KRAS mutation, JAK/STAT signaling, P53, EGFR, and the VEGFs have all been linked to OC, and miRNAs have been shown to have a role in all of these.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Characteristics of PTEN Mutation in Thyroid Tumours: A Retrospective Chart Review.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The most repeated mutations were identified in 3 of 9 examined genes, namely TP53, PIK3CA and PTEN, with highest rates of increase in Group 3.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “PTEN rs701848 Polymorphism is Associated with Trastuzumab Resistance in HER2-positive Metastatic Breast Cancer and Predicts Progression-free Survival.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Canagliflozin alleviates valproic acid-induced autism in rat pups: Role of PTEN/PDK/PPAR-γ signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “No unique factor was correlated with aggressiveness; however, CNA-positive thyroid nodules that were associated with high-risk mutations such as BRAF V600E, TP53, NTRK1/3 fusion, or PTEN mutation with high allele frequency (AF) ended up being aggressive cancers.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Moreover, gene alterations in APC, EGFR, FBXW7, TP53, PTEN, K-ras genes were concomitant in CRC.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “METHODS: We carried out targeted next-generation sequencing of six PI3K pathway genes (PIK3CA, PIK3R1, PTEN, AKT1, TSC2, and mTOR) in a total of 93 South Indian cervical cancer samples and confirmed them by sanger sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The potential mechanism of action of the formulation was determined by measuring the mRNA levels of the tumor-associated genes PTEN, P53, and KRT18 and the protein expression levels with a human oncology protein array.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The key genes, including EGFR, MYC, VEGFA, and PTEN, are targeted by TF such as AR, Sp1, TP53, NF-KB1, STAT3, RELA.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Moreover, the inflammatory progress mRNA and protein markers nuclear factor kappa B (NFκB), phosphatase and tensin homolog (PTEN), proliferating cell nuclear antigen (PCNA), cyclooxygenase-2 (COX-2) and occludin were significantly down-regulated by BEY treatment.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “A number of genes and proteins linked with both disorders have been tabulated, including MECP2, ADNP, SCN2A, NLGN, SHANK, PTEN, RELN, and FMR1.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Giant cell fibroblastoma (GCF) presented as painless swelling in the trunk, positive for CD34 with PTEN gene mutation.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “miR-129 Attenuates Myocardial Ischemia Reperfusion Injury by Regulating the Expression of PTEN in Rats.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Systemic lupus erythematosus in a girl with PTEN variant and transaldolase deficiency: a novel phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “RESULTS: Sequencing analysis identified missense, nonsense and frameshift mutations in TP53 (66%), PIK3CA (27%), CDKN2A (25%), EGFR (18%), and PTEN (14%).” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Other genetic alterations including EML4-NTRK1, EML4-ALK, NRAS, KRAS, PTEN, and CREBBP occurred once each.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Besides the importance of its mutations in cell proliferation, BRAF is associated with lymph node, brain and liver metastasis, along with the loss of PTEN expression and ATG5.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “In HCC827 xenografts treated with the combination, survival of mice was prolonged after therapy discontinuation, tumors that recurred were less aggressive, and two mechanisms of HER inhibitor resistance involving c-Met activation and PTEN loss were blocked.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Cardioprotective Effect of Tangeretin by Inhibiting PTEN/AKT/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The lesion is associated with PTEN gene mutation, and it is considered to be one of the diagnostic criteria of Cowden's syndrome.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Whole exome sequencing (WES) recently identified frequent mutations in the genes of GPCR-mediated PI3K pathway (LPAR4, PIK3CA, and PTEN) in a Chinese population with papillary thyroid cancers (PTCs).” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Association of 32-bp deletion polymorphism and promoter methylation of PTEN and hepatitis C virus induced hepatocellular carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “RESULTS: PTEN mutation frequency was almost identical in all ethnic groups studied (White, Black/African American, Asian, Native Hawaiian or other Pacific Islander, and American Indian or Asian Native).” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “AKR1C3, BRCA1, BRCA2, CHGA, CYP19A1, HOXB13, KLK3, and PTEN contained the highest number of 3'UTR, 5'UTR, CDs, Intergenic, and Intronic variants.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “miRNA-21 inhibition suppresses the human epithelial ovarian cancer by targeting PTEN signal pathway.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “OBJECTIVE: Evaluate the frequency and prognostic effect of RAS, BRAF, PIK3CA, PTEN, and EGFR somatic mutations as well as mismatch repair (MMR) deficiency in Lebanese Middle Eastern patients.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Recently tested CNSTs biomarkers include VEGFR-2, EGFRvIII, IL2, PDGFR, MMPs, BRAF, STAT3, PTEN, TERT, AKT, NF2, and BCL2.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “The anticancer activity of TQ has been primarily shown by altering the expression of signal transducers and activator transcription (STAT3), PTEN and p53 genes.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Prediction of potential targets for the identified miRNAs indicates the overexpression of KRAS, BCL2 and down-regulation of PTEN in PCa tumor tissues.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “This study comprehensively investigated a large series of pediatric DTC for single point mutations in BRAF, HRAS, KRAS, NRAS, PIK3CA, PTEN, and TERT.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Mutations commonly observed in astrocytic tumors (IDH1/2, TP53, ATRX, and PTEN) or ependymoma were not identified.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “RESULTS: Targeted sequencing lead to the identification of frequent mutations in TP53 (65 %), APC (36 %), KRAS (35 %), PIK3CA (19 %), PTEN (13 %), EGFR (11 %), SMAD4 (11 %), and FBXW7 (7 %).” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Concurrently, the expression analysis of the PIK3CA and PTEN genes were performed using real-time PCR.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on chromosome 10) binding protein that is significantly mutated in cutaneous melanoma and pancreatic ductal adenocarcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “At the same time, highly heterogeneous short structural variants were discovered in PTEN, RB1, and BRCA2 in all tumor and CTC samples.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “We elucidate a p110α-independent role of homodimerized p85α in the positive regulation of PTEN stability and activity. p110α-free p85α homodimerizes via two intermolecular interactions (SH3:proline-rich region and BH:BH) to selectively bind unphosphorylated activated PTEN.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “PTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Association of the PTEN IVS4 (rs3830675) gene polymorphism with reduced risk of cancer: evidence from a meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Nonalcoholic fatty liver disease progression in rats is accelerated by splenic regulation of liver PTEN/AKT.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Loss of PTEN expression is associated with aggressive behavior and poor prognosis in Middle Eastern triple-negative breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Clinicopathological significance of PTEN and bcl2 expressions in oral squamous cell carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Therefore, we investigated PI3K/AKT genetic alterations such as PIK3CA amplification, PIK3CA mutation, PTEN protein loss and their relationships with various clinicopathological characteristics in 156 EOCs.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “In the present study, we have evaluated PIK3CA mutational status in a series of 410 Middle Eastern CRC and 13 colon cell lines to study the prevalence of PIK3CA mutations in MSI cases, PTEN expression in CRC and possibility of therapeutic targeting of this set of patients.” | 0.98 | hgnc_dict_v1 |